PDB ID 1APM     CHAIN E
Protein name cAMP-DEPENDENT PROTEIN KINASE
Uniprot Accession P05132
The number of similar proteins 281
The number of binding states 7
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1APM (CHAIN: E)
1 Monomeric state
2 P12367  
3 P12369  
4 P05132  
5 P42588  
6 P31324   P31324  
7 P00517   P00517   P00517  

Downdload

Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   GNAAAAKKGX   EQESVKEFLA   KAKEDFLKKW   ETPSQNTAQL   DQFDRIKTLG   50
51   TGSFGRVMLV   KHKESGNHYA   MKILDKQKVV   KLKQIEHTLN   EKRILQAVNF   100
101   PFLVKLEFSF   KDNSNLYMVM   EYVAGGEMFS   HLRRIGRFAE   PHARFYAAQI   150
151   VLTFEYLHSL   DLIYRDLKPE   NLLIDQQGYI   QVTDFGFAKR   VKGRTWXLCG   200
201   TPEYLAPEII   LSKGYNKAVD   WWALGVLIYE   MAAGYPPFFA   DQPIQIYEKI   250
251   VSGKVRFPSH   FSSDLKDLLR   NLLQVDLTKR   FGNLKNGVND   IKNHKWFATT   300
301   DWIAIYQRKV   EAPFIPKFKG   PGDTSNFDDY   EEEEIRVXIN   EKCGKEFTEF   350

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
10_GLU LYS 4.7kJPN
chr9:71628978
rs1286264874
- 0.0006 -
41_ASP ASN 4.7kJPN
chr9:71628885
-
- 0.0001 -
43_PHE LEU 4.7kJPN
chr9:71628877
-
- 0.0001 -
45_ARG GLN 4.7kJPN
chr19:14217672
rs56085217
- 0.0001 -
52_GLY ALA 4.7kJPN
chr9:71628851
rs200902927
- 0.0001 -
62_HIS ARG 4.7kJPN
chr1:84647962
-
- 0.0001 -
65_THR ILE 4.7kJPN
chr9:71628812
rs1355972241
- 0.0002 -
67_GLN HIS 4.7kJPN
chr1:84647978
rs745646679
- 0.0005 -
73_ILE MET ClinVar
chr9:71628787
rs724159972
Pathogenic - Platelet-type bleeding disorder 19 [MedGen:C4015405,OMIM:616176,Orphanet:ORPHA438207]
90_ASN LYS 4.7kJPN
chr9:71628736
rs758425612
- 0.0001 -
93_ARG GLY 4.7kJPN
chr9:71628729
-
- 0.0001 -
136_GLY ARG 4.7kJPN
chr9:71628600
rs571783065
- 0.0001 -
147_ALA THR 4.7kJPN
chr19:14208680
rs1192231636
- 0.0001 -
165_ARG CYS 4.7kJPN
chr9:71628513
-
- 0.0001 -
173_LEU PHE 4.7kJPN
chr1:84662401
-
- 0.0001 -
196_TRP ARG 4.7kJPN
chr1:84663454
rs772092967
- 0.0001 -
205_LEU ARG ClinVar
chr19:14208416
rs386352352
Pathogenic/Likely pathogenic - Pigmented nodular adrenocortical disease, primary, 4 [MedGen:C4014425,OMIM:615830]; not provided [MedGen:CN517202]
223_ALA ASP 4.7kJPN
chr9:71628338
rs778655344
- 0.0002 -
246_ILE SER 4.7kJPN
chr9:71628269
-
- 0.0001 -
265_LEU PHE 4.7kJPN
chr9:71628213
rs202063130
- 0.0014 -
267_HIS ASP 4.7kJPN
chr9:71628207
rs3730386
- 0.2382 -
274_GLN TER 4.7kJPN
chr9:71628186
-
- 0.0001 -
281_PHE TYR 4.7kJPN
chr19:14204525
-
- 0.0001 -
293_ASN SER 4.7kJPN
chr19:14204489
-
- 0.0003 -
293_ASN ASP 4.7kJPN
chr19:14204490
-
- 0.0001 -
319_THR SER 4.7kJPN
chr9:71628051
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.