PDB ID 1ATR     CHAIN A
Protein name HEAT-SHOCK COGNATE 70 KD PROTEIN
Uniprot Accession P19120
The number of similar proteins 72
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1ATR (CHAIN: A)
1 Monomeric state
2 Q27974  
3 Q91YN9  
4 Q99933  
5 Q0WUQ1  
6 Q91YN9   Q91YN9  

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Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   MSKGPAVGID   LGTTYSCVGV   FQHGKVEIIA   NDQGNRTTPS   YVAFTDTERL   50
51   IGDAAKNQVA   MNPTNTVFDA   KRLIGRRFDD   AVVQSDMKHW   PFMVVNDAGR   100
101   PKVQVEYKGE   TKSFYPEEVS   SMVLTKMKEI   AEAYLGKTVT   NAVVTVPAYF   150
151   NDSQRQATKD   AGTIAGLNVL   RIINEPTAAA   IAYGLDKKVG   AERNVLIFDL   200
201   GGGVFDVSIL   TIEDGIFEVK   STAGDTHLGG   EDFDNRMVNH   FIAEFKRKHK   250
251   KDISENKRAV   RRLRTACERA   KRTLSSSTQA   SIEIDSLYEG   IDFYTSITRA   300
301   RFEELNADLF   RGTLDPVEKA   LRDAKLDKSQ   IHDIVLVGGS   TRIPKIQKLL   350
351   QDFFNGKELN   KSINPDEAVA   YGAAVQAAIL   SGDKSE     400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
11_LEU VAL 4.7kJPN
chr1:161494485
-
- 0.0003 -
16_SER CYS 4.7kJPN
chr6:31779697
rs1007813910
- 0.0001 -
16_SER THR 4.7kJPN
chr6:31779698
-
- 0.0001 -
19_GLY ARG 4.7kJPN
chr14:65007625
-
- 0.0001 -
28_ILE THR 4.7kJPN
chr1:161494537
-
- 0.0001 -
30_ALA THR 4.7kJPN
chr14:65007658
-
- 0.0001 -
32_ASP ASN 4.7kJPN
chr6:31779650
rs746628579
- 0.0001 -
39_PRO THR 4.7kJPN
chr1:161494569
rs529535145
- 0.0001 -
42_VAL MET 4.7kJPN
chr6:31779620
rs189710538
- 0.0016 -
45_THR LYS 4.7kJPN
chr14:65007704
-
- 0.0001 -
49_ARG SER 4.7kJPN
chr14:65007715
-
- 0.0001 -
59_VAL GLU 4.7kJPN
chr14:65007746
-
- 0.0001 -
63_PRO THR 4.7kJPN
chr1:161494641
rs41297698
- 0.0006 -
67_VAL MET 4.7kJPN
chr1:161494653
rs375370283
- 0.0001 -
75_GLY SER 4.7kJPN
chr6:31779521
rs368138379
- 0.0001 -
91_PRO LEU 4.7kJPN
chr6:31779472
rs199562102
- 0.0014 -
93_ARG GLN 4.7kJPN
chr1:161494732
rs400835
- 0.0009 -
106_CYS TYR 4.7kJPN
chr1:161494771
-
- 0.0002 -
110_GLU ASP 4.7kJPN
chr6:31783863
rs562047
- 0.0572 -
110_GLU ASP 4.7kJPN
chr6:31796057
rs144223778
- 0.0562 -
111_ASP GLU 4.7kJPN
chr1:161494787
-
- 0.0001 -
116_PRO LEU 4.7kJPN
chr6:31779397
rs1339887302
- 0.0001 -
119_ILE VAL 4.7kJPN
chr1:161494809
rs772752500
- 0.0002 -
129_GLU ASP 4.7kJPN
chr6:31779357
-
- 0.0001 -
140_THR SER 4.7kJPN
chr11:122930969
rs141156763
- 0.0019 -
146_VAL MET 4.7kJPN
chr1:161494890
rs373442940
- 0.0001 -
155_ARG SER 4.7kJPN
chr6:31779281
rs202165632
- 0.0003 -
162_GLY CYS 4.7kJPN
chr14:65008054
-
- 0.0001 -
171_ARG TRP 4.7kJPN
chr1:161494965
rs775207128
- 0.0001 -
174_ASN SER 4.7kJPN
chr6:31779223
rs761403757
- 0.0001 -
177_THR MET 4.7kJPN
chr1:161494984
rs376584149
- 0.0001 -
181_ILE VAL 4.7kJPN
chr1:161494995
rs777795960
- 0.0001 -
181_ILE VAL 4.7kJPN
chr11:122930847
-
- 0.0001 -
186_ASP GLY 4.7kJPN
chr1:161495011
-
- 0.0001 -
192_GLU LYS 4.7kJPN
chr1:161495028
rs41297714
- 0.0085 -
193_ARG TER 4.7kJPN
chr6:31779167
rs770917469
- 0.0002 -
196_LEU PHE 4.7kJPN
chr1:161495040
rs1079109
- 0.2263 -
199_ASP TYR 4.7kJPN
chr6:31779149
rs373875697
- 0.0001 -
207_VAL MET 4.7kJPN
chr6:31779125
rs781761072
- 0.0001 -
210_LEU PHE 4.7kJPN
chr11:122930673
-
- 0.0001 -
242_ALA VAL 4.7kJPN
chr14:65008301
rs770917203
- 0.0004 -
249_HIS TYR 4.7kJPN
chr11:122930556
-
- 0.0001 -
255_GLU ASP 4.7kJPN
chr11:122930536
-
- 0.0001 -
261_ARG SER 4.7kJPN
chr11:122930518
-
- 0.0001 -
265_THR ALA 4.7kJPN
chr6:31778951
rs769994484
- 0.0019 -
266_ALA THR 4.7kJPN
chr6:31778948
rs34620296
- 0.0021 -
269_ARG SER 4.7kJPN
chr11:122930496
-
- 0.0001 -
270_ALA VAL 4.7kJPN
chr1:161495263
-
- 0.0002 -
272_ARG LEU 4.7kJPN
chr1:161495269
-
- 0.0001 -
274_LEU PRO 4.7kJPN
chr1:161495275
rs200790521
- 0.0807 -
281_ASN ASP 4.7kJPN
chr6:31778903
rs754506860
- 0.0001 -
282_ILE MET 4.7kJPN
chr14:65008422
-
- 0.0001 -
292_ASP GLY 4.7kJPN
chr6:31778869
rs34360259
- 0.0103 -
294_TYR HIS 4.7kJPN
chr1:161495334
-
- 0.0001 -
295_THR LYS 4.7kJPN
chr1:161495338
rs41297718
- 0.137 -
297_ILE PHE 4.7kJPN
chr6:31778855
-
- 0.0001 -
306_CYS TYR 4.7kJPN
chr1:161495371
-
- 0.0002 -
308_ASP HIS 4.7kJPN
chr1:161495376
rs529246286
- 0.0051 -
338_GLY ARG 4.7kJPN
chr1:161495466
-
- 0.0001 -
346_VAL MET 4.7kJPN
chr6:31778708
-
- 0.0001 -
348_ARG GLN 4.7kJPN
chr6:31778701
rs923849656
- 0.0001 -
353_TYR TER 4.7kJPN
chr6:31778685
-
- 0.0001 -
353_TYR PHE 4.7kJPN
chr6:31778686
-
- 0.0001 -
353_PHE TYR 4.7kJPN
chr11:122930243
rs747492962
- 0.0001 -
357_ARG SER 4.7kJPN
chr6:31778675
-
- 0.0001 -
358_ASP GLU 4.7kJPN
chr6:31778670
-
- 0.0001 -
373_ALA SER 4.7kJPN
chr1:161495571
rs9659608
- 0.2122 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.