PDB ID 3S4S     CHAIN G
Protein name T-cell surface glycoprotein CD4
Uniprot Accession P01730
The number of similar proteins 39
The number of binding states 8
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3S4S (CHAIN: G)
1 P04229   P01903  
2 Monomeric state
3 5CAY  
4 8W90  
5 3O2D   3O2D  
6 P06343   P01910  
7 2B4C   1465781  
8 3LQA   Q1PHM6   3LQA  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   DLGSKKVVLG   KKGDTVELTC   TASQKKSIQF   HWKNSNQIKI   LGNYGSFLWK   50
51   GPSKLNDRAD   SRRSLWDQGN   FPLIIKNLKI   EDSDTYICEV   EDQKEEVQLL   100
101   VFGLTANSDT   HLLQGQSLTL   TLESPPGSSP   SVQCRSPRGK   NIQGGKTLSV   150
151   SQLELQDSGT   WTCTVLQNQK   KVEFKIDIVV   LAAAAHHHHH   H   200

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
39_ASN HIS 8.3kJPN
chr12:6909613
-
- 0.0001 0.1281 -
54_ARG HIS 8.3kJPN
chr12:6923329
-
- 0.0001 0.4531 -
55_ALA THR 8.3kJPN
chr12:6923331
rs201343243
- 0.0007 0.1009 -
140_GLY TRP 8.3kJPN
chr12:6924044
rs371349550
- - 0.3264 -
166_LYS GLU VAR_023459
rs28917504
LB/B - 0.0652 -
166_LYS GLU gnomAD
chr12:6924122
rs28917504
- 0.00150413 0.0652 -
174_ILE PHE 8.3kJPN
chr12:6924146
rs782497073
- 0.0084 0.3696 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.