PDB ID 1AOI     CHAIN D
Protein name HISTONE H2B
Uniprot Accession P02281
The number of similar proteins 79
The number of binding states 16
The number of binding partners 17

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   KKRRKTRKES   YAIYVYKVLK   QVHPDTGISS   KAMSIMNSFV   NDVFERIAGE   50
51   ASRLAHYNKR   STITSREIQT   AVRLLLPGEL   AKHAVSEGTK   AVTKYTSAK   100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
24_LYS ARG 8.3kJPN
chr1:149858108 		-
- 0.0001 -
25_LYS ARG 8.3kJPN
chr6:27114492 		-
- 0.0001 -
26_ARG CYS 8.3kJPN
chr6:27100442 		rs1239817177
- 0.0001 -
26_ARG HIS 8.3kJPN
chr6:27861329 		-
- 0.0005 -
28_ARG CYS 8.3kJPN
chr6:26199880 		rs764523762
- 0.0001 -
28_ARG CYS 8.3kJPN
chr6:27100436 		rs769130601
- 0.0001 -
29_THR ILE 8.3kJPN
chr6:25727237 		rs147766950
- 0.0001 -
29_SER ARG 8.3kJPN
chr6:26184120 		-
- 0.0001 -
31_LYS ARG gnomAD
chr1:149783775 		rs143086420
- 0.00139572 -
32_GLU TER 8.3kJPN
chr6:25727245 		-
- 0.0001 -
34_TYR TER 8.3kJPN
chr6:26251992 		-
- 0.0001 -
34_TYR CYS 8.3kJPN
chr6:27100417 		rs1305868682
- 0.0001 -
35_SER CYS gnomAD
chr6:25727255 		rs199691595
- 0.000107405 -
35_SER CYS 8.3kJPN
chr6:26216756 		-
- 0.0001 -
35_SER CYS 8.3kJPN
chr6:26251994 		-
- 0.0003 -
36_VAL ALA 8.3kJPN
chr1:149783760 		-
- 0.0001 -
36_VAL LEU 8.3kJPN
chr6:27775567 		rs780283212
- 0.0001 -
38_VAL LEU 8.3kJPN
chr1:149783755 		rs782143987
- 0.0001 -
40_LYS GLU 8.3kJPN
chr1:228645960 		rs1192514228
- 0.0001 -
41_VAL LEU 8.3kJPN
chr6:26252011 		rs774570728
- 0.0003 -
47_PRO LEU 8.3kJPN
chr6:25727291 		rs143128181
- 0.0001 -
47_PRO SER 8.3kJPN
chr6:26199937 		rs1023705388
- 0.0001 -
47_PRO THR 8.3kJPN
chr6:27100379 		rs774667736
- 0.0002 -
48_ASP ASN 8.3kJPN
chr6:26252032 		-
- 0.0001 -
48_ASP GLY 8.3kJPN
chr6:27782976 		-
- 0.0001 -
49_THR SER 8.3kJPN
chr6:26199944 		-
- 0.0001 -
49_THR ALA 8.3kJPN
chr6:26273360 		rs1458054891
- 0.0001 -
50_GLY ALA 8.3kJPN
chr6:26043725 		-
- 0.0001 -
50_GLY SER 8.3kJPN
chr6:26199946 		-
- 0.0001 -
50_GLY SER 8.3kJPN
chr6:27775525 		-
- 0.0001 -
51_ILE VAL 8.3kJPN
chr6:26216709 		-
- 0.0001 -
52_SER LEU 8.3kJPN
chr1:228645997 		rs1353478558
- 0.0001 -
52_SER PHE 8.3kJPN
chr6:26252045 		rs750512885
- 0.0001 -
53_SER PHE 8.3kJPN
chr6:26043716 		-
- 0.0001 -
53_SER PHE 8.3kJPN
chr6:26252048 		rs1391696815
- 0.0001 -
54_LYS MET 8.3kJPN
chr1:149783706 		-
- 0.0001 -
55_ALA VAL 8.3kJPN
chr6:26043710 		-
- 0.0001 -
56_MET ILE 8.3kJPN
chr1:228646010 		rs1440295879
- 0.0001 -
56_MET LEU 8.3kJPN
chr6:26252056 		-
- 0.0001 -
57_GLY SER 8.3kJPN
chr6:27861421 		rs1410298024
- 0.0001 -
59_MET ILE 8.3kJPN
chr6:27100341 		rs1402019530
- 0.0001 -
60_ASN SER 8.3kJPN
chr6:25727330 		rs1237711095
- 0.0001 -
63_VAL ILE gnomAD
chr6:26043687 		rs566958517
- 0.000147129 -
63_VAL ILE 8.3kJPN
chr1:149783680 		rs1438376476
- 0.0001 -
64_ASN SER 8.3kJPN
chr1:228646033 		-
- 0.0001 -
66_ILE THR gnomAD
chr6:25727348 		rs761537792
- 0.000186952 -
66_ILE VAL gnomAD
chr6:26043678 		rs144272993
- 0.000111342 -
66_ILE VAL 8.3kJPN
chr1:228646038 		rs779849447
- 0.0001 -
66_ILE VAL 8.3kJPN
chr6:25727347 		rs774096146
- 0.0001 -
67_PHE SER 8.3kJPN
chr6:25727351 		rs1431133085
- 0.0001 -
69_ARG CYS 8.3kJPN
chr6:26273420 		rs757772183
- 0.0001 -
69_ARG CYS 8.3kJPN
chr6:27861457 		-
- 0.0001 -
70_ILE LEU 8.3kJPN
chr6:25727359 		-
- 0.0001 -
71_ALA PRO 8.3kJPN
chr6:27775462 		-
- 0.0001 -
72_SER ASN gnomAD
chr6:25727366 		rs753295081
- 0.000107417 -
72_SER ASN 8.3kJPN
chr6:25727366 		rs753295081
- 0.0002 -
72_GLY ASP 8.3kJPN
chr6:26273430 		-
- 0.0001 -
74_ALA VAL gnomAD
chr6:26252111 		rs199520662
- 0.000139168 -
74_ALA SER 8.3kJPN
chr1:149857959 		-
- 0.0003 -
74_ALA VAL 8.3kJPN
chr1:228646063 		rs759631368
- 0.0002 -
75_SER PRO 8.3kJPN
chr1:228646065 		-
- 0.0001 -
76_ARG LEU 8.3kJPN
chr1:228646069 		rs1244127669
- 0.0001 -
76_ARG HIS 8.3kJPN
chr6:26158636 		-
- 0.0001 -
78_ALA SER gnomAD
chr6:25727383 		rs150616838
- 0.000143293 -
78_ALA GLU 8.3kJPN
chr6:26123888 		rs752759673
- 0.0001 -
78_ALA THR 8.3kJPN
chr6:26216628 		-
- 0.0001 -
78_ALA THR 8.3kJPN
chr6:26252122 		rs745564288
- 0.0019 -
79_HIS GLN 8.3kJPN
chr6:26216623 		-
- 0.0001 -
79_HIS TYR 8.3kJPN
chr6:26252125 		rs755796999
- 0.0001 -
81_ASN SER 8.3kJPN
chr6:26252132 		rs542798893
- 0.0003 -
82_LYS ARG gnomAD
chr6:26200043 		rs151100683
- 0.000421481 -
84_SER TER 8.3kJPN
chr6:26184286 		rs191131837
- 0.0033 -
86_ILE THR gnomAD
chr6:27861509 		rs148188690
- 0.000206855 -
86_ILE VAL 8.3kJPN
chr6:27861508 		-
- 0.0001 -
89_ARG LYS gnomAD
chr6:27100252 		rs116395770
- 0.000170985 -
89_ARG GLY 8.3kJPN
chr6:26184300 		-
- 0.0001 -
89_ARG LYS 8.3kJPN
chr6:26273481 		-
- 0.0001 -
90_GLU TER 8.3kJPN
chr6:26158677 		-
- 0.0001 -
91_ILE VAL gnomAD
chr1:149857908 		rs373633210
- 0.000231162 -
91_ILE PHE 8.3kJPN
chr6:27806722 		-
- 0.0001 -
92_GLN TER 8.3kJPN
chr6:26043600 		-
- 0.0001 -
92_GLN LEU 8.3kJPN
chr6:26158684 		-
- 0.0001 -
92_GLN LEU 8.3kJPN
chr6:26184310 		rs768613673
- 0.0001 -
94_ALA THR 8.3kJPN
chr6:26043594 		-
- 0.0001 -
98_LEU MET 8.3kJPN
chr6:26043582 		-
- 0.0001 -
98_LEU VAL 8.3kJPN
chr6:26158701 		-
- 0.0001 -
104_ALA SER 8.3kJPN
chr6:27114256 		-
- 0.0001 -
104_ALA THR 8.3kJPN
chr6:27775363 		-
- 0.0001 -
107_ALA THR 8.3kJPN
chr6:27775354 		-
- 0.0001 -
116_THR SER 8.3kJPN
chr6:26200144 		-
- 0.0001 -
117_LYS ARG 8.3kJPN
chr6:26252240 		rs752163332
- 0.0001 -
119_THR SER 8.3kJPN
chr6:26043518 		rs1266161609
- 0.0001 -
120_SER ASN 8.3kJPN
chr6:26043515 		rs769308092
- 0.0001 -
121_SER PHE 8.3kJPN
chr6:25727513 		rs201800096
- 0.0004 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.