PiSITE

PDB ID	1AO6	CHAIN	A
Protein name	SERUM ALBUMIN
Uniprot Accession	P02768
The number of similar proteins	152
The number of binding states	8
The number of binding partners	7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1AO6 (CHAIN: A)
1	Monomeric state
2	P02768
3	4HGK
4	5VNW
5	6ZL1
6	P61769 P55899
7	5FUO 5FUO
8	P02768 P02768

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Only interaction residues

#binding
partners

	3
	2
	1
	0

Sequence information

DAHKSEVAHR

FKDLGEENFK

ALVLIAFAQY

LQQCPFEDHV

KLVNEVTEFA

KTCVADESAE

NCDKSLHTLF

GDKLCTVATL

RETYGEMADC

CAKQEPERNE

100

101

CFLQHKDDNP

NLPRLVRPEV

DVMCTAFHDN

EETFLKKYLY

EIARRHPYFY

150

151

APELLFFAKR

YKAAFTECCQ

AADKAACLLP

KLDELRDEGK

ASSAKQRLKC

200

201

ASLQKFGERA

FKAWAVARLS

QRFPKAEFAE

VSKLVTDLTK

VHTECCHGDL

250

251

LECADDRADL

AKYICENQDS

ISSKLKECCE

KPLLEKSHCI

AEVENDEMPA

300

301

DLPSLAADFV

ESKDVCKNYA

EAKDVFLGMF

LYEYARRHPD

YSVVLLLRLA

350

351

KTYETTLEKC

CAAADPHECY

AKVFDEFKPL

VEEPQNLIKQ

NCELFEQLGE

400

401

YKFQNALLVR

YTKKVPQVST

PTLVEVSRNL

GKVGSKCCKH

PEAKRMPCAE

450

451

DYLSVVLNQL

CVLHEKTPVS

DRVTKCCTES

LVNRRPCFSA

LEVDETYVPK

500

501

EFNAETFTFH

ADICTLSEKE

RQIKKQTALV

ELVKHKPKAT

KEQLKAVMDD

550

551

FAAFVEKCCK

ADDKETCFAE

EGKKLVAASQ

AALGL

600

Variants

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
32_GLN	TER	ClinVar chr4:74272374 rs75470261	Pathogenic	-	-	Analbuminemia [MedGen:C0878666,OMIM:616000,Orphanet:86816]
49_PHE	TYR	VAR_010657 -	LB/B	-	0.3031	-
59_ALA	VAL	gnomAD chr4:74272456 rs200736287	-	0.000378338	0.2452	-
60_GLU	LYS	VAR_000507 rs77050410	LB/B	-	0.1068	-
63_ASP	ASN	VAR_000508 rs78574148	LB/B	-	0.1088	-
66_LEU	PRO	VAR_013011 rs77892378	LP/P	-	0.692	Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
66_LEU	PRO	ClinVar chr4:74272477 rs77892378	Pathogenic	-	0.692	Hyperthyroxinemia, familial dysalbuminemic [MONDO:MONDO:0014448,MedGen:C0342185,OMIM:615999]
82_GLU	LYS	VAR_000509 rs80296402	LB/B	-	0.202	-
84_TYR	CYS	gnomAD chr4:74274363 rs142714816	-	0.000517236	0.7656	-
97_GLU	GLY	VAR_014290 -	LB/B	-	0.1606	-
97_GLU	GLY	8.3kJPN chr4:74274402 -	-	0.0001	0.1606	-
111_ASN	LYS	8.3kJPN chr4:74274445 -	-	0.0001	0.1471	-
114_ARG	GLY	VAR_000510 rs77238412	LB/B	-	0.1149	-
114_ARG	TER	ClinVar chr4:74274452 rs77238412	Pathogenic	-	-	Analbuminemia\|not provided [MedGen:C0878666,OMIM:616000,Orphanet:86816\|MedGen:C3661900]
119_GLU	LYS	VAR_000511 rs75522063	LB/B	-	0.1999	-
122_VAL	GLU	VAR_013012 rs77752336	LB/B	-	0.132	-
128_HIS	ARG	VAR_000512 rs80095457	LB/B	-	0.0575	-
134_PHE	LEU	8.3kJPN chr4:74274514 -	-	0.0001	0.8494	-
153_GLU	ASP	gnomAD chr4:74275120 rs149432908	-	0.000441805	0.6967	-
171_ALA	PRO	8.3kJPN chr4:74275172 -	-	0.0001	0.6439	-
177_CYS	PHE	VAR_000513 rs77656691	LB/B	-	0.9228	-
191_ALA	THR	VAR_014291 rs3210154	LB/B	-	0.082	-
191_ALA	VAL	VAR_014292 rs3204504	LB/B	-	0.0931	-
196_GLN	LEU	VAR_014293 rs3210163	LB/B	-	0.6372	-
202_SER	ARG	8.3kJPN chr4:74276089 rs763471006	-	0.0001	0.9539	-
214_TRP	TER	ClinVar chr4:74277713 rs76454301	Pathogenic	-	-	Analbuminemia [MedGen:C0878666,OMIM:616000,Orphanet:86816]
215_ALA	SER	8.3kJPN chr4:74277714 rs1339083689	-	0.0001	0.0907	-
218_ARG	HIS	VAR_000514 rs75002628	LP/P	-	0.1194	Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
218_ARG	PRO	VAR_013013 rs75002628	LP/P	-	0.9256	Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
218_ARG	PRO	ClinVar chr4:74277724 rs75002628	Pathogenic	-	0.9256	Hyperthyroxinemia, familial dysalbuminemic [MONDO:MONDO:0014448,MedGen:C0342185,OMIM:615999]
218_ARG	HIS	8.3kJPN chr4:74277724 rs75002628	-	0.0001	0.1194	-
225_LYS	GLN	VAR_000515 rs79804069	LB/B	-	0.1445	-
240_LYS	GLU	VAR_000516 rs79377490	LB/B	-	0.2466	-
267_ASN	LYS	8.3kJPN chr4:74279166 -	-	0.0002	0.311	-
268_GLN	ARG	VAR_000517 rs80002911	LB/B	-	0.1286	-
269_ASP	GLY	VAR_000518 rs79744198	LB/B	-	0.1121	-
269_ASP	GLY	8.3kJPN chr4:74279171 rs79744198	-	0.0003	0.1121	-
276_LYS	ASN	VAR_000519 rs74718349	LB/B	-	0.3778	-
282_PRO	LEU	gnomAD chr4:74279210 rs755199533	-	0.000198885	0.346	-
282_PRO	LEU	8.3kJPN chr4:74279210 rs755199533	-	0.0001	0.346	-
296_ASP	GLU	8.3kJPN chr4:74279253 -	-	0.0006	0.5472	-
300_ALA	PRO	8.3kJPN chr4:74279263 rs201904433	-	0.0001	0.113	-
313_LYS	ASN	VAR_000520 rs72552710	LB/B	-	0.3203	-
314_ASP	GLY	VAR_013014 rs76242087	LB/B	-	0.215	-
314_ASP	VAL	VAR_013015 rs76242087	LB/B	-	0.324	-
318_ASN	LYS	VAR_000521 rs77544362	LB/B	-	0.4231	-
320_ALA	THR	VAR_000522 rs78953271	LB/B	-	0.069	-
321_GLU	LYS	VAR_000523 rs72552711	LB/B	-	0.2073	-
333_GLU	LYS	VAR_000524 rs77354753	LB/B	-	0.8085	-
334_TYR	CYS	8.3kJPN chr4:74280766 rs537985931	-	0.0001	0.6013	-
352_THR	ILE	8.3kJPN chr4:74280820 rs767733978	-	0.0001	0.1508	-
354_GLU	LYS	VAR_000525 rs76593094	LB/B	-	0.7051	-
354_GLU	LYS	8.3kJPN chr4:74280825 rs76593094	-	0.0001	0.7051	-
355_THR	ASN	8.3kJPN chr4:74280829 -	-	0.0001	0.0643	-
358_GLU	LYS	VAR_000526 rs75791663	LB/B	-	0.2462	-
359_LYS	ASN	VAR_013016 rs75069738	LB/B	-	0.1979	-
359_LYS	ARG	8.3kJPN chr4:74280841 rs1220544264	-	0.0001	0.0965	-
363_ALA	SER	gnomAD chr4:74280852 rs149483745	-	0.000123362	0.0739	-
363_ALA	THR	8.3kJPN chr4:74280852 rs149483745	-	0.0001	0.0577	-
365_ASP	HIS	VAR_000527 rs77187142	LB/B	-	0.2836	-
365_ASP	VAL	VAR_000528 rs78538497	LB/B	-	0.2332	-
369_CYS	ARG	8.3kJPN chr4:74280870 -	-	0.0001	0.9671	-
372_LYS	GLU	VAR_000529 rs78166690	LB/B	-	0.1555	-
375_ASP	ASN	VAR_000530 rs77514449	LB/B	-	0.1121	-
375_ASP	ASN	8.3kJPN chr4:74281976 rs77514449	-	0.0002	0.1121	-
376_GLU	LYS	VAR_000531 rs79047363	LB/B	-	0.1505	-
376_GLU	GLN	VAR_000532 rs79047363	LB/B	-	0.1213	-
382_GLU	LYS	VAR_000533 rs76483862	LB/B	-	0.1407	-
384_PRO	LEU	8.3kJPN chr4:74282004 -	-	0.0001	0.6482	-
389_LYS	GLN	8.3kJPN chr4:74282018 -	-	0.0001	0.0937	-
396_GLU	LYS	VAR_014294 -	LB/B	-	0.1538	-
403_PHE	LEU	8.3kJPN chr4:74282060 -	-	0.0001	0.9854	-
406_ALA	VAL	8.3kJPN chr4:74282070 rs370819889	-	0.0001	0.148	-
410_ARG	CYS	VAR_013017 rs78575701	LB/B	-	0.5955	-
410_ARG	HIS	8.3kJPN chr4:74283259 rs921029989	-	0.0001	0.2291	-
431_GLY	ALA	8.3kJPN chr4:74283322 rs767335300	-	0.0001	0.2487	-
436_LYS	TER	ClinVar chr4:74283336 -	Pathogenic	-	-	not provided [MedGen:C3661900]
466_LYS	GLU	VAR_014295 rs1063469	LB/B	-	0.3701	-
467_THR	MET	8.3kJPN chr4:74283848 rs776185501	-	0.0001	0.1147	-
479_GLU	LYS	VAR_000534 rs80259813	LB/B	-	0.1933	-
485_ARG	GLN	gnomAD chr4:74283902 rs200002649	-	0.0001313	0.4197	-
494_ASP	ASN	VAR_000535 rs75920790	LB/B	-	0.4854	-
501_GLU	LYS	VAR_000536 rs75523493	LB/B	-	0.1237	-
501_GLU	LYS	gnomAD chr4:74283949 rs75523493	-	0.000135334	0.1237	-
505_GLU	LYS	VAR_000537 rs74826639	LB/B	-	0.1511	-
527_THR	ILE	8.3kJPN chr4:74284028 rs149079814	-	0.0006	0.197	-
533_VAL	MET	VAR_013018 rs78284052	LB/B	-	0.3933	-
533_VAL	MET	gnomAD chr4:74285240 rs78284052	-	0.000271236	0.3933	-
536_LYS	GLU	VAR_000538 rs77645174	LB/B	-	0.6077	-
541_LYS	GLU	VAR_000539 rs80345158	LB/B	-	0.0572	-
541_LYS	GLU	ClinVar chr4:74285264 rs80345158	Pathogenic	-	0.0572	not specified [MedGen:CN169374]
545_LYS	GLU	8.3kJPN chr4:74285276 rs72552712	-	0.0001	0.1302	-
550_ASP	GLY	VAR_000540 rs79738788	LB/B	-	0.1348	-
550_ASP	ALA	VAR_000541 rs79738788	LB/B	-	0.1925	-
550_ASP	GLY	gnomAD chr4:74285292 rs79738788	-	0.0011262	0.1348	-
560_LYS	GLU	VAR_013019 rs76671808	LB/B	-	0.105	-
563_ASP	ASN	VAR_000542 rs76587671	LB/B	-	0.0906	-
565_GLU	LYS	VAR_000543 rs75709682	LB/B	-	0.3444	-
570_GLU	LYS	VAR_000544 rs79228041	LB/B	-	0.1085	-
570_GLU	LYS	ClinVar chr4:74285351 rs79228041	Pathogenic	-	0.1085	ALBUMIN B [-]
573_LYS	GLU	VAR_000545 rs80106970	LB/B	-	0.0839	-
574_LYS	ASN	VAR_000546 rs75738598	LB/B	-	0.1944	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

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Sequence information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Variants

Reference

	P61769	Beta-2-microglobulin
	P55899	IgG receptor FcRn large subunit p51

	5FUO	FAB HEAVY CHAIN
	5FUO	FAB LIGHT CHAIN

	P02768	Serum albumin
	P02768	Serum albumin