PDB ID 3W97     CHAIN D
Protein name Histone H2B type 1-J
Uniprot Accession P06899
The number of similar proteins 238
The number of binding states 21
The number of binding partners 17

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GSHMDGKKRK   RSRKESYSIY   VYKVLKQVHP   DTGISSKAMG   IMNSFVNDIF   50
51   ERIAGEASRL   AHYNKRSTIT   SREIQTAVRL   LLPGELAKHA   VSEGTKAVTK   100
101   YTSAK           150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
32_THR ILE 8.3kJPN
chr6:25727237
rs147766950
- 0.0001 - -
32_SER ARG 8.3kJPN
chr6:26184120
-
- 0.0001 0.7748 -
34_LYS ARG gnomAD
chr1:149783775
rs143086420
- 0.00139572 0.1092 -
35_GLU TER 8.3kJPN
chr6:25727245
-
- 0.0001 - -
37_TYR TER 8.3kJPN
chr6:26251992
-
- 0.0001 - -
37_TYR CYS 8.3kJPN
chr6:27100417
rs1305868682
- 0.0001 0.9679 -
38_SER CYS gnomAD
chr6:25727255
rs199691595
- 0.000107405 0.3999 -
38_SER CYS 8.3kJPN
chr6:26216756
-
- 0.0001 0.3999 -
38_SER CYS 8.3kJPN
chr6:26251994
-
- 0.0003 0.3999 -
39_VAL ALA 8.3kJPN
chr1:149783760
-
- 0.0001 - -
39_VAL LEU 8.3kJPN
chr6:27775567
rs780283212
- 0.0001 - -
41_VAL LEU 8.3kJPN
chr1:149783755
rs782143987
- 0.0001 0.8274 -
43_LYS GLU 8.3kJPN
chr1:228645960
rs1192514228
- 0.0001 0.997 -
44_VAL LEU 8.3kJPN
chr6:26252011
rs774570728
- 0.0003 0.9969 -
50_PRO LEU 8.3kJPN
chr6:25727291
rs143128181
- 0.0001 0.9677 -
50_PRO SER 8.3kJPN
chr6:26199937
rs1023705388
- 0.0001 0.9191 -
50_PRO THR 8.3kJPN
chr6:27100379
rs774667736
- 0.0002 0.9223 -
51_ASP ASN 8.3kJPN
chr6:26252032
-
- 0.0001 0.8807 -
51_ASP GLY 8.3kJPN
chr6:27782976
-
- 0.0001 0.9223 -
52_THR SER 8.3kJPN
chr6:26199944
-
- 0.0001 0.8817 -
52_THR ALA 8.3kJPN
chr6:26273360
rs1458054891
- 0.0001 0.8247 -
53_GLY ALA 8.3kJPN
chr6:26043725
-
- 0.0001 0.9562 -
53_GLY SER 8.3kJPN
chr6:26199946
-
- 0.0001 0.9592 -
53_GLY SER 8.3kJPN
chr6:27775525
-
- 0.0001 0.9592 -
54_ILE VAL 8.3kJPN
chr6:26216709
-
- 0.0001 0.2543 -
55_SER LEU 8.3kJPN
chr1:228645997
rs1353478558
- 0.0001 0.9961 -
55_SER PHE 8.3kJPN
chr6:26252045
rs750512885
- 0.0001 0.9973 -
56_SER PHE 8.3kJPN
chr6:26043716
-
- 0.0001 0.9514 -
56_SER PHE 8.3kJPN
chr6:26252048
rs1391696815
- 0.0001 0.9514 -
57_LYS MET 8.3kJPN
chr1:149783706
-
- 0.0001 0.9742 -
58_ALA VAL 8.3kJPN
chr6:26043710
-
- 0.0001 0.9962 -
59_MET ILE 8.3kJPN
chr1:228646010
rs1440295879
- 0.0001 0.9927 -
59_MET LEU 8.3kJPN
chr6:26252056
-
- 0.0001 0.9199 -
60_GLY SER 8.3kJPN
chr6:27861421
rs1410298024
- 0.0001 0.1157 -
62_MET ILE 8.3kJPN
chr6:27100341
rs1402019530
- 0.0001 0.9673 -
63_ASN SER 8.3kJPN
chr6:25727330
rs1237711095
- 0.0001 0.7132 -
66_VAL ILE gnomAD
chr6:26043687
rs566958517
- 0.000147129 0.3506 -
66_VAL ILE 8.3kJPN
chr1:149783680
rs1438376476
- 0.0001 0.3506 -
67_ASN SER 8.3kJPN
chr1:228646033
-
- 0.0001 0.1121 -
69_ILE THR gnomAD
chr6:25727348
rs761537792
- 0.000186952 0.9019 -
69_ILE VAL gnomAD
chr6:26043678
rs144272993
- 0.000111342 0.1879 -
69_ILE VAL 8.3kJPN
chr1:228646038
rs779849447
- 0.0001 0.1879 -
69_ILE VAL 8.3kJPN
chr6:25727347
rs774096146
- 0.0001 0.1879 -
70_PHE SER 8.3kJPN
chr6:25727351
rs1431133085
- 0.0001 0.996 -
72_ARG CYS 8.3kJPN
chr6:26273420
rs757772183
- 0.0001 0.9876 -
72_ARG CYS 8.3kJPN
chr6:27861457
-
- 0.0001 0.9876 -
73_ILE LEU 8.3kJPN
chr6:25727359
-
- 0.0001 0.3608 -
74_ALA PRO 8.3kJPN
chr6:27775462
-
- 0.0001 0.9987 -
75_SER ASN gnomAD
chr6:25727366
rs753295081
- 0.000107417 - -
75_SER ASN 8.3kJPN
chr6:25727366
rs753295081
- 0.0002 - -
75_GLY ASP 8.3kJPN
chr6:26273430
-
- 0.0001 0.9093 -
77_ALA VAL gnomAD
chr6:26252111
rs199520662
- 0.000139168 0.9905 -
77_ALA SER 8.3kJPN
chr1:149857959
-
- 0.0003 0.3148 -
77_ALA VAL 8.3kJPN
chr1:228646063
rs759631368
- 0.0002 0.9905 -
78_SER PRO 8.3kJPN
chr1:228646065
-
- 0.0001 0.9974 -
79_ARG LEU 8.3kJPN
chr1:228646069
rs1244127669
- 0.0001 0.9576 -
79_ARG HIS 8.3kJPN
chr6:26158636
-
- 0.0001 0.7103 -
81_ALA SER gnomAD
chr6:25727383
rs150616838
- 0.000143293 0.3817 -
81_ALA GLU 8.3kJPN
chr6:26123888
rs752759673
- 0.0001 0.9967 -
81_ALA THR 8.3kJPN
chr6:26216628
-
- 0.0001 0.6961 -
81_ALA THR 8.3kJPN
chr6:26252122
rs745564288
- 0.0019 0.6961 -
82_HIS GLN 8.3kJPN
chr6:26216623
-
- 0.0001 0.4225 -
82_HIS TYR 8.3kJPN
chr6:26252125
rs755796999
- 0.0001 0.3684 -
84_ASN SER 8.3kJPN
chr6:26252132
rs542798893
- 0.0003 0.1421 -
85_LYS ARG gnomAD
chr6:26200043
rs151100683
- 0.000421481 0.1429 -
87_SER TER 8.3kJPN
chr6:26184286
rs191131837
- 0.0033 - -
89_ILE THR gnomAD
chr6:27861509
rs148188690
- 0.000206855 0.9964 -
89_ILE VAL 8.3kJPN
chr6:27861508
-
- 0.0001 0.2477 -
92_ARG LYS gnomAD
chr6:27100252
rs116395770
- 0.000170985 0.9814 -
92_ARG GLY 8.3kJPN
chr6:26184300
-
- 0.0001 0.9965 -
92_ARG LYS 8.3kJPN
chr6:26273481
-
- 0.0001 0.9814 -
93_GLU TER 8.3kJPN
chr6:26158677
-
- 0.0001 - -
94_ILE VAL gnomAD
chr1:149857908
rs373633210
- 0.000231162 0.3109 -
94_ILE PHE 8.3kJPN
chr6:27806722
-
- 0.0001 0.9905 -
95_GLN TER 8.3kJPN
chr6:26043600
-
- 0.0001 - -
95_GLN LEU 8.3kJPN
chr6:26158684
-
- 0.0001 0.9911 -
95_GLN LEU 8.3kJPN
chr6:26184310
rs768613673
- 0.0001 0.9911 -
97_ALA THR 8.3kJPN
chr6:26043594
-
- 0.0001 0.9855 -
101_LEU MET 8.3kJPN
chr6:26043582
-
- 0.0001 0.6807 -
101_LEU VAL 8.3kJPN
chr6:26158701
-
- 0.0001 0.6174 -
107_ALA SER 8.3kJPN
chr6:27114256
-
- 0.0001 0.4462 -
107_ALA THR 8.3kJPN
chr6:27775363
-
- 0.0001 0.9955 -
110_ALA THR 8.3kJPN
chr6:27775354
-
- 0.0001 0.9975 -
119_THR SER 8.3kJPN
chr6:26200144
-
- 0.0001 0.9165 -
120_LYS ARG 8.3kJPN
chr6:26252240
rs752163332
- 0.0001 0.3726 -
122_THR SER 8.3kJPN
chr6:26043518
rs1266161609
- 0.0001 0.4544 -
123_SER ASN 8.3kJPN
chr6:26043515
rs769308092
- 0.0001 0.6908 -
124_SER PHE 8.3kJPN
chr6:25727513
rs201800096
- 0.0004 - -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.