PDB ID 1AQ1     CHAIN A
Protein name CYCLIN-DEPENDENT PROTEIN KINASE 2
Uniprot Accession P24941
The number of similar proteins 395
The number of binding states 10
The number of binding partners 9

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1AQ1 (CHAIN: A)
1 Monomeric state
2 P61024  
3 P89883  
4 P20248  
5 Q5MJ70  
6 Q16667  
7 P46527   Q5MJ70  
8 P20248   P46527  
9 P20248   Q99741  
10 P24941   P20248   P20248  

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Format:

Molecule viewer

#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MENFQKVEKI   GEGTYGVVYK   ARNKLTGEVV   ALKKIRLDTE   TEGVPSTAIR   50
51   EISLLKELNH   PNIVKLLDVI   HTENKLYLVF   EFLHQDLKKF   MDASALTGIP   100
101   LPLIKSYLFQ   LLQGLAFCHS   HRVLHRDLKP   QNLLINTEGA   IKLADFGLAR   150
151   AFGVPVRTYT   HEVVTLWYRA   PEILLGCKYY   STAVDIWSLG   CIFAEMVTRR   200
201   ALFPGDSEID   QLFRIFRTLG   TPDEVVWPGV   TSMPDYKPSF   PKWARQDFSK   250
251   VVPPLDEDGR   SLLSQMLHYD   PNKRISAKAA   LAHPFFQDVT   KPVPHLRL   300

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
15_TYR SER VAR_016157 rs3087335
Polymorphism - -
18_VAL LEU VAR_053927 rs11554376
Polymorphism - -
45_PRO LEU VAR_041972 -
Unclassified - A glioblastoma multiforme sample
77_TYR HIS 4.7kJPN
chr12:56361867
rs1325392225
- 0.0001 -
109_PHE LEU 4.7kJPN
chr12:56362573
rs756703184
- 0.0004 -
200_ARG GLN 4.7kJPN
chr12:56364838
rs763512696
- 0.0002 -
214_ARG GLN 4.7kJPN
chr12:56364880
-
- 0.0001 -
231_THR ASN 4.7kJPN
chr12:56364931
-
- 0.0001 -
245_ARG TRP 4.7kJPN
chr12:56364972
rs868674487
- 0.0002 -
245_ARG GLN 4.7kJPN
chr12:56364973
rs144092294
- 0.0016 -
255_LEU VAL 4.7kJPN
chr12:56365002
rs1359177454
- 0.0003 -
256_ASP ASN 4.7kJPN
chr12:56365005
-
- 0.0001 -
270_ASP ASN 4.7kJPN
chr12:56365320
rs759820038
- 0.0001 -
290_THR SER VAR_019988 rs2069413
Polymorphism - -
290_THR SER 4.7kJPN
chr12:56365381
rs2069413
- 0.0065 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.