PDB ID 1ML0     CHAIN D
Protein name Small Inducible Cytokine
Uniprot Accession P13500
The number of similar proteins 19
The number of binding states 10
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1ML0 (CHAIN: D)
1 O41925  
2 Monomeric state
3 A0A023FDY8  
4 Q2F862  
5 P13500  
6 P13500   A0A0C9S461  
7 A0A0C9S461   A0A0C9S461  
8 4DN4   4DN4  
9 O41925   O41925  
10 2BDN   2BDN  

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Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   QPDAINAAVT   CCYNFTNRKI   SVQRLASYRR   ITSSKCPKEA   VIFKTIVAKE   50
51   ICADPKQKWV   QDSIDHLDKQ   TQTPKT       100

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
13_TYR CYS 8.3kJPN
chr17:32583271
-
- 0.0001 0.4207 -
24_ARG LYS 8.3kJPN
chr17:32583304
-
- 0.0001 0.1212 -
26_ALA VAL 8.3kJPN
chr17:32583310
rs148937652
- 0.0021 0.0918 -
46_ILE VAL gnomAD
chr17:32583751
rs148285031
- 0.000131853 0.0707 -
48_ALA THR gnomAD
chr17:32583757
rs190996557
- 0.000758471 0.1214 -
48_ALA VAL 8.3kJPN
chr17:32583758
-
- 0.0002 0.2887 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.