PDB ID 1AK4     CHAIN A
Protein name CYCLOPHILIN A
Uniprot Accession P62937
The number of similar proteins 160
The number of binding states 7
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1AK4 (CHAIN: A)
1 Q72497  
2 Monomeric state
3 2XGY  
4 P05092  
5 P63098   Q08209  
6 P63098   P63098   Q08209   Q08209  
7 P62937   P62937   P62937   P62937  

Downdload

Format:

Molecule viewer

#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MVNPTVFFDI   AVDGEPLGRV   SFELFADKVP   KTAENFRALS   TGEKGFGYKG   50
51   SCFHRIIPGF   MCQGGDFTRH   NGTGGKSIYG   EKFEDENFIL   KHTGPGILSM   100
101   ANAGPNTNGS   QFFICTAKTE   WLDGKHVVFG   KVKEGMNIVE   AMERFGSRNG   150
151   KTSKKITIAD   CGQLE         200

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
1_MET THR 4.7kJPN
chr1:143767847
-
- 0.0001 -
1_MET VAL 4.7kJPN
chr1:143767848
-
- 0.0001 -
6_ILE VAL 4.7kJPN
chr1:143767833
rs1553321608
- 0.5 -
12_VAL ILE 4.7kJPN
chr1:143767815
rs587775476
- 0.0003 -
17_LEU SER 4.7kJPN
chr1:143767799
-
- 0.0001 -
20_ILE SER 4.7kJPN
chr1:148202403
-
- 0.0001 -
23_LYS GLU 4.7kJPN
chr1:143767782
rs782571429
- 0.0002 -
24_GLN LEU 4.7kJPN
chr1:143767778
rs1553321587
- 0.5 -
24_LEU GLN 4.7kJPN
chr1:148202391
rs1310895899
- 0.0001 -
26_ALA SER 4.7kJPN
chr1:143767773
rs1556172662
- 0.0006 -
30_LEU PRO 4.7kJPN
chr1:144364083
rs1553277153
- 0.3035 -
30_LEU PRO 4.7kJPN
chr1:147955256
rs199950315
- 0.0858 -
31_LYS ASN 4.7kJPN
chr1:143767756
-
- 0.0001 -
33_ALA GLU 4.7kJPN
chr1:147955247
-
- 0.0002 -
37_ARG HIS 4.7kJPN
chr1:148202352
rs1179581919
- 0.0005 -
47_ARG CYS 4.7kJPN
chr1:143767710
rs267597992
- 0.0001 -
47_ARG HIS 4.7kJPN
chr1:148202322
rs1450763932
- 0.0001 -
47_ARG HIS 4.7kJPN
chr1:149553217
rs1385929705
- 0.0014 -
50_GLY ALA 4.7kJPN
chr7:44839039
-
- 0.0001 -
64_GLY VAL 4.7kJPN
chr1:147955154
-
- 0.0003 -
65_GLY SER 4.7kJPN
chr1:143767656
rs1556172429
- 0.0002 -
68_THR LYS 4.7kJPN
chr1:147955142
-
- 0.0002 -
69_HIS ARG 4.7kJPN
chr1:143767643
rs1553321535
- 0.4859 -
69_HIS TYR 4.7kJPN
chr1:143767644
rs370416528
- 0.0877 -
69_ARG CYS 4.7kJPN
chr1:144363967
-
- 0.002 -
69_ARG CYS 4.7kJPN
chr1:147955140
rs587632258
- 0.0003 -
70_HIS PRO 4.7kJPN
chr1:144363963
rs1556598650
- 0.0099 -
70_PRO HIS 4.7kJPN
chr1:148202253
rs1300338652
- 0.0002 -
72_GLY CYS 4.7kJPN
chr1:148202248
-
- 0.0001 -
73_THR ALA 4.7kJPN
chr1:148202245
rs1275248152
- 0.0001 -
74_GLY ASP 4.7kJPN
chr1:143767628
rs1553321523
- 0.4193 -
74_GLY SER 4.7kJPN
chr1:143767629
rs1553321527
- 0.0002 -
74_GLY ASP 4.7kJPN
chr1:148202241
rs201764814
- 0.0115 -
75_ASP GLU 4.7kJPN
chr1:143767624
rs587732257
- 0.0003 -
80_GLY TRP 4.7kJPN
chr1:148202224
rs1283212414
- 0.0016 -
85_ASP ASN 4.7kJPN
chr1:147955092
rs1553321503
- 0.0002 -
88_LEU ILE 4.7kJPN
chr1:143767587
rs1556172248
- 0.0001 -
90_ARG TER 4.7kJPN
chr1:143767581
rs782007857
- 0.0001 -
90_ARG TER 4.7kJPN
chr1:147955077
rs1346295031
- 0.0002 -
94_GLY ASP 4.7kJPN
chr1:143767568
rs377521864
- 0.0003 -
101_ALA VAL 4.7kJPN
chr1:143767547
rs1553321483
- 0.4772 -
101_ALA VAL 4.7kJPN
chr1:144363870
-
- 0.0236 -
101_ALA VAL 4.7kJPN
chr1:148202160
rs781828336
- 0.0024 -
106_ASN SER 4.7kJPN
chr1:147955028
-
- 0.0001 -
108_ASN SER 4.7kJPN
chr1:148202139
rs1469676804
- 0.0004 -
112_PHE LEU 4.7kJPN
chr1:143767513
rs1553321469
- 0.4862 -
112_PHE LEU 4.7kJPN
chr1:144363836
-
- 0.0434 -
112_PHE LEU 4.7kJPN
chr1:148202126
rs1553648642
- 0.001 -
116_THR ASN 4.7kJPN
chr1:143767502
-
- 0.0002 -
116_ALA THR 4.7kJPN
chr1:144363826
-
- 0.223 -
116_ALA THR 4.7kJPN
chr1:149553423
rs2451640
- 0.0045 -
125_LYS ARG 4.7kJPN
chr1:143767475
rs1556171815
- 0.0003 -
128_ALA VAL 4.7kJPN
chr1:143767466
rs1553321459
- 0.3054 -
132_VAL LEU 4.7kJPN
chr1:143767455
-
- 0.0001 -
138_ILE THR 4.7kJPN
chr1:143767436
-
- 0.0001 -
142_THR MET 4.7kJPN
chr1:148202037
rs61809243
- 0.0073 -
148_ARG GLY 4.7kJPN
chr1:143767407
rs781956310
- 0.0013 -
153_SER ARG 4.7kJPN
chr1:143767390
rs782408303
- 0.0002 -
162_GLY ARG 4.7kJPN
chr1:147954861
rs1553321430
- 0.0006 -
164_PHE LEU 4.7kJPN
chr1:143767357
rs201648411
- 0.1051 -
164_PHE LEU 4.7kJPN
chr1:144363680
-
- 0.0057 -
164_PHE LEU 4.7kJPN
chr1:147954853
rs1192310738
- 0.0023 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.