PDB ID 1A8M     CHAIN A
Protein name TUMOR NECROSIS FACTOR ALPHA
Uniprot Accession P01375
The number of similar proteins 54
The number of binding states 11
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1A8M (CHAIN: A)
1 P01375   P01375  
2 P01375  
3 3L9J  
4 3WD5   3WD5  
5 P01375   P01375   5M2M  
6 P01375   P01375   P01375  
7 P01375   P01375   5M2I   5M2I  
8 P01375   P01375   5YOY   5YOY  
9 P01375   P01375   Q9DHW0   Q9DHW0  
10 P01375   P01375   P20333   P20333  
11 P01375   P01375   4G3Y   4G3Y   4G3Y  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   VRSSSRTPSD   KPVAHVVANP   QAEGQLQWLN   DRANALLANG   VELRDNQLVV   50
51   PSEGLYLIYS   QVLFKGQGCP   STHVLLTHTI   SRIAVSYQTK   VNLLSAIKSP   100
101   CQRETPEGAE   AKPWYEPIYL   GGVFQLEKGD   RLSAEINRPD   YLDFAESGQV   150
151   YFGIIAL           200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
8_PRO LEU VAR_019378 rs4645843
Polymorphism - -
8_PRO LEU gnomAD
chr6:31544562 		rs4645843
- 0.002562 -
18_ALA THR VAR_011927 rs1800620
Polymorphism - -
32_ARG TRP ClinVar
chr6:31544934 		rs281865419
Pathogenic - TNF receptor binding, altered [MedGen:C4016415]
41_VAL MET 8.3kJPN
chr6:31544961 		rs548532642
- 0.0001 -
72_THR SER 8.3kJPN
chr6:31545055 		-
- 0.0001 -
85_VAL ILE gnomAD
chr6:31545093 		rs373646181
- 0.000101197 -
85_VAL ILE 8.3kJPN
chr6:31545093 		rs373646181
- 0.0002 -
103_ARG LYS 8.3kJPN
chr6:31545148 		-
- 0.0001 -
118_ILE ASN gnomAD
chr6:31545193 		rs11574936
- 0.000352864 -
118_ILE ASN 8.3kJPN
chr6:31545193 		rs11574936
- 0.0004 -
138_ARG GLN 8.3kJPN
chr6:31545253 		rs770509340
- 0.0001 -
140_ASP ASN 8.3kJPN
chr6:31545258 		rs370893734
- 0.0001 -
146_GLU ASP 8.3kJPN
chr6:31545278 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.