PDB ID 1ALY     CHAIN A
Protein name CD40 LIGAND
Uniprot Accession P29965
The number of similar proteins 17
The number of binding states 7
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1ALY (CHAIN: A)
1 Monomeric state
2 6BRB  
3 P29965   P29965  
4 P29965   P29965   P25942  
5 P29965   P29965   1I9R   1I9R  
6 P29965   P29965   P25942   P25942  
7 P29965   P29965   7SGM   7SGM   7SGM  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GDQNPQIAAH   VISEASSKTT   SVLQWAEKGY   YTMSNNLVTL   ENGKQLTVKR   50
51   QGLYYIYAQV   TFCSNREASS   QAPFIASLCL   KSPGRFERIL   LRAANTHSSA   100
101   KPCGQQSIHL   GGVFELQPGA   SVFVNVTDPS   QVSHGTGFTS   FGLLKL   150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
116_GLY ARG VAR_017929 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
116_GLY SER VAR_017930 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
116_GLY CYS ClinVar
chrX:135736589 		rs2148552406
Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
123_ALA GLU VAR_007514 rs104894778
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
123_ALA GLU ClinVar
chrX:135738536 		rs104894778
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
123_ALA VAL 8.3kJPN
chrX:135738536 		rs104894778
- 0.0002 -
125_HIS ARG VAR_017926 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
125_HIS TYR ClinVar
chrX:135738541 		rs1603321148
Pathogenic/Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
126_VAL ALA VAR_007515 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
126_VAL ASP VAR_017931 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
129_GLU TER ClinVar
chrX:135738553 		rs1215852570
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
138_LEU SER ClinVar
chrX:135741201 		-
Likely pathogenic - not provided [MedGen:C3661900]
140_TRP CYS VAR_007517 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
140_TRP GLY VAR_007518 rs104894777
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
140_TRP ARG VAR_007519 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
140_TRP TER ClinVar
chrX:135741207 		rs104894775
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
140_TRP GLY ClinVar
chrX:135741206 		rs104894777
Likely pathogenic - Hyper-IgM syndrome type 1|not provided [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088|MedGen:C3661900]
140_TRP ARG ClinVar
chrX:135741206 		rs104894777
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
140_TRP CYS ClinVar
chrX:135741208 		-
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
141_ALA PRO ClinVar
chrX:135741209 		rs1387503550
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
141_ALA THR 8.3kJPN
chrX:135741209 		rs1387503550
- 0.0004 -
143_LYS THR VAR_017932 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
144_GLY GLU VAR_007520 rs886039326
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
144_GLY GLU ClinVar
chrX:135741219 		rs886039326
Likely pathogenic - not provided|Hyper-IgM syndrome type 1 [MedGen:C3661900|MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
144_GLY TER ClinVar
chrX:135741218 		-
Likely pathogenic - not provided [MedGen:CN517202]
146_TYR TER ClinVar
chrX:135741226 		-
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
147_THR ASN VAR_017922 rs1057521127
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
155_LEU PRO VAR_007521 rs104894769
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
155_LEU PRO ClinVar
chrX:135741252 		rs104894769
Pathogenic - Hyper-IgM syndrome type 1|not provided [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088|MedGen:C3661900]
155_LEU GLN ClinVar
chrX:135741252 		rs104894769
Likely pathogenic - not provided [MedGen:CN517202]
160_GLN TER ClinVar
chrX:135741266 		rs767889061
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
163_VAL ILE gnomAD
chrX:135741275 		rs199914973
- 0.00013661 -
167_GLY ARG ClinVar
chrX:135741287 		-
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
169_TYR CYS ClinVar
chrX:135741294 		rs786205606
Likely pathogenic - not provided [MedGen:C3661900]
170_TYR CYS VAR_017923 rs756468554
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
170_TYR TER ClinVar
chrX:135741298 		-
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
170_TYR CYS ClinVar
chrX:135741297 		-
Likely pathogenic - not provided [MedGen:CN517202]
172_TYR HIS ClinVar
chrX:135741302 		rs2076127133
Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
172_TYR CYS ClinVar
chrX:135741303 		-
Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
173_ALA ASP VAR_017933 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
174_GLN ARG VAR_017927 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
174_GLN TER ClinVar
chrX:135741308 		rs1603321772
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
176_THR ILE VAR_017934 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
181_ARG GLN gnomAD
chrX:135741330 		rs11575982
- 0.00183427 -
186_GLN TER ClinVar
chrX:135741344 		rs2076127276
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
195_LEU PRO VAR_017935 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
199_GLY SER 8.3kJPN
chrX:135741383 		rs769728462
- 0.0002 -
200_ARG TER ClinVar
chrX:135741386 		rs2148553738
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
201_PHE LEU gnomAD
chrX:135741389 		rs144827029
- 0.000109186 -
202_GLU GLN 8.3kJPN
chrX:135741392 		-
- 0.0001 -
206_LEU PRO ClinVar
chrX:135741405 		-
Likely pathogenic - not provided [MedGen:C3661900]
208_ALA ASP VAR_017936 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
211_THR ASN VAR_007522 rs1569377829
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
211_THR ASN ClinVar
chrX:135741420 		rs1569377829
Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
218_CYS TER ClinVar
chrX:135741442 		-
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
219_GLY ARG VAR_007523 rs148594123
LB/B - -
219_GLY ARG gnomAD
chrX:135741443 		rs148594123
- 0.0110849 -
220_GLN TER ClinVar
chrX:135741446 		rs1085307733
Pathogenic - not provided|Hyper-IgM syndrome type 1 [MedGen:C3661900|MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
221_GLN TER ClinVar
chrX:135741449 		rs1603321834
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
224_HIS TYR VAR_017937 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
225_LEU SER ClinVar
chrX:135741462 		rs2148553773
Likely pathogenic - not provided [MedGen:C3661900]
226_GLY ALA VAR_017938 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
227_GLY VAL VAR_007524 rs104894768
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
227_GLY VAL ClinVar
chrX:135741468 		rs104894768
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
229_PHE LEU ClinVar
chrX:135741475 		rs2148553785
Pathogenic - not provided [MedGen:C3661900]
229_PHE LEU ClinVar
chrX:135741475 		-
Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
231_LEU SER VAR_007526 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
232_GLN TER ClinVar
chrX:135741482 		rs2076127875
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
235_ALA PRO VAR_007527 rs104894771
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
235_ALA PRO ClinVar
chrX:135741491 		rs104894771
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
237_VAL GLU VAR_017939 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
254_THR MET VAR_007528 rs193922136
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
254_THR MET ClinVar
chrX:135741549 		rs193922136
Pathogenic - Hyper-IgM syndrome type 1|Hyperimmunoglobulin M syndrome [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088|MONDO:MONDO:0003947,MedGen:C0272236,OMIM:PS308230]
254_THR LYS ClinVar
chrX:135741549 		rs193922136
Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
256_PHE SER ClinVar
chrX:135741555 		rs1057521128
Likely pathogenic - not provided|Hyper-IgM syndrome type 1 [MedGen:C3661900|MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
257_GLY SER VAR_017928 -
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
257_GLY ASP VAR_017940 rs1477466218
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
257_GLY ASP ClinVar
chrX:135741558 		rs1477466218
Pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
257_GLY VAL ClinVar
chrX:135741558 		-
Likely pathogenic - Hyper-IgM syndrome type 1 [MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088]
258_LEU SER VAR_017924 rs1569377884
LP/P - Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.