| PDB ID | 1AGR
|
CHAIN | A |
|---|---|---|---|
| Protein name | GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) | ||
| Uniprot Accession | P10824 | ||
| The number of similar proteins | 56 | ||
| The number of binding states | 6 | ||
| The number of binding partners | 6 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1AGR (CHAIN: A) | |
| 1 |
P49799
|
| 2 | Monomeric state |
| 3 |
P62871
|
| 4 |
P10824
|
| 5 |
O43566
|
| 6 |
P62873
6CRK
P59768
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source | dbSNP | Clinical Significance |
Allele Frequency (> 0.0001) |
Disease name | |
|---|---|---|---|---|---|---|---|
| 21_ARG | HIS |
gnomAD chr1:110091404 |
rs758232853
|
- | 0.000390908 | - | |
| 40_GLY | ARG |
ClinVar chr1:110091460 |
rs387907178
|
Pathogenic | - | Auriculocondylar syndrome 1 [MedGen:C4551996,OMIM:602483] | |
| 47_SER | ARG |
ClinVar chr1:110116381 |
rs397514768
|
Pathogenic | - | Auriculocondylar syndrome 1 [MedGen:C4551996,OMIM:602483] | |
| 67_ARG | TRP |
8.3kJPN chr3:50289866 |
rs782461705
|
- | 0.0001 | - | |
| 70_ARG | GLN |
8.3kJPN chr3:50289876 |
rs782573516
|
- | 0.0001 | - | |
| 90_ARG | TRP |
gnomAD chr1:110116624 |
rs145097404
|
- | 0.000216171 | - | |
| 90_ARG | GLN |
gnomAD chr1:110116625 |
rs138850957
|
- | 0.000228925 | - | |
| 90_ARG | TRP |
8.3kJPN chr1:110116624 |
rs145097404
|
- | 0.004 | - | |
| 94_ASP | ASN |
gnomAD chr3:50289947 |
rs183955200
|
- | 0.000271485 | - | |
| 94_ASP | GLU |
8.3kJPN chr1:110116638 |
-
|
- | 0.0001 | - | |
| 96_ALA | SER |
8.3kJPN chr3:50289953 |
-
|
- | 0.0001 | - | |
| 96_GLY | ASP |
8.3kJPN chr7:79818531 |
rs1283536547
|
- | 0.0003 | - | |
| 102_ASP | GLY |
8.3kJPN chr7:79828542 |
-
|
- | 0.0001 | - | |
| 120_PRO | LEU |
8.3kJPN chr3:50290514 |
-
|
- | 0.0001 | - | |
| 125_GLY | SER |
8.3kJPN chr3:50290528 |
rs782437262
|
- | 0.0001 | - | |
| 126_VAL | ILE |
gnomAD chr3:50290531 |
rs200441316
|
- | 0.000294539 | - | |
| 126_VAL | ILE |
8.3kJPN chr3:50290531 |
rs200441316
|
- | 0.0024 | - | |
| 127_ILE | THR |
gnomAD chr7:79828617 |
rs35545354
|
- | 0.00238226 | - | |
| 128_ARG | TRP |
8.3kJPN chr3:50290537 |
rs180852414
|
- | 0.0008 | - | |
| 155_TYR | ASN |
8.3kJPN chr3:50293625 |
-
|
- | 0.0001 | - | |
| 156_LEU | GLN |
8.3kJPN chr3:50293629 |
-
|
- | 0.0002 | - | |
| 165_PRO | ALA |
8.3kJPN chr7:79833051 |
rs745806214
|
- | 0.0001 | - | |
| 170_THR | ILE |
gnomAD chr1:110125106 |
rs61754626
|
- | 0.000262509 | - | |
| 170_THR | PRO |
8.3kJPN chr1:110125105 |
rs1205497380
|
- | 0.0001 | - | |
| 178_ARG | CYS |
ClinVar chr3:50293694 |
rs137853226
|
Pathogenic | - | Adrenocortical tumor, somatic [MedGen:C4016392]; Granulosa cell tumor of the ovary [MedGen:C1370419]; Thecoma, somatic [MedGen:C2750844] | |
| 178_ARG | HIS |
ClinVar chr3:50293695 |
rs137853227
|
Pathogenic | - | Adrenocortical tumor, somatic [MedGen:C4016392]; Granulosa cell tumor of the ovary [MedGen:C1370419]; Thecoma, somatic [MedGen:C2750844] | |
| 178_ARG | GLY |
ClinVar chr3:50293694 |
rs137853226
|
Pathogenic | - | Pituitary dependent hypercortisolism [MedGen:C0221406,OMIM:219090,SNOMED CT:190502001] | |
| 199_PHE | LEU |
ClinVar chr3:50294161 |
rs137853228
|
Pathogenic | - | Ventricular tachycardia, somatic [MedGen:C4016143] | |
| 264_ILE | VAL |
gnomAD chr1:110129420 |
rs61758986
|
- | 0.000111651 | - | |
| 280_LYS | ARG |
8.3kJPN chr7:79842150 |
-
|
- | 0.0001 | - | |
| 282_PRO | LEU |
8.3kJPN chr1:110129475 |
rs755438174
|
- | 0.0001 | - | |
| 294_ASN | LYS |
8.3kJPN chr3:50294939 |
rs587647183
|
- | 0.0001 | - | |
| 310_LEU | MET |
8.3kJPN chr3:50294985 |
rs1327376805
|
- | 0.0001 | - | |
| 312_LYS | THR |
8.3kJPN chr3:50294992 |
rs1553703449
|
- | 0.0002 | - | |
| 316_THR | SER |
gnomAD chr3:50295004 |
rs372568318
|
- | 0.000145346 | - | |
| 346_ASN | LYS |
8.3kJPN chr7:79846782 |
-
|
- | 0.0001 | - |