PDB ID 2VXT     CHAIN I
Protein name INTERLEUKIN-18
Uniprot Accession Q14116
The number of similar proteins 16
The number of binding states 7
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2VXT (CHAIN: I)
1 2VXT   2VXT  
2 Monomeric state
3 Q13478  
4 Q9IW12  
5 Q9DHU8  
6 Q13478   O95256  
7 P49662   P49662  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   YFGKLESKLS   VIRNLNDQVL   FIDQGNRPLF   EDMTDSDARD   NAPRTIFIIS   50
51   MYKDSQPRGM   AVTISVKAEK   ISTLSAENKI   ISFKEMNPPD   NIKDTKSDII   100
101   FFQRSVPGHD   NKMQFESSSY   EGYFLAAEKE   RDLFKLILKK   EDELGDRSIM   150
151   FTVQNED           200

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
47_VAL ILE gnomAD
chr11:112020882
rs567330603
- 0.000153539 0.0662 -
71_ASP GLY 8.3kJPN
chr11:112020809
-
- 0.0001 0.5993 -
76_ASP GLY 8.3kJPN
chr11:112019459
-
- 0.0001 0.0852 -
80_ARG GLN 8.3kJPN
chr11:112019447
rs768843343
- 0.0001 0.0715 -
129_LYS ASN 8.3kJPN
chr11:112014514
-
- 0.0001 0.0915 -
167_ARG LYS 8.3kJPN
chr11:112014401
rs199644300
- 0.0001 0.0651 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.