PDB ID 2BP5     CHAIN M
Protein name CLATHRIN COAT ASSEMBLY PROTEIN AP50
Uniprot Accession P84092
The number of similar proteins 16
The number of binding states 7
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2BP5 (CHAIN: M)
1 Monomeric state
2 P63010  
3 P63010   Q66HM2  
4 P62743   P18484  
5 P62743   P63010   P17427  
6 P84092   P62743   P63010   Q66HM2  
7 P62743   P63010   P18484   Q0JRZ9  

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Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   MIGGLFIYNH   KGEVLISRVY   RDDIGRNAVD   AFRVNVIHAR   QQVRSPVTNI   50
51   ARTSFFHVKR   SNIWLAAVTK   QNVNAAMVFE   FLYKMCDVMA   AYFGKISEEN   100
101   IKNNFVLIYE   LLDEILDFGY   PQNSETGALK   TFITQQGIKS   QHQTKEEQSQ   150
151   ITSQVTGQIG   WRREGIKYRR   NELFLDVLES   VNLLMSPQGQ   VLSAHVSGRV   200
201   VMKSYLSGMP   ECKFGMNDKI   VIEKQGKGTA   DETSKSGKQS   IAIDDCTFHQ   250
251   CVRLSKFDSE   RSISFIPPDG   EFELMRYRTT   KDIILPFRVI   PLVREVGRTK   300
301   LEVKVVIKSN   FKPSLLAQKI   EVRIPTPLNT   SGVQVICMKG   KAKYKASENA   350
351   IVWKIKRMAG   MKESQISAEI   ELLPTNDKKK   WARPPISMNF   EVPFAPSGLK   400
401   VRYLKVFEPK   LNYSDHDVIK   WVRYIGRSGI   YETRC     450

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
170_ARG TRP ClinVar
chr3:183898715
rs1577059692
Pathogenic/Likely pathogenic - - not provided|Intellectual developmental disorder 60 with seizures|Seizure [MedGen:C3661900|MONDO:MONDO:0032823,MedGen:C5231497,OMIM:618587|Human Phenotype Ontology:HP:0001250,Human Phenotype Ontology:HP:0001275,Human Phenotype Ontology:HP:0001303,Human Phenotype Ontology:HP:0002125,Human Phenotype Ontology:HP:0002182,Human Phenotype Ontology:HP:0002279,Human Phenotype Ontology:HP:0002306,Human Phenotype Ontology:HP:0002348,Human Phenotype Ontology:HP:0002391,Human Phenotype Ontology:HP:0002417,Human Phenotype Ontology:HP:0002430,Human Phenotype Ontology:HP:0002431,Human Phenotype Ontology:HP:0002432,Human Phenotype Ontology:HP:0002434,Human Phenotype Ontology:HP:0002437,Human Phenotype Ontology:HP:0002466,Human Phenotype Ontology:HP:0002479,Human Phenotype Ontology:HP:0002794,Human Phenotype Ontology:HP:0006997,Human Phenotype Ontology:HP:0010520,MedGen:C0036572]; Autism [Human Phenotype Ontology:HP:0000717,MONDO:MONDO:0005260,MedGen:C0004352,OMIM:209850]; Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]
313_PRO ALA 8.3kJPN
chr3:183899809
rs1360424786
- 0.0002 - -
335_VAL ALA 8.3kJPN
chr3:183899979
-
- 0.0001 - -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

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