PDB ID 1BVN     CHAIN P
Protein name PROTEIN (ALPHA-AMYLASE)
Uniprot Accession P00690
The number of similar proteins 17
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1BVN (CHAIN: P)
1 P01092  
2 Monomeric state
3 4X0N  
4 1KXT  
5 P02873  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   QYAPQTQSGR   TDIVHLFEWR   WVDIALECER   YLGPKGFGGV   QVSPPNENVV   50
51   VTNPSRPWWE   RYQPVSYKLC   TRSGNENEFR   DMVTRCNNVG   VRIYVDAVIN   100
101   HMCGSGAAAG   TGTTCGSYCN   PGSREFPAVP   YSAWDFNDGK   CKTASGGIES   150
151   YNDPYQVRDC   QLVGLLDLAL   EKDYVRSMIA   DYLNKLIDIG   VAGFRLDASK   200
201   HMWPGDIKAV   LDKLHNLNTN   WFPAGSRPFI   FQEVIDLGGE   AISSSEYFGN   250
251   GRVTEFKYGA   KLGTVVRKWS   GEKMSYLKNW   GEGWGFMPSD   RALVFVDNHD   300
301   NQRGHGAGGS   SILTFWDARL   YKVAVGFMLA   HPYGFTRVMS   SYRWARNFVN   350
351   GEDVNDWIGP   PNNNGVIKEV   TINADTTCGN   DWVCEHRWRE   IRNMVWFRNV   400
401   VDGQPFANWW   DNGSNQVAFG   RGNRGFIVFN   NDDWQLSSTL   QTGLPGGTYC   450
451   NVISGDKVGN   SCTGIKVYVS   SDGTAQFSIS   NSAQDPFIAI   HAESKL   500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
4_PRO SER 8.3kJPN
chr1:104160117 		rs777629405
- 0.0001 -
10_ARG TRP gnomAD
chr1:104114297 		rs146354476
- 0.000104112 -
10_ARG GLN gnomAD
chr1:104114298 		rs139632093
- 0.000992341 -
10_ARG TRP gnomAD
chr1:104160135 		rs145483775
- 0.000120228 -
20_ARG TER 8.3kJPN
chr1:104114327 		rs761465185
- 0.0001 -
20_ARG GLN 8.3kJPN
chr1:104160166 		-
- 0.0002 -
22_VAL GLY 8.3kJPN
chr1:104114334 		-
- 0.0001 -
23_ASP ASN 8.3kJPN
chr1:104160174 		rs754651162
- 0.0001 -
27_GLU GLN 8.3kJPN
chr1:104114348 		-
- 0.0001 -
30_ARG GLN 8.3kJPN
chr1:104114358 		rs558718174
- 0.0002 -
30_ARG GLN 8.3kJPN
chr1:104160196 		rs148507365
- 0.0001 -
30_ARG TER 8.3kJPN
chr1:104293224 		rs1350376061
- 0.0001 -
31_TYR CYS 8.3kJPN
chr1:104160199 		-
- 0.0001 -
33_ALA THR 8.3kJPN
chr1:104160204 		rs79714993
- 0.0001 -
34_PRO THR gnomAD
chr1:104160207 		rs147709536
- 0.000144051 -
34_PRO ALA gnomAD
chr1:104160207 		rs147709536
- 0.000332117 -
35_LYS GLN 8.3kJPN
chr1:104160210 		rs773791633
- 0.0002 -
41_GLN HIS 8.3kJPN
chr1:104114392 		-
- 0.0001 -
43_SER PRO gnomAD
chr1:104114735 		rs746610299
- 0.000107593 -
50_ALA THR gnomAD
chr1:104160600 		rs565929673
- 0.000184038 -
52_TYR HIS gnomAD
chr1:104160606 		rs772378904
- 0.000132051 -
52_HIS TYR 8.3kJPN
chr1:104114762 		rs763891745
- 0.0001 -
59_TRP TER 8.3kJPN
chr1:104114784 		-
- 0.0001 -
60_GLU TER 8.3kJPN
chr1:104114786 		-
- 0.0001 -
64_PRO ARG 8.3kJPN
chr1:104114799 		rs758698996
- 0.0001 -
69_LEU PHE 8.3kJPN
chr1:104114815 		rs1226144068
- 0.0001 -
70_CYS ARG 8.3kJPN
chr1:104114816 		-
- 0.0001 -
80_ARG SER gnomAD
chr1:104160692 		rs201971373
- 0.000337027 -
80_ARG SER 8.3kJPN
chr1:104160692 		rs201971373
- 0.0096 -
84_THR ASN gnomAD
chr1:104160703 		rs143462563
- 0.00274138 -
84_THR ASN 8.3kJPN
chr1:104160703 		rs143462563
- 0.0016 -
89_VAL ILE 8.3kJPN
chr1:104114873 		rs766776510
- 0.0004 -
92_ARG HIS gnomAD
chr1:104161537 		rs543952790
- 0.000243595 -
92_ARG CYS 8.3kJPN
chr1:104115688 		rs750106406
- 0.0001 -
92_ARG CYS 8.3kJPN
chr1:104161536 		rs770671951
- 0.0002 -
97_ALA THR 8.3kJPN
chr1:104115703 		rs528267080
- - -
103_SER CYS 8.3kJPN
chr1:104115722 		rs4098273
- 0.0001 -
103_CYS SER 8.3kJPN
chr1:104161570 		rs1327917758
- 0.0001 -
105_ASN ILE 8.3kJPN
chr1:104161576 		-
- 0.0001 -
107_VAL MET 8.3kJPN
chr1:104115733 		-
- 0.0001 -
108_SER ARG 8.3kJPN
chr1:104161586 		rs1390018344
- 0.0001 -
109_ALA SER 8.3kJPN
chr1:104115739 		-
- 0.0001 -
113_SER ILE 8.3kJPN
chr1:104161600 		-
- 0.0001 -
123_SER ILE 8.3kJPN
chr1:104115782 		-
- 0.0001 -
123_SER ASN 8.3kJPN
chr1:104161630 		rs560183547
- 0.0007 -
130_PRO SER gnomAD
chr1:104161650 		rs200536753
- 0.00689471 -
148_ILE VAL 8.3kJPN
chr1:104161704 		rs1319186352
- 0.0001 -
157_VAL PHE 8.3kJPN
chr1:104162176 		rs1276826607
- 0.0001 -
159_ASP TYR 8.3kJPN
chr1:104162182 		-
- 0.0001 -
159_ASP GLU 8.3kJPN
chr1:104162184 		rs748793710
- 0.0048 -
161_ARG HIS gnomAD
chr1:104116343 		rs144281226
- 0.000119487 -
161_ARG HIS gnomAD
chr1:104162189 		rs200283230
- 0.000225717 -
161_ARG HIS 8.3kJPN
chr1:104162189 		rs200283230
- 0.0001 -
163_THR SER gnomAD
chr1:104162194 		rs1143394
- 0.0152673 -
166_LEU PRO 8.3kJPN
chr1:104116358 		rs1439427166
- 0.0001 -
173_ASP VAL 8.3kJPN
chr1:104162225 		-
- 0.0001 -
174_TYR HIS gnomAD
chr1:104116381 		rs201095914
- 0.000613209 -
176_ARG HIS gnomAD
chr1:104116388 		rs370144544
- 0.000103535 -
176_ARG HIS gnomAD
chr1:104162234 		rs764700031
- 0.000194656 -
176_ARG HIS 8.3kJPN
chr1:104116388 		rs370144544
- 0.0001 -
176_ARG CYS 8.3kJPN
chr1:104162233 		rs763068700
- 0.0002 -
176_ARG HIS 8.3kJPN
chr1:104162234 		rs764700031
- 0.0001 -
178_LYS MET gnomAD
chr1:104162240 		rs559702141
- 0.00100575 -
179_ILE MET gnomAD
chr1:104116398 		rs770310222
- 0.000131403 -
181_GLU LYS gnomAD
chr1:104116402 		rs200162760
- 0.000211041 -
182_TYR HIS 8.3kJPN
chr1:104116405 		rs1248882715
- 0.0001 -
186_LEU PHE gnomAD
chr1:104162263 		rs546094070
- 0.000120942 -
186_LEU VAL 8.3kJPN
chr1:104162263 		rs546094070
- 0.0001 -
189_ILE THR 8.3kJPN
chr1:104162273 		rs1247561853
- 0.0001 -
190_GLY SER gnomAD
chr1:104162275 		rs149883399
- 0.00203761 -
191_VAL ALA 8.3kJPN
chr1:104162279 		-
- 0.0002 -
195_ARG GLY gnomAD
chr1:104162290 		rs531383627
- 0.000171412 -
196_LEU ILE 8.3kJPN
chr1:104162293 		rs549614263
- 0.0001 -
201_HIS LEU 8.3kJPN
chr1:104162309 		rs200197467
- 0.0011 -
203_TRP ARG gnomAD
chr1:104162314 		rs762269432
- 0.000186309 -
208_LYS GLN 8.3kJPN
chr1:104116483 		-
- 0.0003 -
215_HIS ARG gnomAD
chr1:104162351 		rs140204075
- 0.0146323 -
217_LEU VAL 8.3kJPN
chr1:104162356 		-
- 0.0001 -
222_PHE TYR 8.3kJPN
chr1:104116526 		-
- 0.0001 -
228_PRO HIS gnomAD
chr1:104116544 		rs137860562
- 0.00033871 -
231_TYR PHE 8.3kJPN
chr1:104116553 		-
- 0.0001 -
238_GLY SER gnomAD
chr1:104163185 		rs142529431
- 0.000415795 -
238_GLY VAL 8.3kJPN
chr1:104163186 		rs532919677
- 0.0005 -
244_SER ASN 8.3kJPN
chr1:104116913 		-
- 0.0001 -
248_PHE LEU 8.3kJPN
chr1:104163217 		-
- 0.0001 -
263_GLY SER 8.3kJPN
chr1:104116969 		rs764566458
- 0.0001 -
263_GLY SER 8.3kJPN
chr1:104163260 		rs746422923
- 0.0001 -
265_VAL ILE 8.3kJPN
chr1:104163266 		rs61814453
- 0.113 -
267_ARG HIS gnomAD
chr1:104163273 		rs200554552
- 0.00151533 -
267_ARG CYS 8.3kJPN
chr1:104116981 		rs368462934
- 0.0001 -
267_ARG HIS 8.3kJPN
chr1:104163273 		rs200554552
- 0.03 -
268_LYS GLU 8.3kJPN
chr1:104163275 		-
- 0.0002 -
270_ASN SER 8.3kJPN
chr1:104116991 		rs752838004
- 0.0001 -
274_MET ILE gnomAD
chr1:104117004 		rs147458656
- 0.00025118 -
278_LYS GLU 8.3kJPN
chr1:104117014 		-
- 0.0001 -
281_GLY ARG gnomAD
chr1:104117852 		rs147215616
- 0.00219045 -
281_GLY GLU gnomAD
chr1:104117853 		rs544350905
- 0.000211073 -
282_GLU LYS gnomAD
chr1:104117855 		rs755587777
- 0.000103545 -
285_GLY SER gnomAD
chr1:104234213 		rs748941669
- 0.000144774 -
287_MET THR 8.3kJPN
chr1:104117871 		-
- 0.0001 -
288_PRO LEU 8.3kJPN
chr1:104203011 		rs779901818
- 0.0001 -
289_SER CYS 8.3kJPN
chr1:104234200 		-
- 0.0001 -
292_ALA VAL gnomAD
chr1:104203023 		rs201288184
- 0.00236711 -
292_ALA VAL gnomAD
chr1:104234191 		rs201627077
- 0.0018816 -
292_ALA VAL gnomAD
chr1:104297162 		rs201967863
- 0.000102512 -
292_ALA VAL 8.3kJPN
chr1:104234191 		rs201627077
- 0.0161 -
292_ALA VAL 8.3kJPN
chr1:104297162 		rs201967863
- 0.0001 -
293_LEU PHE 8.3kJPN
chr1:104234189 		rs757768134
- 0.0007 -
294_VAL ALA gnomAD
chr1:104117892 		rs140209167
- 0.0023334 -
296_VAL GLU gnomAD
chr1:104234179 		rs549527747
- 0.00112844 -
297_ASP TYR 8.3kJPN
chr1:104117900 		rs1329718469
- 0.0001 -
297_ASP ASN 8.3kJPN
chr1:104234177 		-
- 0.0001 -
298_ASN ILE gnomAD
chr1:104203041 		rs150405191
- 0.000513367 -
300_ASP GLU 8.3kJPN
chr1:104234166 		-
- 0.0001 -
300_ASP VAL 8.3kJPN
chr1:104234167 		-
- 0.0001 -
301_ASN SER 8.3kJPN
chr1:104234164 		rs763143822
- 0.0003 -
303_ARG TER 8.3kJPN
chr1:104203055 		rs367719363
- 0.0001 -
303_ARG TER 8.3kJPN
chr1:104297194 		rs752371105
- 0.0011 -
304_GLY ARG gnomAD
chr1:104117921 		rs140978983
- 0.0233147 -
306_GLY ALA gnomAD
chr1:104297204 		rs779977255
- 0.000110009 -
306_GLY TRP 8.3kJPN
chr1:104117927 		rs1263496927
- 0.0004 -
307_ALA THR gnomAD
chr1:104234147 		rs140294416
- 0.000532077 -
307_ALA THR gnomAD
chr1:104297206 		rs139911862
- 0.000276823 -
307_ALA THR 8.3kJPN
chr1:104203067 		rs755582791
- 0.0008 -
307_ALA THR 8.3kJPN
chr1:104234147 		rs140294416
- 0.0001 -
309_GLY GLU 8.3kJPN
chr1:104297213 		rs775987541
- 0.0005 -
310_ALA VAL gnomAD
chr1:104234137 		rs545069888
- 0.000144994 -
310_ALA VAL 8.3kJPN
chr1:104203077 		-
- 0.0001 -
310_ALA VAL 8.3kJPN
chr1:104234137 		rs545069888
- 0.0001 -
311_SER CYS 8.3kJPN
chr1:104234134 		-
- 0.0001 -
313_LEU ILE gnomAD
chr1:104203085 		rs781432273
- 0.000236269 -
313_LEU ILE gnomAD
chr1:104234129 		rs577689111
- 0.000110579 -
313_LEU VAL gnomAD
chr1:104297224 		rs145792361
- 0.00087233 -
313_LEU ARG 8.3kJPN
chr1:104234128 		rs758357562
- 0.001 -
318_ALA THR gnomAD
chr1:104297239 		rs144288724
- 0.000650053 -
318_ALA VAL 8.3kJPN
chr1:104234113 		rs765307647
- 0.0001 -
323_MET ILE 8.3kJPN
chr1:104297349 		rs757607457
- 0.0001 -
327_PHE CYS 8.3kJPN
chr1:104203222 		-
- 0.0001 -
337_ARG TER 8.3kJPN
chr1:104118115 		rs760449208
- 0.0001 -
337_ARG TER 8.3kJPN
chr1:104233963 		rs199554865
- 0.0007 -
337_ARG TER 8.3kJPN
chr1:104297389 		rs140363602
- 0.0001 -
342_TYR TER 8.3kJPN
chr1:104118132 		-
- 0.0001 -
343_ARG HIS gnomAD
chr1:104118134 		rs150608402
- 0.000210991 -
343_ARG HIS gnomAD
chr1:104203270 		rs747319728
- 0.00014273 -
343_ARG HIS gnomAD
chr1:104297408 		rs748837763
- 0.000135517 -
343_ARG HIS 8.3kJPN
chr1:104118134 		rs150608402
- 0.0001 -
343_ARG CYS 8.3kJPN
chr1:104203269 		-
- 0.0001 -
343_ARG HIS 8.3kJPN
chr1:104203270 		rs747319728
- 0.0001 -
343_ARG HIS 8.3kJPN
chr1:104233944 		rs541141393
- 0.0002 -
343_ARG CYS 8.3kJPN
chr1:104297407 		rs779804656
- 0.0002 -
343_ARG HIS 8.3kJPN
chr1:104297408 		rs748837763
- 0.0001 -
346_ARG THR 8.3kJPN
chr1:104118143 		rs1171955418
- 0.0004 -
349_GLU ALA gnomAD
chr1:104203288 		rs554343114
- 0.000179817 -
349_GLU ALA gnomAD
chr1:104233926 		rs754163001
- 0.000475111 -
352_ASN SER 8.3kJPN
chr1:104118161 		rs572909605
- 0.0001 -
356_ASP GLY gnomAD
chr1:104166498 		rs552900947
- 0.000122784 -
361_PRO THR 8.3kJPN
chr1:104166512 		-
- 0.0001 -
367_ILE MET gnomAD
chr1:104120156 		rs181502776
- 0.000343026 -
367_ILE MET 8.3kJPN
chr1:104120156 		rs181502776
- 0.0023 -
372_ILE MET gnomAD
chr1:104166547 		rs760606304
- 0.00157031 -
372_ILE MET 8.3kJPN
chr1:104166547 		rs760606304
- 0.0173 -
381_ASP GLU 8.3kJPN
chr1:104166574 		-
- 0.0003 -
382_TRP CYS 8.3kJPN
chr1:104120201 		-
- 0.0003 -
382_TRP CYS 8.3kJPN
chr1:104166577 		-
- 0.0007 -
387_ARG GLY gnomAD
chr1:104166590 		rs1832269
- 0.000596638 -
387_ARG GLY 8.3kJPN
chr1:104166590 		rs1832269
- 0.0001 -
389_ARG CYS gnomAD
chr1:104166596 		rs777496434
- 0.000105419 -
389_ARG HIS gnomAD
chr1:104166597 		rs770294712
- 0.000289424 -
389_ARG HIS 8.3kJPN
chr1:104120221 		rs753265856
- 0.0001 -
389_ARG HIS 8.3kJPN
chr1:104166597 		rs770294712
- 0.0004 -
389_ARG CYS 8.3kJPN
chr1:104205387 		rs1240333808
- 0.0004 -
391_ILE THR gnomAD
chr1:104120227 		rs151132065
- 0.0143186 -
391_ILE VAL 8.3kJPN
chr1:104205393 		rs1178161506
- 0.0001 -
394_MET ILE 8.3kJPN
chr1:104120348 		-
- 0.0001 -
398_ARG HIS 8.3kJPN
chr1:104166735 		rs1274019006
- 0.0005 -
398_ARG HIS 8.3kJPN
chr1:104205525 		rs1257528856
- 0.0002 -
404_GLN HIS gnomAD
chr1:104120378 		rs150269811
- 0.000529374 -
404_GLN HIS 8.3kJPN
chr1:104166754 		-
- 0.0001 -
405_PRO ALA 8.3kJPN
chr1:104166755 		-
- 0.0001 -
420_GLY ARG 8.3kJPN
chr1:104166800 		-
- 0.0001 -
422_GLY ARG 8.3kJPN
chr1:104205596 		-
- 0.0002 -
430_ASN SER gnomAD
chr1:104120455 		rs370179572
- 0.00064088 -
433_ASP TYR 8.3kJPN
chr1:104166839 		rs1231626541
- 0.0001 -
449_TYR ASN 8.3kJPN
chr1:104206996 		-
- 0.0003 -
469_VAL ALA 8.3kJPN
chr1:104207057 		-
- 0.0004 -
472_ASP ASN gnomAD
chr1:104122045 		rs150795802
- 0.000199168 -
477_PHE SER gnomAD
chr1:104122061 		rs145989588
- 0.00023903 -
490_ILE THR 8.3kJPN
chr1:104207120 		-
- 0.0005 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.