PDB ID 1AH1     CHAIN A
Protein name CTLA-4
Uniprot Accession P16410
The number of similar proteins 10
The number of binding states 6
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1AH1 (CHAIN: A)
1 Monomeric state
2 P16410  
3 P33681  
4 P16410   P42081  
5 5GGV   5GGV  
6 P16410   3BX7  

Downdload

Format:

Molecule viewer

#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   AMHVAQPAVV   LASSRGIASF   VCEYASPGKA   TEVRVTVLRQ   ADSQVTEVCA   50
51   ATYMMGNELT   FLDDSICTGT   SSGNQVNLTI   QGLRAMDTGL   YICKVELMYP   100
101   PPYYLGIGNG   TQIYVIDPEP   CPDSDQEPK       150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
3_VAL MET ClinVar
chr2:204735317
rs1553657378
Likely pathogenic - Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
14_ARG TER ClinVar
chr2:204735350
rs606231417
Pathogenic - Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
17_ALA THR ClinVar
chr2:204735359
rs1553657387
Likely pathogenic - Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
33_ARG TRP VAR_072681 rs606231422
Disease - Autoimmune lymphoproliferative syndrome 5 (ALPS5) [MIM:616100]
45_THR ILE 4.7kJPN
chr2:204735444
-
- 0.0001 -
103_PRO THR ClinVar
chr2:204735611
rs1553657430
Pathogenic - Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
105_TYR TER ClinVar
chr2:204735619
rs1357409506
Pathogenic - Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.