PDB ID 1AGR     CHAIN A
Protein name GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)
Uniprot Accession P10824
The number of similar proteins 56
The number of binding states 6
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1AGR (CHAIN: A)
1 P49799  
2 Monomeric state
3 P62871  
4 P10824  
5 O43566  
6 P62873   6CRK   P59768  

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#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   GCTLSAEDKA   AVERSKMIDR   NLREDGEKAA   REVKLLLLGA   GESGKSTIVK   50
51   QMKIIHEAGY   SEEECKQYKA   VVYSNTIQSI   IAIIRAMGRL   KIDFGDAARA   100
101   DDARQLFVLA   GAAEEGFMTA   ELAGVIKRLW   KDSGVQACFN   RSREYQLNDS   150
151   AAYYLNDLDR   IAQPNYIPTQ   QDVLRTRVKT   TGIVETHFTF   KDLHFKMFDV   200
201   GGQRSERKKW   IHCFEGVTAI   IFCVALSDYD   LVLAEDEEMN   RMHESMKLFD   250
251   SICNNKWFTD   TSIILFLNKK   DLFEEKIKKS   PLTICYPEYA   GSNTYEEAAA   300
301   YIQCQFEDLN   KRKDTKEIYT   HFTCATDTKN   VQFVFDAVTD   VIIKNNLKDC   350
351   GLF           400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
40_GLY ARG ClinVar
chr1:110091460
rs387907178
Pathogenic - Auriculocondylar syndrome 1 [MedGen:C4551996,OMIM:602483]
47_SER ARG ClinVar
chr1:110116381
rs397514768
Pathogenic - Auriculocondylar syndrome 1 [MedGen:C4551996,OMIM:602483]
64_GLU ASP 4.7kJPN
chr7:79818436
-
- 0.0001 -
67_ARG TRP 4.7kJPN
chr3:50289866
rs782461705
- 0.0001 -
70_ARG GLN 4.7kJPN
chr3:50289876
rs782573516
- 0.0001 -
70_LYS ARG 4.7kJPN
chr7:79818453
-
- 0.0001 -
90_ARG TRP 4.7kJPN
chr1:110116624
rs145097404
- 0.0039 -
94_ASP GLU 4.7kJPN
chr1:110116638
-
- 0.0001 -
96_ALA SER 4.7kJPN
chr3:50289953
-
- 0.0001 -
96_GLY ASP 4.7kJPN
chr7:79818531
rs1283536547
- 0.0002 -
102_ASP GLY 4.7kJPN
chr7:79828542
-
- 0.0001 -
120_PRO LEU 4.7kJPN
chr3:50290514
-
- 0.0001 -
125_GLY SER 4.7kJPN
chr3:50290528
rs782437262
- 0.0001 -
126_VAL ILE 4.7kJPN
chr3:50290531
rs200441316
- 0.0027 -
128_ARG TRP 4.7kJPN
chr3:50290537
rs180852414
- 0.0007 -
155_TYR ASN 4.7kJPN
chr3:50293625
-
- 0.0001 -
156_LEU GLN 4.7kJPN
chr3:50293629
-
- 0.0001 -
165_PRO ALA 4.7kJPN
chr7:79833051
rs745806214
- 0.0002 -
170_THR PRO 4.7kJPN
chr1:110125105
rs1205497380
- 0.0001 -
178_ARG CYS ClinVar
chr3:50293694
rs137853226
Pathogenic - Adrenocortical tumor, somatic [MedGen:C4016392]; Granulosa cell tumor of the ovary [MedGen:C1370419]; Thecoma, somatic [MedGen:C2750844]
178_ARG HIS ClinVar
chr3:50293695
rs137853227
Pathogenic - Adrenocortical tumor, somatic [MedGen:C4016392]; Granulosa cell tumor of the ovary [MedGen:C1370419]; Thecoma, somatic [MedGen:C2750844]
178_ARG GLY ClinVar
chr3:50293694
rs137853226
Pathogenic - Pituitary dependent hypercortisolism [MedGen:C0221406,OMIM:219090,SNOMED CT:190502001]
199_PHE LEU ClinVar
chr3:50294161
rs137853228
Pathogenic - Ventricular tachycardia, somatic [MedGen:C4016143]
276_GLU LYS 4.7kJPN
chr3:50294474
rs1464427483
- 0.0001 -
280_LYS ARG 4.7kJPN
chr7:79842150
-
- 0.0001 -
294_ASN LYS 4.7kJPN
chr3:50294939
rs587647183
- 0.0001 -
310_LEU MET 4.7kJPN
chr3:50294985
rs1327376805
- 0.0002 -
312_LYS THR 4.7kJPN
chr3:50294992
rs1553703449
- 0.0003 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.