PDB ID 1AO6     CHAIN A
Protein name SERUM ALBUMIN
Uniprot Accession P02768
The number of similar proteins 152
The number of binding states 8
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1AO6 (CHAIN: A)
1 Monomeric state
2 P02768  
3 4HGK  
4 5VNW  
5 6ZL1  
6 P61769   P55899  
7 5FUO   5FUO  
8 P02768   P02768  

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Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   DAHKSEVAHR   FKDLGEENFK   ALVLIAFAQY   LQQCPFEDHV   KLVNEVTEFA   50
51   KTCVADESAE   NCDKSLHTLF   GDKLCTVATL   RETYGEMADC   CAKQEPERNE   100
101   CFLQHKDDNP   NLPRLVRPEV   DVMCTAFHDN   EETFLKKYLY   EIARRHPYFY   150
151   APELLFFAKR   YKAAFTECCQ   AADKAACLLP   KLDELRDEGK   ASSAKQRLKC   200
201   ASLQKFGERA   FKAWAVARLS   QRFPKAEFAE   VSKLVTDLTK   VHTECCHGDL   250
251   LECADDRADL   AKYICENQDS   ISSKLKECCE   KPLLEKSHCI   AEVENDEMPA   300
301   DLPSLAADFV   ESKDVCKNYA   EAKDVFLGMF   LYEYARRHPD   YSVVLLLRLA   350
351   KTYETTLEKC   CAAADPHECY   AKVFDEFKPL   VEEPQNLIKQ   NCELFEQLGE   400
401   YKFQNALLVR   YTKKVPQVST   PTLVEVSRNL   GKVGSKCCKH   PEAKRMPCAE   450
451   DYLSVVLNQL   CVLHEKTPVS   DRVTKCCTES   LVNRRPCFSA   LEVDETYVPK   500
501   EFNAETFTFH   ADICTLSEKE   RQIKKQTALV   ELVKHKPKAT   KEQLKAVMDD   550
551   FAAFVEKCCK   ADDKETCFAE   EGKKLVAASQ   AALGL     600

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
32_GLN TER ClinVar
chr4:74272374
rs75470261
Pathogenic - Analbuminemia [MedGen:C0878666,OMIM:616000,Orphanet:86816]
49_PHE TYR VAR_010657 -
LB/B - -
59_ALA VAL gnomAD
chr4:74272456
rs200736287
- 0.000378338 -
60_GLU LYS VAR_000507 rs77050410
LB/B - -
63_ASP ASN VAR_000508 rs78574148
LB/B - -
66_LEU PRO VAR_013011 rs77892378
LP/P - Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
66_LEU PRO ClinVar
chr4:74272477
rs77892378
Pathogenic - Hyperthyroxinemia, familial dysalbuminemic [MONDO:MONDO:0014448,MedGen:C0342185,OMIM:615999]
82_GLU LYS VAR_000509 rs80296402
LB/B - -
84_TYR CYS gnomAD
chr4:74274363
rs142714816
- 0.000517236 -
97_GLU GLY VAR_014290 -
LB/B - -
97_GLU GLY 8.3kJPN
chr4:74274402
-
- 0.0001 -
111_ASN LYS 8.3kJPN
chr4:74274445
-
- 0.0001 -
114_ARG GLY VAR_000510 rs77238412
LB/B - -
114_ARG TER ClinVar
chr4:74274452
rs77238412
Pathogenic - Analbuminemia|not provided [MedGen:C0878666,OMIM:616000,Orphanet:86816|MedGen:C3661900]
119_GLU LYS VAR_000511 rs75522063
LB/B - -
122_VAL GLU VAR_013012 rs77752336
LB/B - -
128_HIS ARG VAR_000512 rs80095457
LB/B - -
134_PHE LEU 8.3kJPN
chr4:74274514
-
- 0.0001 -
153_GLU ASP gnomAD
chr4:74275120
rs149432908
- 0.000441805 -
171_ALA PRO 8.3kJPN
chr4:74275172
-
- 0.0001 -
177_CYS PHE VAR_000513 rs77656691
LB/B - -
191_ALA THR VAR_014291 rs3210154
LB/B - -
191_ALA VAL VAR_014292 rs3204504
LB/B - -
196_GLN LEU VAR_014293 rs3210163
LB/B - -
202_SER ARG 8.3kJPN
chr4:74276089
rs763471006
- 0.0001 -
214_TRP TER ClinVar
chr4:74277713
rs76454301
Pathogenic - Analbuminemia [MedGen:C0878666,OMIM:616000,Orphanet:86816]
215_ALA SER 8.3kJPN
chr4:74277714
rs1339083689
- 0.0001 -
218_ARG HIS VAR_000514 rs75002628
LP/P - Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
218_ARG PRO VAR_013013 rs75002628
LP/P - Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]
218_ARG PRO ClinVar
chr4:74277724
rs75002628
Pathogenic - Hyperthyroxinemia, familial dysalbuminemic [MONDO:MONDO:0014448,MedGen:C0342185,OMIM:615999]
218_ARG HIS 8.3kJPN
chr4:74277724
rs75002628
- 0.0001 -
225_LYS GLN VAR_000515 rs79804069
LB/B - -
240_LYS GLU VAR_000516 rs79377490
LB/B - -
267_ASN LYS 8.3kJPN
chr4:74279166
-
- 0.0002 -
268_GLN ARG VAR_000517 rs80002911
LB/B - -
269_ASP GLY VAR_000518 rs79744198
LB/B - -
269_ASP GLY 8.3kJPN
chr4:74279171
rs79744198
- 0.0003 -
276_LYS ASN VAR_000519 rs74718349
LB/B - -
282_PRO LEU gnomAD
chr4:74279210
rs755199533
- 0.000198885 -
282_PRO LEU 8.3kJPN
chr4:74279210
rs755199533
- 0.0001 -
296_ASP GLU 8.3kJPN
chr4:74279253
-
- 0.0006 -
300_ALA PRO 8.3kJPN
chr4:74279263
rs201904433
- 0.0001 -
313_LYS ASN VAR_000520 rs72552710
LB/B - -
314_ASP GLY VAR_013014 rs76242087
LB/B - -
314_ASP VAL VAR_013015 rs76242087
LB/B - -
318_ASN LYS VAR_000521 rs77544362
LB/B - -
320_ALA THR VAR_000522 rs78953271
LB/B - -
321_GLU LYS VAR_000523 rs72552711
LB/B - -
333_GLU LYS VAR_000524 rs77354753
LB/B - -
334_TYR CYS 8.3kJPN
chr4:74280766
rs537985931
- 0.0001 -
352_THR ILE 8.3kJPN
chr4:74280820
rs767733978
- 0.0001 -
354_GLU LYS VAR_000525 rs76593094
LB/B - -
354_GLU LYS 8.3kJPN
chr4:74280825
rs76593094
- 0.0001 -
355_THR ASN 8.3kJPN
chr4:74280829
-
- 0.0001 -
358_GLU LYS VAR_000526 rs75791663
LB/B - -
359_LYS ASN VAR_013016 rs75069738
LB/B - -
359_LYS ARG 8.3kJPN
chr4:74280841
rs1220544264
- 0.0001 -
363_ALA SER gnomAD
chr4:74280852
rs149483745
- 0.000123362 -
363_ALA THR 8.3kJPN
chr4:74280852
rs149483745
- 0.0001 -
365_ASP HIS VAR_000527 rs77187142
LB/B - -
365_ASP VAL VAR_000528 rs78538497
LB/B - -
369_CYS ARG 8.3kJPN
chr4:74280870
-
- 0.0001 -
372_LYS GLU VAR_000529 rs78166690
LB/B - -
375_ASP ASN VAR_000530 rs77514449
LB/B - -
375_ASP ASN 8.3kJPN
chr4:74281976
rs77514449
- 0.0002 -
376_GLU LYS VAR_000531 rs79047363
LB/B - -
376_GLU GLN VAR_000532 rs79047363
LB/B - -
382_GLU LYS VAR_000533 rs76483862
LB/B - -
384_PRO LEU 8.3kJPN
chr4:74282004
-
- 0.0001 -
389_LYS GLN 8.3kJPN
chr4:74282018
-
- 0.0001 -
396_GLU LYS VAR_014294 -
LB/B - -
403_PHE LEU 8.3kJPN
chr4:74282060
-
- 0.0001 -
406_ALA VAL 8.3kJPN
chr4:74282070
rs370819889
- 0.0001 -
410_ARG CYS VAR_013017 rs78575701
LB/B - -
410_ARG HIS 8.3kJPN
chr4:74283259
rs921029989
- 0.0001 -
431_GLY ALA 8.3kJPN
chr4:74283322
rs767335300
- 0.0001 -
436_LYS TER ClinVar
chr4:74283336
-
Pathogenic - not provided [MedGen:C3661900]
466_LYS GLU VAR_014295 rs1063469
LB/B - -
467_THR MET 8.3kJPN
chr4:74283848
rs776185501
- 0.0001 -
479_GLU LYS VAR_000534 rs80259813
LB/B - -
485_ARG GLN gnomAD
chr4:74283902
rs200002649
- 0.0001313 -
494_ASP ASN VAR_000535 rs75920790
LB/B - -
501_GLU LYS VAR_000536 rs75523493
LB/B - -
501_GLU LYS gnomAD
chr4:74283949
rs75523493
- 0.000135334 -
505_GLU LYS VAR_000537 rs74826639
LB/B - -
527_THR ILE 8.3kJPN
chr4:74284028
rs149079814
- 0.0006 -
533_VAL MET VAR_013018 rs78284052
LB/B - -
533_VAL MET gnomAD
chr4:74285240
rs78284052
- 0.000271236 -
536_LYS GLU VAR_000538 rs77645174
LB/B - -
541_LYS GLU VAR_000539 rs80345158
LB/B - -
541_LYS GLU ClinVar
chr4:74285264
rs80345158
Pathogenic - not specified [MedGen:CN169374]
545_LYS GLU 8.3kJPN
chr4:74285276
rs72552712
- 0.0001 -
550_ASP GLY VAR_000540 rs79738788
LB/B - -
550_ASP ALA VAR_000541 rs79738788
LB/B - -
550_ASP GLY gnomAD
chr4:74285292
rs79738788
- 0.0011262 -
560_LYS GLU VAR_013019 rs76671808
LB/B - -
563_ASP ASN VAR_000542 rs76587671
LB/B - -
565_GLU LYS VAR_000543 rs75709682
LB/B - -
570_GLU LYS VAR_000544 rs79228041
LB/B - -
570_GLU LYS ClinVar
chr4:74285351
rs79228041
Pathogenic - ALBUMIN B [-]
573_LYS GLU VAR_000545 rs80106970
LB/B - -
574_LYS ASN VAR_000546 rs75738598
LB/B - -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.