PiSITE

PDB ID	1BVN	CHAIN	P
Protein name	PROTEIN (ALPHA-AMYLASE)
Uniprot Accession	P00690
The number of similar proteins	17
The number of binding states	5
The number of binding partners	4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1BVN (CHAIN: P)
1	P01092
2	Monomeric state
3	4X0N
4	1KXT
5	P02873

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Only interaction residues

#binding
partners

	4
	3
	2
	1
	0

Sequence information

QYAPQTQSGR

TDIVHLFEWR

WVDIALECER

YLGPKGFGGV

QVSPPNENVV

VTNPSRPWWE

RYQPVSYKLC

TRSGNENEFR

DMVTRCNNVG

VRIYVDAVIN

100

101

HMCGSGAAAG

TGTTCGSYCN

PGSREFPAVP

YSAWDFNDGK

CKTASGGIES

150

151

YNDPYQVRDC

QLVGLLDLAL

EKDYVRSMIA

DYLNKLIDIG

VAGFRLDASK

200

201

HMWPGDIKAV

LDKLHNLNTN

WFPAGSRPFI

FQEVIDLGGE

AISSSEYFGN

250

251

GRVTEFKYGA

KLGTVVRKWS

GEKMSYLKNW

GEGWGFMPSD

RALVFVDNHD

300

301

NQRGHGAGGS

SILTFWDARL

YKVAVGFMLA

HPYGFTRVMS

SYRWARNFVN

350

351

GEDVNDWIGP

PNNNGVIKEV

TINADTTCGN

DWVCEHRWRE

IRNMVWFRNV

400

401

VDGQPFANWW

DNGSNQVAFG

RGNRGFIVFN

NDDWQLSSTL

QTGLPGGTYC

450

451

NVISGDKVGN

SCTGIKVYVS

SDGTAQFSIS

NSAQDPFIAI

HAESKL

500

Variants

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
4_PRO	SER	8.3kJPN chr1:104160117 rs777629405	-	0.0001	-	-
10_ARG	TRP	gnomAD chr1:104114297 rs146354476	-	0.000104112	-	-
10_ARG	GLN	gnomAD chr1:104114298 rs139632093	-	0.000992341	-	-
10_ARG	TRP	gnomAD chr1:104160135 rs145483775	-	0.000120228	-	-
20_ARG	TER	8.3kJPN chr1:104114327 rs761465185	-	0.0001	-	-
20_ARG	GLN	8.3kJPN chr1:104160166 -	-	0.0002	-	-
22_VAL	GLY	8.3kJPN chr1:104114334 -	-	0.0001	-	-
23_ASP	ASN	8.3kJPN chr1:104160174 rs754651162	-	0.0001	-	-
27_GLU	GLN	8.3kJPN chr1:104114348 -	-	0.0001	-	-
30_ARG	GLN	8.3kJPN chr1:104114358 rs558718174	-	0.0002	-	-
30_ARG	GLN	8.3kJPN chr1:104160196 rs148507365	-	0.0001	-	-
30_ARG	TER	8.3kJPN chr1:104293224 rs1350376061	-	0.0001	-	-
31_TYR	CYS	8.3kJPN chr1:104160199 -	-	0.0001	-	-
33_ALA	THR	8.3kJPN chr1:104160204 rs79714993	-	0.0001	-	-
34_PRO	THR	gnomAD chr1:104160207 rs147709536	-	0.000144051	-	-
34_PRO	ALA	gnomAD chr1:104160207 rs147709536	-	0.000332117	-	-
35_LYS	GLN	8.3kJPN chr1:104160210 rs773791633	-	0.0002	-	-
41_GLN	HIS	8.3kJPN chr1:104114392 -	-	0.0001	-	-
43_SER	PRO	gnomAD chr1:104114735 rs746610299	-	0.000107593	-	-
50_ALA	THR	gnomAD chr1:104160600 rs565929673	-	0.000184038	-	-
52_TYR	HIS	gnomAD chr1:104160606 rs772378904	-	0.000132051	-	-
52_HIS	TYR	8.3kJPN chr1:104114762 rs763891745	-	0.0001	-	-
59_TRP	TER	8.3kJPN chr1:104114784 -	-	0.0001	-	-
60_GLU	TER	8.3kJPN chr1:104114786 -	-	0.0001	-	-
64_PRO	ARG	8.3kJPN chr1:104114799 rs758698996	-	0.0001	-	-
69_LEU	PHE	8.3kJPN chr1:104114815 rs1226144068	-	0.0001	-	-
70_CYS	ARG	8.3kJPN chr1:104114816 -	-	0.0001	-	-
80_ARG	SER	gnomAD chr1:104160692 rs201971373	-	0.000337027	-	-
80_ARG	SER	8.3kJPN chr1:104160692 rs201971373	-	0.0096	-	-
84_THR	ASN	gnomAD chr1:104160703 rs143462563	-	0.00274138	-	-
84_THR	ASN	8.3kJPN chr1:104160703 rs143462563	-	0.0016	-	-
89_VAL	ILE	8.3kJPN chr1:104114873 rs766776510	-	0.0004	-	-
92_ARG	HIS	gnomAD chr1:104161537 rs543952790	-	0.000243595	-	-
92_ARG	CYS	8.3kJPN chr1:104115688 rs750106406	-	0.0001	-	-
92_ARG	CYS	8.3kJPN chr1:104161536 rs770671951	-	0.0002	-	-
97_ALA	THR	8.3kJPN chr1:104115703 rs528267080	-	-	-	-
103_SER	CYS	8.3kJPN chr1:104115722 rs4098273	-	0.0001	-	-
103_CYS	SER	8.3kJPN chr1:104161570 rs1327917758	-	0.0001	-	-
105_ASN	ILE	8.3kJPN chr1:104161576 -	-	0.0001	-	-
107_VAL	MET	8.3kJPN chr1:104115733 -	-	0.0001	-	-
108_SER	ARG	8.3kJPN chr1:104161586 rs1390018344	-	0.0001	-	-
109_ALA	SER	8.3kJPN chr1:104115739 -	-	0.0001	-	-
113_SER	ILE	8.3kJPN chr1:104161600 -	-	0.0001	-	-
123_SER	ILE	8.3kJPN chr1:104115782 -	-	0.0001	-	-
123_SER	ASN	8.3kJPN chr1:104161630 rs560183547	-	0.0007	-	-
130_PRO	SER	gnomAD chr1:104161650 rs200536753	-	0.00689471	-	-
148_ILE	VAL	8.3kJPN chr1:104161704 rs1319186352	-	0.0001	-	-
157_VAL	PHE	8.3kJPN chr1:104162176 rs1276826607	-	0.0001	-	-
159_ASP	TYR	8.3kJPN chr1:104162182 -	-	0.0001	-	-
159_ASP	GLU	8.3kJPN chr1:104162184 rs748793710	-	0.0048	-	-
161_ARG	HIS	gnomAD chr1:104116343 rs144281226	-	0.000119487	-	-
161_ARG	HIS	gnomAD chr1:104162189 rs200283230	-	0.000225717	-	-
161_ARG	HIS	8.3kJPN chr1:104162189 rs200283230	-	0.0001	-	-
163_THR	SER	gnomAD chr1:104162194 rs1143394	-	0.0152673	-	-
166_LEU	PRO	8.3kJPN chr1:104116358 rs1439427166	-	0.0001	-	-
173_ASP	VAL	8.3kJPN chr1:104162225 -	-	0.0001	-	-
174_TYR	HIS	gnomAD chr1:104116381 rs201095914	-	0.000613209	-	-
176_ARG	HIS	gnomAD chr1:104116388 rs370144544	-	0.000103535	-	-
176_ARG	HIS	gnomAD chr1:104162234 rs764700031	-	0.000194656	-	-
176_ARG	HIS	8.3kJPN chr1:104116388 rs370144544	-	0.0001	-	-
176_ARG	CYS	8.3kJPN chr1:104162233 rs763068700	-	0.0002	-	-
176_ARG	HIS	8.3kJPN chr1:104162234 rs764700031	-	0.0001	-	-
178_LYS	MET	gnomAD chr1:104162240 rs559702141	-	0.00100575	-	-
179_ILE	MET	gnomAD chr1:104116398 rs770310222	-	0.000131403	-	-
181_GLU	LYS	gnomAD chr1:104116402 rs200162760	-	0.000211041	-	-
182_TYR	HIS	8.3kJPN chr1:104116405 rs1248882715	-	0.0001	-	-
186_LEU	PHE	gnomAD chr1:104162263 rs546094070	-	0.000120942	-	-
186_LEU	VAL	8.3kJPN chr1:104162263 rs546094070	-	0.0001	-	-
189_ILE	THR	8.3kJPN chr1:104162273 rs1247561853	-	0.0001	-	-
190_GLY	SER	gnomAD chr1:104162275 rs149883399	-	0.00203761	-	-
191_VAL	ALA	8.3kJPN chr1:104162279 -	-	0.0002	-	-
195_ARG	GLY	gnomAD chr1:104162290 rs531383627	-	0.000171412	-	-
196_LEU	ILE	8.3kJPN chr1:104162293 rs549614263	-	0.0001	-	-
201_HIS	LEU	8.3kJPN chr1:104162309 rs200197467	-	0.0011	-	-
203_TRP	ARG	gnomAD chr1:104162314 rs762269432	-	0.000186309	-	-
208_LYS	GLN	8.3kJPN chr1:104116483 -	-	0.0003	-	-
215_HIS	ARG	gnomAD chr1:104162351 rs140204075	-	0.0146323	-	-
217_LEU	VAL	8.3kJPN chr1:104162356 -	-	0.0001	-	-
222_PHE	TYR	8.3kJPN chr1:104116526 -	-	0.0001	-	-
228_PRO	HIS	gnomAD chr1:104116544 rs137860562	-	0.00033871	-	-
231_TYR	PHE	8.3kJPN chr1:104116553 -	-	0.0001	-	-
238_GLY	SER	gnomAD chr1:104163185 rs142529431	-	0.000415795	-	-
238_GLY	VAL	8.3kJPN chr1:104163186 rs532919677	-	0.0005	-	-
244_SER	ASN	8.3kJPN chr1:104116913 -	-	0.0001	-	-
248_PHE	LEU	8.3kJPN chr1:104163217 -	-	0.0001	-	-
263_GLY	SER	8.3kJPN chr1:104116969 rs764566458	-	0.0001	-	-
263_GLY	SER	8.3kJPN chr1:104163260 rs746422923	-	0.0001	-	-
265_VAL	ILE	8.3kJPN chr1:104163266 rs61814453	-	0.113	-	-
267_ARG	HIS	gnomAD chr1:104163273 rs200554552	-	0.00151533	-	-
267_ARG	CYS	8.3kJPN chr1:104116981 rs368462934	-	0.0001	-	-
267_ARG	HIS	8.3kJPN chr1:104163273 rs200554552	-	0.03	-	-
268_LYS	GLU	8.3kJPN chr1:104163275 -	-	0.0002	-	-
270_ASN	SER	8.3kJPN chr1:104116991 rs752838004	-	0.0001	-	-
274_MET	ILE	gnomAD chr1:104117004 rs147458656	-	0.00025118	-	-
278_LYS	GLU	8.3kJPN chr1:104117014 -	-	0.0001	-	-
281_GLY	ARG	gnomAD chr1:104117852 rs147215616	-	0.00219045	-	-
281_GLY	GLU	gnomAD chr1:104117853 rs544350905	-	0.000211073	-	-
282_GLU	LYS	gnomAD chr1:104117855 rs755587777	-	0.000103545	-	-
285_GLY	SER	gnomAD chr1:104234213 rs748941669	-	0.000144774	-	-
287_MET	THR	8.3kJPN chr1:104117871 -	-	0.0001	-	-
288_PRO	LEU	8.3kJPN chr1:104203011 rs779901818	-	0.0001	-	-
289_SER	CYS	8.3kJPN chr1:104234200 -	-	0.0001	-	-
292_ALA	VAL	gnomAD chr1:104203023 rs201288184	-	0.00236711	-	-
292_ALA	VAL	gnomAD chr1:104234191 rs201627077	-	0.0018816	-	-
292_ALA	VAL	gnomAD chr1:104297162 rs201967863	-	0.000102512	-	-
292_ALA	VAL	8.3kJPN chr1:104234191 rs201627077	-	0.0161	-	-
292_ALA	VAL	8.3kJPN chr1:104297162 rs201967863	-	0.0001	-	-
293_LEU	PHE	8.3kJPN chr1:104234189 rs757768134	-	0.0007	-	-
294_VAL	ALA	gnomAD chr1:104117892 rs140209167	-	0.0023334	-	-
296_VAL	GLU	gnomAD chr1:104234179 rs549527747	-	0.00112844	-	-
297_ASP	TYR	8.3kJPN chr1:104117900 rs1329718469	-	0.0001	-	-
297_ASP	ASN	8.3kJPN chr1:104234177 -	-	0.0001	-	-
298_ASN	ILE	gnomAD chr1:104203041 rs150405191	-	0.000513367	-	-
300_ASP	GLU	8.3kJPN chr1:104234166 -	-	0.0001	-	-
300_ASP	VAL	8.3kJPN chr1:104234167 -	-	0.0001	-	-
301_ASN	SER	8.3kJPN chr1:104234164 rs763143822	-	0.0003	-	-
303_ARG	TER	8.3kJPN chr1:104203055 rs367719363	-	0.0001	-	-
303_ARG	TER	8.3kJPN chr1:104297194 rs752371105	-	0.0011	-	-
304_GLY	ARG	gnomAD chr1:104117921 rs140978983	-	0.0233147	-	-
306_GLY	ALA	gnomAD chr1:104297204 rs779977255	-	0.000110009	-	-
306_GLY	TRP	8.3kJPN chr1:104117927 rs1263496927	-	0.0004	-	-
307_ALA	THR	gnomAD chr1:104234147 rs140294416	-	0.000532077	-	-
307_ALA	THR	gnomAD chr1:104297206 rs139911862	-	0.000276823	-	-
307_ALA	THR	8.3kJPN chr1:104203067 rs755582791	-	0.0008	-	-
307_ALA	THR	8.3kJPN chr1:104234147 rs140294416	-	0.0001	-	-
309_GLY	GLU	8.3kJPN chr1:104297213 rs775987541	-	0.0005	-	-
310_ALA	VAL	gnomAD chr1:104234137 rs545069888	-	0.000144994	-	-
310_ALA	VAL	8.3kJPN chr1:104203077 -	-	0.0001	-	-
310_ALA	VAL	8.3kJPN chr1:104234137 rs545069888	-	0.0001	-	-
311_SER	CYS	8.3kJPN chr1:104234134 -	-	0.0001	-	-
313_LEU	ILE	gnomAD chr1:104203085 rs781432273	-	0.000236269	-	-
313_LEU	ILE	gnomAD chr1:104234129 rs577689111	-	0.000110579	-	-
313_LEU	VAL	gnomAD chr1:104297224 rs145792361	-	0.00087233	-	-
313_LEU	ARG	8.3kJPN chr1:104234128 rs758357562	-	0.001	-	-
318_ALA	THR	gnomAD chr1:104297239 rs144288724	-	0.000650053	-	-
318_ALA	VAL	8.3kJPN chr1:104234113 rs765307647	-	0.0001	-	-
323_MET	ILE	8.3kJPN chr1:104297349 rs757607457	-	0.0001	-	-
327_PHE	CYS	8.3kJPN chr1:104203222 -	-	0.0001	-	-
337_ARG	TER	8.3kJPN chr1:104118115 rs760449208	-	0.0001	-	-
337_ARG	TER	8.3kJPN chr1:104233963 rs199554865	-	0.0007	-	-
337_ARG	TER	8.3kJPN chr1:104297389 rs140363602	-	0.0001	-	-
342_TYR	TER	8.3kJPN chr1:104118132 -	-	0.0001	-	-
343_ARG	HIS	gnomAD chr1:104118134 rs150608402	-	0.000210991	-	-
343_ARG	HIS	gnomAD chr1:104203270 rs747319728	-	0.00014273	-	-
343_ARG	HIS	gnomAD chr1:104297408 rs748837763	-	0.000135517	-	-
343_ARG	HIS	8.3kJPN chr1:104118134 rs150608402	-	0.0001	-	-
343_ARG	CYS	8.3kJPN chr1:104203269 -	-	0.0001	-	-
343_ARG	HIS	8.3kJPN chr1:104203270 rs747319728	-	0.0001	-	-
343_ARG	HIS	8.3kJPN chr1:104233944 rs541141393	-	0.0002	-	-
343_ARG	CYS	8.3kJPN chr1:104297407 rs779804656	-	0.0002	-	-
343_ARG	HIS	8.3kJPN chr1:104297408 rs748837763	-	0.0001	-	-
346_ARG	THR	8.3kJPN chr1:104118143 rs1171955418	-	0.0004	-	-
349_GLU	ALA	gnomAD chr1:104203288 rs554343114	-	0.000179817	-	-
349_GLU	ALA	gnomAD chr1:104233926 rs754163001	-	0.000475111	-	-
352_ASN	SER	8.3kJPN chr1:104118161 rs572909605	-	0.0001	-	-
356_ASP	GLY	gnomAD chr1:104166498 rs552900947	-	0.000122784	-	-
361_PRO	THR	8.3kJPN chr1:104166512 -	-	0.0001	-	-
367_ILE	MET	gnomAD chr1:104120156 rs181502776	-	0.000343026	-	-
367_ILE	MET	8.3kJPN chr1:104120156 rs181502776	-	0.0023	-	-
372_ILE	MET	gnomAD chr1:104166547 rs760606304	-	0.00157031	-	-
372_ILE	MET	8.3kJPN chr1:104166547 rs760606304	-	0.0173	-	-
381_ASP	GLU	8.3kJPN chr1:104166574 -	-	0.0003	-	-
382_TRP	CYS	8.3kJPN chr1:104120201 -	-	0.0003	-	-
382_TRP	CYS	8.3kJPN chr1:104166577 -	-	0.0007	-	-
387_ARG	GLY	gnomAD chr1:104166590 rs1832269	-	0.000596638	-	-
387_ARG	GLY	8.3kJPN chr1:104166590 rs1832269	-	0.0001	-	-
389_ARG	CYS	gnomAD chr1:104166596 rs777496434	-	0.000105419	-	-
389_ARG	HIS	gnomAD chr1:104166597 rs770294712	-	0.000289424	-	-
389_ARG	HIS	8.3kJPN chr1:104120221 rs753265856	-	0.0001	-	-
389_ARG	HIS	8.3kJPN chr1:104166597 rs770294712	-	0.0004	-	-
389_ARG	CYS	8.3kJPN chr1:104205387 rs1240333808	-	0.0004	-	-
391_ILE	THR	gnomAD chr1:104120227 rs151132065	-	0.0143186	-	-
391_ILE	VAL	8.3kJPN chr1:104205393 rs1178161506	-	0.0001	-	-
394_MET	ILE	8.3kJPN chr1:104120348 -	-	0.0001	-	-
398_ARG	HIS	8.3kJPN chr1:104166735 rs1274019006	-	0.0005	-	-
398_ARG	HIS	8.3kJPN chr1:104205525 rs1257528856	-	0.0002	-	-
404_GLN	HIS	gnomAD chr1:104120378 rs150269811	-	0.000529374	-	-
404_GLN	HIS	8.3kJPN chr1:104166754 -	-	0.0001	-	-
405_PRO	ALA	8.3kJPN chr1:104166755 -	-	0.0001	-	-
420_GLY	ARG	8.3kJPN chr1:104166800 -	-	0.0001	-	-
422_GLY	ARG	8.3kJPN chr1:104205596 -	-	0.0002	-	-
430_ASN	SER	gnomAD chr1:104120455 rs370179572	-	0.00064088	-	-
433_ASP	TYR	8.3kJPN chr1:104166839 rs1231626541	-	0.0001	-	-
449_TYR	ASN	8.3kJPN chr1:104206996 -	-	0.0003	-	-
469_VAL	ALA	8.3kJPN chr1:104207057 -	-	0.0004	-	-
472_ASP	ASN	gnomAD chr1:104122045 rs150795802	-	0.000199168	-	-
477_PHE	SER	gnomAD chr1:104122061 rs145989588	-	0.00023903	-	-
490_ILE	THR	8.3kJPN chr1:104207120 -	-	0.0005	-	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

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Sequence information

Binding partner information

Binding partner information

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Binding partner information

Binding partner information

Variants

Reference