PDB ID 1BCC     CHAIN B
Protein name UBIQUINOL CYTOCHROME C OXIDOREDUCTASE
Uniprot Accession P23004
The number of similar proteins 38
The number of binding states 3
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1BCC (CHAIN: B)
1 P13272  
2 P31800   P13272  
3 P23004   P31800   P13272   P00129  

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Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   PPHPQDLEIT   KLPNGLVIAS   LENYSPGSTI   GVFIKAGSRY   ENSSNLGTSH   50
51   LLRLASSLTT   KGASSFKITR   GIEAVGGKLS   VESTRENMAY   TVECLRDDVE   100
101   ILMEFLLNVT   TAPEFRPWEV   ADLQPQLKID   KAVAFQNPQT   HVIENLHAAA   150
151   YRNALADSLY   CPDYRIGKVT   SVELHDFVQN   HFTSARMALV   GLGVSHPVLK   200
201   NVAEQLLNIR   GGLGLSGAKA   KYRGGEIREQ   NGDSLVHAAI   VAESAAIGGA   250
251   EANAFSVLQH   VLGANPHVKR   GLNATSSLYQ   AVAKGVHNPF   DVSAFNASYS   300
301   DSGLFGFYTI   SQAAYAGQVI   KAAYNQVKTI   AQGNVSNENV   QAAKNKLKAK   350
351   YLMSVESSEG   FLEEVGSQAL   AAGSYNPPST   VLQQIDAVAD   ADVIKAAKKF   400
401   VSRQKSMAAS   GNLGHTPFVD   EL       450

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
52_LYS GLN 8.3kJPN
chr16:21968816 		-
- 0.0001 -
62_ASN SER 8.3kJPN
chr16:21968847 		rs775768534
- 0.0001 -
70_ARG HIS 8.3kJPN
chr16:21968871 		rs371099781
- 0.0001 -
94_GLY ASP ClinVar
chr16:21969911 		rs2141927529
Pathogenic - Mitochondrial complex III deficiency nuclear type 5 [MONDO:MONDO:0014066,MedGen:C3554608,OMIM:615160]
106_ALA VAL 8.3kJPN
chr16:21973807 		-
- 0.0002 -
120_MET ILE 8.3kJPN
chr16:21974094 		rs898449154
- 0.0001 -
134_ARG SER gnomAD
chr16:21974134 		rs2228473
- 0.00606654 -
134_ARG HIS gnomAD
chr16:21974135 		rs781307417
- 0.000175147 -
144_LEU ILE 8.3kJPN
chr16:21974164 		-
- 0.0001 -
155_PRO LEU 8.3kJPN
chr16:21974198 		rs1158265207
- 0.0001 -
165_ALA VAL 8.3kJPN
chr16:21976750 		rs139348570
- 0.0001 -
169_ARG TRP ClinVar
chr16:21976761 		rs374661051
Pathogenic/Likely pathogenic - Mitochondrial complex III deficiency nuclear type 5|not provided [MONDO:MONDO:0014066,MedGen:C3554608,OMIM:615160|MedGen:C3661900]
169_ARG GLN gnomAD
chr16:21976762 		rs4850
- 0.039302 -
183_ILE PHE 8.3kJPN
chr16:21976803 		-
- 0.0001 -
195_VAL ALA 8.3kJPN
chr16:21979962 		-
- 0.0001 -
208_GLY ALA ClinVar
chr16:21980001 		rs1898386320
Pathogenic - Mitochondrial complex III deficiency nuclear type 5 [MONDO:MONDO:0014066,MedGen:C3554608,OMIM:615160]
210_GLY ASP 8.3kJPN
chr16:21982846 		-
- 0.0001 -
225_ASN SER 8.3kJPN
chr16:21982891 		-
- 0.0003 -
240_ARG HIS gnomAD
chr16:21982936 		rs11863893
- 0.0150379 -
245_ARG GLN 8.3kJPN
chr16:21983253 		rs780855199
- 0.0002 -
259_ALA THR 8.3kJPN
chr16:21983294 		rs1324070596
- 0.0001 -
281_ALA GLY 8.3kJPN
chr16:21983361 		-
- 0.0001 -
305_GLN PRO 8.3kJPN
chr16:21983433 		-
- 0.0001 -
329_GLN ARG gnomAD
chr16:21985278 		rs773330878
- 0.000126147 -
356_ASP ASN 8.3kJPN
chr16:21987548 		-
- 0.0001 -
364_LEU VAL 8.3kJPN
chr16:21991875 		-
- 0.0001 -
368_TYR CYS gnomAD
chr16:21991888 		rs139312246
- 0.000135333 -
368_TYR CYS 8.3kJPN
chr16:21991888 		rs139312246
- 0.0167 -
388_VAL ILE 8.3kJPN
chr16:21991947 		rs1233348558
- 0.0002 -
403_ASP GLU 8.3kJPN
chr16:21991994 		-
- 0.0001 -
405_VAL MET 8.3kJPN
chr16:21991998 		rs748748050
- 0.0012 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.