PiSITE

PDB ID	1AH1	CHAIN	A
Protein name	CTLA-4
Uniprot Accession	P16410
The number of similar proteins	10
The number of binding states	6
The number of binding partners	5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1AH1 (CHAIN: A)
1	Monomeric state
2	P16410
3	P33681
4	P16410 P42081
5	5GGV 5GGV
6	P16410 3BX7

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Molecule viewer

#binding
partners

	5
	4
	3
	2
	1
	0

Sequence information

1

AMHVAQPAVV

LASSRGIASF

VCEYASPGKA

TEVRVTVLRQ

ADSQVTEVCA

50

51

ATYMMGNELT

FLDDSICTGT

SSGNQVNLTI

QGLRAMDTGL

YICKVELMYP

100

101

PPYYLGIGNG

TQIYVIDPEP

CPDSDQEPK

150

Variants

	Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (4.7kJPN)	Disease name
	3_VAL	MET	ClinVar chr2:204735317	rs1553657378	Likely pathogenic	-	Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
	14_ARG	TER	ClinVar chr2:204735350	rs606231417	Pathogenic	-	Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
	17_ALA	THR	ClinVar chr2:204735359	rs1553657387	Likely pathogenic	-	Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
	33_ARG	TRP	VAR_072681	rs606231422	Disease	-	Autoimmune lymphoproliferative syndrome 5 (ALPS5) [MIM:616100]
	45_THR	ILE	4.7kJPN chr2:204735444	-	-	0.0001	-
	103_PRO	THR	ClinVar chr2:204735611	rs1553657430	Pathogenic	-	Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]
	105_TYR	TER	ClinVar chr2:204735619	rs1357409506	Pathogenic	-	Autoimmune lymphoproliferatiVe syndrome, type V [MedGen:C4015214,OMIM:616100,Orphanet:ORPHA436159]

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364