PiSITE

PDB ID	2JKR	CHAIN	S
Protein name	AP-2 COMPLEX SUBUNIT SIGMA-1
Uniprot Accession	P62743
The number of similar proteins	12
The number of binding states	7
The number of binding partners	5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	2JKR (CHAIN: S)
1	P84092 P17427
2	Q66HM2
3	P63010 Q66HM2
4	Q66HM2 Q90VU7
5	P84092 P63010 Q66HM2
6	Q66HM2 Q90VU7 Q96CW1
7	P84092 P84092 P63010 Q66HM2

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Only interaction residues

#binding
partners

	3
	2
	1
	0

Sequence information

1

MIRFILIQNR

AGKTRLAKWY

MQFDDDEKQK

LIEEVHAVVT

VRDAKHTNFV

50

51

EFRNFKIIYR

RYAGLYFCIC

VDVNDNNLAY

LEAIHNFVEV

LNEYFHNVCE

100

101

LDLVFNFYKV

YTVVDEMFLA

GEIRETSQTK

VLKQLLMLQS

LE

150

Variants

	Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
	15_ARG	CYS	ClinVar chr19:47349360 rs397514498	Pathogenic	-	-	Familial hypocalciuric hypercalcemia 3\|not provided [MONDO:MONDO:0010926,MedGen:C1833372,OMIM:600740,Orphanet:101050,Orphanet:405\|MedGen:C3661900]
	15_ARG	LEU	ClinVar chr19:47349359 rs397514499	Pathogenic	-	-	Familial hypocalciuric hypercalcemia 3\|not provided [MONDO:MONDO:0010926,MedGen:C1833372,OMIM:600740,Orphanet:101050,Orphanet:405\|MedGen:C3661900]
	15_ARG	HIS	ClinVar chr19:47349359 rs397514499	Pathogenic	-	-	Familial hypocalciuric hypercalcemia 3\|not provided [MONDO:MONDO:0010926,MedGen:C1833372,OMIM:600740,Orphanet:101050,Orphanet:405\|MedGen:C3661900]
	44_ALA	THR	8.3kJPN chr19:47349273 rs539480372	-	0.0001	-	-
	77_ASN	HIS	8.3kJPN chr19:47342760 -	-	0.0001	-	-
	129_THR	MET	8.3kJPN chr19:47341747 -	-	0.0001	-	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364