PDB ID 1A8M     CHAIN A
Protein name TUMOR NECROSIS FACTOR ALPHA
Uniprot Accession P01375
The number of similar proteins 54
The number of binding states 11
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Downdload

Format:

Molecule viewer

#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   VRSSSRTPSD   KPVAHVVANP   QAEGQLQWLN   DRANALLANG   VELRDNQLVV   50
51   PSEGLYLIYS   QVLFKGQGCP   STHVLLTHTI   SRIAVSYQTK   VNLLSAIKSP   100
101   CQRETPEGAE   AKPWYEPIYL   GGVFQLEKGD   RLSAEINRPD   YLDFAESGQV   150
151   YFGIIAL           200

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
8_PRO LEU VAR_019378 rs4645843
Polymorphism - -
18_ALA THR VAR_011927 rs1800620
Polymorphism - -
32_ARG TRP ClinVar
chr6:31544934
rs281865419
Pathogenic - TNF receptor binding, altered [MedGen:C4016415]
72_THR SER 4.7kJPN
chr6:31545055
-
- 0.0001 -
85_VAL ILE 4.7kJPN
chr6:31545093
rs373646181
- 0.0003 -
103_ARG LYS 4.7kJPN
chr6:31545148
-
- 0.0001 -
118_ILE ASN 4.7kJPN
chr6:31545193
rs11574936
- 0.0002 -
140_ASP ASN 4.7kJPN
chr6:31545258
rs370893734
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.