PDB ID 1ATR     CHAIN A
Protein name HEAT-SHOCK COGNATE 70 KD PROTEIN
Uniprot Accession P19120
The number of similar proteins 72
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1ATR (CHAIN: A)
1 Monomeric state
2 Q27974  
3 Q91YN9  
4 Q99933  
5 Q0WUQ1  
6 Q91YN9   Q91YN9  

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Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   MSKGPAVGID   LGTTYSCVGV   FQHGKVEIIA   NDQGNRTTPS   YVAFTDTERL   50
51   IGDAAKNQVA   MNPTNTVFDA   KRLIGRRFDD   AVVQSDMKHW   PFMVVNDAGR   100
101   PKVQVEYKGE   TKSFYPEEVS   SMVLTKMKEI   AEAYLGKTVT   NAVVTVPAYF   150
151   NDSQRQATKD   AGTIAGLNVL   RIINEPTAAA   IAYGLDKKVG   AERNVLIFDL   200
201   GGGVFDVSIL   TIEDGIFEVK   STAGDTHLGG   EDFDNRMVNH   FIAEFKRKHK   250
251   KDISENKRAV   RRLRTACERA   KRTLSSSTQA   SIEIDSLYEG   IDFYTSITRA   300
301   RFEELNADLF   RGTLDPVEKA   LRDAKLDKSQ   IHDIVLVGGS   TRIPKIQKLL   350
351   QDFFNGKELN   KSINPDEAVA   YGAAVQAAIL   SGDKSE     400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
2_ALA VAL gnomAD
chr14:65007575
rs138216816
- 0.000342662 -
6_ALA PRO gnomAD
chr6:31779728
rs9469057
- 0.00760461 -
6_ALA THR gnomAD
chr6:31779728
rs9469057
- 0.000645336 -
6_ALA THR 8.3kJPN
chr6:31779728
rs9469057
- - -
7_ILE VAL 8.3kJPN
chr14:65007589
-
- 0.0001 -
11_LEU PRO gnomAD
chr1:161494486
rs762080859
- 0.000231462 -
11_LEU VAL 8.3kJPN
chr1:161494485
-
- 0.0003 -
18_VAL MET gnomAD
chr6:31783585
rs202172229
- 0.000519447 -
19_GLY ARG 8.3kJPN
chr14:65007625
-
- 0.0001 -
28_ILE THR 8.3kJPN
chr1:161494537
-
- 0.0001 -
31_ASN SER gnomAD
chr6:31779652
rs201814236
- 0.000210757 -
32_ASP ASN 8.3kJPN
chr6:31779650
rs746628579
- 0.0001 -
35_ASN SER 8.3kJPN
chr1:161494558
rs766366684
- 0.0001 -
36_ARG HIS gnomAD
chr6:31779637
rs373639301
- 0.000330054 -
39_PRO THR gnomAD
chr1:161494569
rs529535145
- 0.000750683 -
39_PRO THR 8.3kJPN
chr1:161494569
rs529535145
- 0.0001 -
42_VAL MET gnomAD
chr6:31779620
rs189710538
- 0.000425485 -
42_VAL MET 8.3kJPN
chr6:31779620
rs189710538
- 0.0018 -
51_ILE THR gnomAD
chr6:31779592
rs141349016
- 0.000938422 -
59_VAL GLU 8.3kJPN
chr14:65007746
-
- 0.0001 -
61_MET VAL gnomAD
chr14:65007751
rs140108798
- 0.000457409 -
63_PRO THR 8.3kJPN
chr1:161494641
rs41297698
- 0.0007 -
67_VAL MET 8.3kJPN
chr1:161494653
rs375370283
- 0.0001 -
72_ARG CYS gnomAD
chr6:31779530
rs145946517
- 0.000314148 -
74_ILE MET 8.3kJPN
chr6:31783755
rs1043620
- - -
75_GLY ALA gnomAD
chr1:161494678
rs150647842
- 0.000181345 -
75_GLY SER 8.3kJPN
chr6:31779521
rs368138379
- 0.0001 -
91_PRO SER 8.3kJPN
chr1:161494725
-
- 0.0001 -
91_PRO LEU 8.3kJPN
chr6:31779472
rs199562102
- 0.0018 -
93_ARG GLY gnomAD
chr1:161494731
rs201325536
- 0.0021557 -
93_ARG GLN 8.3kJPN
chr1:161494732
rs400835
- 0.0006 -
98_GLY GLU 8.3kJPN
chr6:31779451
-
- 0.0001 -
103_VAL LEU gnomAD
chr1:161494761
rs140716677
- 0.000100042 -
106_CYS TYR 8.3kJPN
chr1:161494771
-
- 0.0001 -
108_ARG CYS 8.3kJPN
chr1:161494776
rs368369664
- 0.0001 -
110_GLU ASP gnomAD
chr6:31783863
rs562047
- 0.15785 -
110_GLU ASP gnomAD
chr6:31796057
rs144223778
- 0.0579029 -
110_GLU ASP 8.3kJPN
chr6:31783863
rs562047
- 0.0536 -
110_GLU ASP 8.3kJPN
chr6:31796057
rs144223778
- 0.053 -
111_ASP GLU 8.3kJPN
chr1:161494787
-
- 0.0001 -
111_THR ALA 8.3kJPN
chr11:122931381
-
- 0.0001 -
113_ALA VAL 8.3kJPN
chr6:31783871
-
- 0.0001 -
116_PRO LEU 8.3kJPN
chr6:31779397
rs1339887302
- 0.0001 -
119_ILE VAL 8.3kJPN
chr1:161494809
rs772752500
- 0.0001 -
129_GLU ASP 8.3kJPN
chr6:31779357
-
- 0.0001 -
132_GLU LYS gnomAD
chr6:31796121
rs1406810342
- 0.000110448 -
135_LEU VAL 8.3kJPN
chr1:161494857
-
- 0.0001 -
138_PRO SER gnomAD
chr6:31796139
rs1414774525
- 0.000129938 -
140_THR SER 8.3kJPN
chr11:122930969
rs141156763
- 0.0018 -
146_VAL MET 8.3kJPN
chr1:161494890
rs373442940
- 0.0001 -
146_VAL GLU 8.3kJPN
chr1:161494891
-
- 0.0001 -
151_ASN SER gnomAD
chr1:161494906
rs10919225
- 0.00231426 -
151_ASN SER 8.3kJPN
chr6:31779292
rs775085801
- 0.0001 -
152_ASP ASN gnomAD
chr1:161494908
rs10919226
- 0.00231898 -
155_ARG SER 8.3kJPN
chr6:31779281
rs202165632
- 0.0006 -
157_ALA VAL gnomAD
chr1:161494924
rs41297702
- 0.000115939 -
158_THR ILE gnomAD
chr6:31784006
rs1246559171
- 0.00011217 -
162_GLY CYS 8.3kJPN
chr14:65008054
-
- 0.0001 -
171_ARG TRP 8.3kJPN
chr1:161494965
rs775207128
- 0.0001 -
174_ASN SER 8.3kJPN
chr6:31779223
rs761403757
- 0.0001 -
177_THR MET 8.3kJPN
chr1:161494984
rs376584149
- 0.0001 -
181_ILE VAL 8.3kJPN
chr1:161494995
rs777795960
- 0.0001 -
181_ILE VAL 8.3kJPN
chr11:122930847
-
- 0.0001 -
186_ASP GLY 8.3kJPN
chr1:161495011
-
- 0.0001 -
187_ARG GLN 8.3kJPN
chr1:161495014
rs1057428989
- - -
188_THR ARG gnomAD
chr6:31796290
rs1222040287
- 0.000272377 -
192_GLU LYS gnomAD
chr1:161495028
rs41297714
- 0.000139635 -
192_GLU LYS 8.3kJPN
chr1:161495028
rs41297714
- 0.0054 -
193_ARG GLN gnomAD
chr6:31779166
rs201198988
- 0.000974295 -
193_ARG TER 8.3kJPN
chr6:31779167
rs770917469
- 0.0001 -
195_VAL MET gnomAD
chr1:161495037
rs139552185
- 0.00018727 -
196_LEU PHE gnomAD
chr1:161495040
rs1079109
- 0.118177 -
196_LEU PHE 8.3kJPN
chr1:161495040
rs1079109
- 0.2291 -
199_ASP TYR 8.3kJPN
chr6:31779149
rs373875697
- 0.0001 -
204_THR ILE gnomAD
chr1:161495065
rs149827217
- 0.000258713 -
207_VAL MET 8.3kJPN
chr6:31779125
rs781761072
- 0.0001 -
219_VAL ILE gnomAD
chr6:31779089
rs150472288
- 0.000777469 -
225_ASP ASN gnomAD
chr6:31784206
rs1339464388
- 0.00270479 -
232_ASP ASN gnomAD
chr1:161495148
rs147002100
- 0.000146966 -
238_VAL MET 8.3kJPN
chr14:65008288
-
- 0.0001 -
242_ALA VAL 8.3kJPN
chr14:65008301
rs770917203
- 0.0004 -
256_ASN ILE 8.3kJPN
chr14:65008343
-
- 0.0001 -
261_ARG HIS 8.3kJPN
chr1:161495236
-
- - -
265_THR ALA 8.3kJPN
chr6:31778951
rs769994484
- 0.0017 -
266_ALA THR gnomAD
chr6:31778948
rs34620296
- 0.00490996 -
266_ALA THR 8.3kJPN
chr6:31778948
rs34620296
- 0.002 -
269_ARG GLY gnomAD
chr6:31796532
rs1414260858
- 0.000125597 -
270_ALA THR 8.3kJPN
chr1:161495262
-
- 0.0001 -
270_ALA VAL 8.3kJPN
chr1:161495263
-
- 0.0001 -
272_ARG LEU 8.3kJPN
chr1:161495269
-
- 0.0001 -
273_THR SER 8.3kJPN
chr14:65008393
-
- 0.0001 -
274_LEU PRO 8.3kJPN
chr1:161495275
rs200790521
- 0.1267 -
281_ASN ASP 8.3kJPN
chr6:31778903
rs754506860
- 0.0001 -
282_ILE MET 8.3kJPN
chr14:65008422
-
- 0.0001 -
292_ASP GLY gnomAD
chr6:31778869
rs34360259
- 0.000119414 -
292_ASP GLY 8.3kJPN
chr6:31778869
rs34360259
- 0.0104 -
293_PHE SER gnomAD
chr1:161495332
rs543491153
- 0.000642797 -
294_TYR HIS 8.3kJPN
chr1:161495334
-
- 0.0002 -
295_THR MET gnomAD
chr6:31796611
rs1291288994
- 0.000140647 -
295_THR LYS 8.3kJPN
chr1:161495338
rs41297718
- 0.1629 -
295_THR ILE 8.3kJPN
chr11:122930417
rs763133730
- 0.0001 -
297_ILE PHE 8.3kJPN
chr6:31778855
-
- 0.0001 -
304_GLU LYS gnomAD
chr1:161495364
rs748365478
- 0.000112116 -
306_CYS TYR 8.3kJPN
chr1:161495371
-
- 0.0002 -
308_ASP HIS 8.3kJPN
chr1:161495376
rs529246286
- 0.0044 -
322_ARG GLN gnomAD
chr6:31778779
rs142398035
- 0.000103412 -
332_HIS GLN gnomAD
chr6:31796723
rs1474071038
- 0.000148412 -
334_VAL PHE gnomAD
chr1:161495454
rs417707
- 0.000222932 -
337_VAL MET gnomAD
chr1:161495463
rs142859332
- 0.00284643 -
338_GLY ARG 8.3kJPN
chr1:161495466
-
- 0.0001 -
339_GLY ASP gnomAD
chr1:161495470
rs138329594
- 0.000139366 -
339_GLY SER 8.3kJPN
chr6:31778729
-
- 0.0001 -
348_LYS ARG gnomAD
chr1:161495497
rs144853604
- 0.000580274 -
360_ASN LYS gnomAD
chr6:31784613
rs1313269531
- 0.00052573 -
362_SER ASN 8.3kJPN
chr1:161495539
rs768447503
- 0.0001 -
373_ALA SER 8.3kJPN
chr1:161495571
rs9659608
- 0.2275 -
383_ASP ASN 8.3kJPN
chr1:161495601
rs746948130
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.