PDB ID 1AO6     CHAIN A
Protein name SERUM ALBUMIN
Uniprot Accession P02768
The number of similar proteins 106
The number of binding states 8
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1AO6 (CHAIN: A)
1 Monomeric state
2 P02768  
3 4HGK  
4 5VNW  
5 2VDB  
6 P61769   P55899  
7 5FUO   5FUO  
8 P02768   P02768  

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Molecule viewer

#binding
partners
  2
  1
  0

Sequence information

1   DAHKSEVAHR   FKDLGEENFK   ALVLIAFAQY   LQQCPFEDHV   KLVNEVTEFA   50
51   KTCVADESAE   NCDKSLHTLF   GDKLCTVATL   RETYGEMADC   CAKQEPERNE   100
101   CFLQHKDDNP   NLPRLVRPEV   DVMCTAFHDN   EETFLKKYLY   EIARRHPYFY   150
151   APELLFFAKR   YKAAFTECCQ   AADKAACLLP   KLDELRDEGK   ASSAKQRLKC   200
201   ASLQKFGERA   FKAWAVARLS   QRFPKAEFAE   VSKLVTDLTK   VHTECCHGDL   250
251   LECADDRADL   AKYICENQDS   ISSKLKECCE   KPLLEKSHCI   AEVENDEMPA   300
301   DLPSLAADFV   ESKDVCKNYA   EAKDVFLGMF   LYEYARRHPD   YSVVLLLRLA   350
351   KTYETTLEKC   CAAADPHECY   AKVFDEFKPL   VEEPQNLIKQ   NCELFEQLGE   400
401   YKFQNALLVR   YTKKVPQVST   PTLVEVSRNL   GKVGSKCCKH   PEAKRMPCAE   450
451   DYLSVVLNQL   CVLHEKTPVS   DRVTKCCTES   LVNRRPCFSA   LEVDETYVPK   500
501   EFNAETFTFH   ADICTLSEKE   RQIKKQTALV   ELVKHKPKAT   KEQLKAVMDD   550
551   FAAFVEKCCK   ADDKETCFAE   EGKKLVAASQ   AALGL     600

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(4.7kJPN)		 Disease name
49_PHE TYR VAR_010657 -
Polymorphism - -
60_GLU LYS VAR_000507 rs77050410
Polymorphism - -
63_ASP ASN VAR_000508 rs78574148
Polymorphism - -
66_LEU PRO VAR_013011 rs77892378
Disease - Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
82_GLU LYS VAR_000509 rs80296402
Polymorphism - -
97_GLU GLY VAR_014290 -
Polymorphism - -
97_GLU GLY 4.7kJPN
chr4:74274402 		-
- 0.0001 -
114_ARG GLY VAR_000510 rs77238412
Polymorphism - -
114_ARG TER ClinVar
chr4:74274452 		rs77238412
Pathogenic - Analbuminemia [MedGen:C0878666,OMIM:616000,Orphanet:ORPHA86816]
119_GLU LYS VAR_000511 rs75522063
Polymorphism - -
122_VAL GLU VAR_013012 rs77752336
Polymorphism - -
128_HIS ARG VAR_000512 rs80095457
Polymorphism - -
171_ALA PRO 4.7kJPN
chr4:74275172 		-
- 0.0001 -
177_CYS PHE VAR_000513 rs77656691
Polymorphism - -
191_ALA THR VAR_014291 rs3210154
Polymorphism - -
191_ALA VAL VAR_014292 rs3204504
Polymorphism - -
196_GLN LEU VAR_014293 rs3210163
Polymorphism - -
202_SER ARG 4.7kJPN
chr4:74276089 		rs763471006
- 0.0001 -
215_ALA SER 4.7kJPN
chr4:74277714 		rs1339083689
- 0.0001 -
218_ARG HIS VAR_000514 rs75002628
Disease - Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
218_ARG PRO VAR_013013 rs75002628
Disease - Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
225_LYS GLN VAR_000515 rs79804069
Polymorphism - -
240_LYS GLU VAR_000516 rs79377490
Polymorphism - -
267_ASN LYS 4.7kJPN
chr4:74279166 		-
- 0.0002 -
268_GLN ARG VAR_000517 rs80002911
Polymorphism - -
269_ASP GLY VAR_000518 rs79744198
Polymorphism - -
276_LYS ASN VAR_000519 rs74718349
Polymorphism - -
282_PRO LEU 4.7kJPN
chr4:74279210 		rs755199533
- 0.0001 -
296_ASP GLU 4.7kJPN
chr4:74279253 		-
- 0.0004 -
313_LYS ASN VAR_000520 rs72552710
Polymorphism - -
314_ASP GLY VAR_013014 rs76242087
Polymorphism - -
314_ASP VAL VAR_013015 rs76242087
Polymorphism - -
318_ASN LYS VAR_000521 rs77544362
Polymorphism - -
320_ALA THR VAR_000522 rs78953271
Polymorphism - -
321_GLU LYS VAR_000523 rs72552711
Polymorphism - -
333_GLU LYS VAR_000524 rs77354753
Polymorphism - -
334_TYR CYS 4.7kJPN
chr4:74280766 		rs537985931
- 0.0001 -
354_GLU LYS VAR_000525 rs76593094
Polymorphism - -
354_GLU LYS 4.7kJPN
chr4:74280825 		rs76593094
- 0.0001 -
355_THR ASN 4.7kJPN
chr4:74280829 		-
- 0.0001 -
358_GLU LYS VAR_000526 rs75791663
Polymorphism - -
359_LYS ASN VAR_013016 rs75069738
Polymorphism - -
359_LYS ARG 4.7kJPN
chr4:74280841 		rs1220544264
- 0.0001 -
363_ALA THR 4.7kJPN
chr4:74280852 		rs149483745
- 0.0001 -
365_ASP HIS VAR_000527 rs77187142
Polymorphism - -
365_ASP VAL VAR_000528 rs78538497
Polymorphism - -
372_LYS GLU VAR_000529 rs78166690
Polymorphism - -
375_ASP ASN VAR_000530 rs77514449
Polymorphism - -
375_ASP ASN 4.7kJPN
chr4:74281976 		rs77514449
- 0.0002 -
376_GLU LYS VAR_000531 rs79047363
Polymorphism - -
376_GLU GLN VAR_000532 rs79047363
Polymorphism - -
382_GLU LYS VAR_000533 rs76483862
Polymorphism - -
384_PRO LEU 4.7kJPN
chr4:74282004 		-
- 0.0001 -
389_LYS GLN 4.7kJPN
chr4:74282018 		-
- 0.0001 -
396_GLU LYS VAR_014294 -
Polymorphism - -
406_ALA VAL 4.7kJPN
chr4:74282070 		rs370819889
- 0.0001 -
410_ARG CYS VAR_013017 rs78575701
Polymorphism - -
431_GLY ALA 4.7kJPN
chr4:74283322 		rs767335300
- 0.0001 -
466_LYS GLU VAR_014295 rs1063469
Polymorphism - -
479_GLU LYS VAR_000534 rs80259813
Polymorphism - -
494_ASP ASN VAR_000535 rs75920790
Polymorphism - -
501_GLU LYS VAR_000536 rs75523493
Polymorphism - -
505_GLU LYS VAR_000537 rs74826639
Polymorphism - -
527_THR ILE 4.7kJPN
chr4:74284028 		rs149079814
- 0.0006 -
533_VAL MET VAR_013018 rs78284052
Polymorphism - -
536_LYS GLU VAR_000538 rs77645174
Polymorphism - -
541_LYS GLU VAR_000539 rs80345158
Polymorphism - -
550_ASP GLY VAR_000540 rs79738788
Polymorphism - -
550_ASP ALA VAR_000541 rs79738788
Polymorphism - -
560_LYS GLU VAR_013019 rs76671808
Polymorphism - -
563_ASP ASN VAR_000542 rs76587671
Polymorphism - -
565_GLU LYS VAR_000543 rs75709682
Polymorphism - -
570_GLU LYS VAR_000544 rs79228041
Polymorphism - -
570_GLU LYS ClinVar
chr4:74285351 		rs79228041
Pathogenic - ALBUMIN B [na]
573_LYS GLU VAR_000545 rs80106970
Polymorphism - -
574_LYS ASN VAR_000546 rs75738598
Polymorphism - -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.