| PDB ID | 1EFX
|
CHAIN | D |
|---|---|---|---|
| Protein name | NATURAL KILLER CELL RECEPTOR KIR2DL2 | ||
| Uniprot Accession | P43627 | ||
| The number of similar proteins | 19 | ||
| The number of binding states | 8 | ||
| The number of binding partners | 6 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1EFX (CHAIN: D) | |
| 1 |
P43627
495038
|
| 2 | Monomeric state |
| 3 |
P10321
|
| 4 |
P43627
|
| 5 |
9F2D
|
| 6 |
9LRF
9LRF
|
| 7 |
9LRH
9LRH
|
| 8 |
9HML
9HML
|
Downdload
Molecule viewer
|
Only interaction residues |
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|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 11_LEU | ARG |
gnomAD chr19:55253450 rs202032116 |
- | 0.0204467 | 0.0933 | - | |
| 11_LEU | GLN |
gnomAD chr19:55331192 rs781579173 |
- | 0.000183817 | 0.0933 | - | |
| 15_GLY | ASP |
gnomAD chr19:55284821 rs371289444 |
- | 0.00136609 | 0.1892 | - | |
| 16_ARG | PRO |
VAR_021929
rs1555897648 |
LB/B | - | 0.0508 | - | |
| 16_PRO | ARG |
gnomAD chr19:55253465 - |
- | 0.000150996 | - | - | |
| 16_ARG | PRO |
gnomAD chr19:55284824 rs35509911 |
- | 0.0958553 | 0.0508 | - | |
| 16_PRO | THR |
gnomAD chr19:55365240 rs201239422 |
- | 0.0503237 | - | - | |
| 16_ARG | PRO |
8.3kJPN chr19:55284824 rs35509911 |
- | 0.0986 | 0.0508 | - | |
| 16_PRO | THR |
8.3kJPN chr19:55365240 rs201239422 |
- | 0.1079 | - | - | |
| 18_VAL | LEU |
gnomAD chr19:55331212 rs376516392 |
- | 0.000339263 | 0.2372 | - | |
| 18_VAL | LEU |
8.3kJPN chr19:55284829 rs1371699154 |
- | 0.0004 | 0.2372 | - | |
| 21_GLY | GLU |
gnomAD chr19:55331222 rs763946257 |
- | 0.000131998 | - | - | |
| 21_GLU | GLN |
8.3kJPN chr19:55253479 rs763070147 |
- | 0.0001 | 0.0989 | - | |
| 22_GLU | ASP |
gnomAD chr19:55331226 rs201471071 |
- | 0.000323146 | 0.1677 | - | |
| 23_THR | ARG |
gnomAD chr19:55284845 rs776192485 |
- | 0.000666687 | 0.0956 | - | |
| 23_ARG | THR |
gnomAD chr19:55331228 rs2273730 |
- | 0.000973077 | - | - | |
| 23_ARG | THR |
8.3kJPN chr19:55331228 rs2273730 |
- | 0.0083 | - | - | |
| 24_VAL | LEU |
8.3kJPN chr19:55284847 - |
- | 0.0001 | 0.2912 | - | |
| 25_ILE | PHE |
gnomAD chr19:55365267 rs989801878 |
- | 0.000175855 | 0.1197 | - | |
| 27_GLN | TER |
8.3kJPN chr19:55331239 rs187691652 |
- | 0.0013 | - | - | |
| 28_CYS | ARG |
8.3kJPN chr19:55365276 - |
- | 0.0001 | 0.8732 | - | |
| 33_MET | VAL |
gnomAD chr19:55331257 rs200580859 |
- | 0.000203455 | - | - | |
| 33_ARG | MET |
8.3kJPN chr19:55253516 rs761188803 |
- | 0.0002 | 0.0639 | - | |
| 35_GLN | GLU |
gnomAD chr19:55253521 rs35719984 |
- | 0.00211406 | - | - | |
| 35_GLN | GLU |
8.3kJPN chr19:55253521 rs35719984 |
- | 0.003 | - | - | |
| 38_LEU | PHE |
8.3kJPN chr19:55253530 - |
- | 0.0001 | 0.0866 | - | |
| 41_ARG | THR |
gnomAD chr19:55253540 rs76843526 |
- | 0.00178579 | 0.1315 | - | |
| 42_GLU | ASP |
gnomAD chr19:55365320 - |
- | 0.27141 | 0.1781 | - | |
| 42_GLU | ASP |
8.3kJPN chr19:55365320 rs633870 |
- | 0.4278 | 0.1781 | - | |
| 44_MET | THR |
8.3kJPN chr19:55284908 rs200839187 |
- | 0.0001 | - | - | |
| 45_PHE | TYR |
VAR_059418
rs78713511 |
LB/B | - | 0.0611 | - | |
| 46_LYS | ASN |
gnomAD chr19:55253556 rs145638569 |
- | 0.00034299 | 0.0917 | - | |
| 46_LYS | GLU |
gnomAD chr19:55331296 rs74799106 |
- | 0.00363866 | 0.0648 | - | |
| 46_LYS | ASN |
8.3kJPN chr19:55253556 rs145638569 |
- | 0.0001 | 0.0917 | - | |
| 47_ASP | ASN |
gnomAD chr19:55253557 rs528413442 |
- | 0.000316645 | 0.1004 | - | |
| 47_ASP | ASN |
8.3kJPN chr19:55253557 rs528413442 |
- | 0.0001 | 0.1004 | - | |
| 47_ASP | GLU |
8.3kJPN chr19:55331301 rs557527515 |
- | 0.0005 | 0.1476 | - | |
| 50_HIS | ARG |
gnomAD chr19:55253567 rs138897134 |
- | 0.0526074 | 0.0608 | - | |
| 50_ARG | SER |
gnomAD chr19:55331308 rs1065331 |
- | 0.027586 | - | - | |
| 50_ARG | CYS |
gnomAD chr19:55331308 rs1065331 |
- | 0.00016095 | - | - | |
| 50_ARG | HIS |
gnomAD chr19:55365343 rs1048271 |
- | 0.000105234 | - | - | |
| 50_ARG | CYS |
8.3kJPN chr19:55284925 rs375476159 |
- | 0.0001 | - | - | |
| 50_ARG | HIS |
8.3kJPN chr19:55284926 rs779537643 |
- | 0.0004 | - | - | |
| 50_ARG | SER |
8.3kJPN chr19:55331308 rs1065331 |
- | 0.0819 | - | - | |
| 52_VAL | ILE |
gnomAD chr19:55331314 rs200785070 |
- | 0.000554821 | - | - | |
| 52_VAL | ILE |
gnomAD chr19:55365348 rs765924648 |
- | 0.000156991 | - | - | |
| 52_VAL | ASP |
gnomAD chr19:55365349 rs753649744 |
- | 0.000155376 | - | - | |
| 52_ILE | THR |
8.3kJPN chr19:55253573 rs375806044 |
- | 0.0001 | 0.0478 | - | |
| 52_VAL | ILE |
8.3kJPN chr19:55331314 rs200785070 |
- | 0.0002 | - | - | |
| 57_ASP | HIS |
8.3kJPN chr19:55331329 rs1436445455 |
- | 0.0001 | 0.1232 | - | |
| 58_GLY | ARG |
gnomAD chr19:55365366 rs778873577 |
- | 0.000354021 | 0.1399 | - | |
| 59_VAL | ILE |
gnomAD chr19:55253593 rs374831310 |
- | 0.00193506 | 0.0802 | - | |
| 59_VAL | ILE |
8.3kJPN chr19:55253593 rs374831310 |
- | 0.0087 | 0.0802 | - | |
| 62_ALA | THR |
gnomAD chr19:55365378 rs201148505 |
- | 0.000759532 | 0.19 | - | |
| 62_ALA | THR |
8.3kJPN chr19:55365378 rs201148505 |
- | 0.0016 | 0.19 | - | |
| 65_SER | PHE |
gnomAD chr19:55284971 rs765722009 |
- | 0.000151782 | 0.1902 | - | |
| 66_ILE | VAL |
8.3kJPN chr19:55331356 rs766260694 |
- | 0.0001 | 0.0909 | - | |
| 67_SER | GLY |
gnomAD chr19:55284976 rs79002558 |
- | 0.000906436 | - | - | |
| 67_GLY | SER |
gnomAD chr19:55365393 rs549170504 |
- | 0.000285138 | 0.1039 | - | |
| 67_SER | GLY |
8.3kJPN chr19:55284976 rs79002558 |
- | 0.0002 | - | - | |
| 68_PRO | ARG |
gnomAD chr19:55331363 rs559245017 |
- | 0.0009523 | 0.0698 | - | |
| 68_ARG | HIS |
8.3kJPN chr19:55284980 rs543746914 |
- | 0.0008 | - | - | |
| 70_THR | MET |
gnomAD chr19:55284986 rs687485 |
- | 0.000155822 | - | - | |
| 70_THR | MET |
8.3kJPN chr19:55284986 rs687485 |
- | 0.0004 | - | - | |
| 71_GLN | GLU |
gnomAD chr19:55253629 rs202138501 |
- | 0.000205224 | 0.0536 | - | |
| 72_ASP | GLU |
8.3kJPN chr19:55253634 - |
- | 0.0001 | 0.1445 | - | |
| 75_GLY | ARG |
8.3kJPN chr19:55285000 - |
- | 0.0001 | 0.4848 | - | |
| 76_THR | ILE |
gnomAD chr19:55331387 rs200893904 |
- | 0.000131348 | 0.2056 | - | |
| 84_THR | PRO |
8.3kJPN chr19:55285027 rs375614836 |
- | 0.0004 | 0.055 | - | |
| 87_PRO | SER |
gnomAD chr19:55331419 rs2273731 |
- | 0.328633 | 0.1377 | - | |
| 87_PRO | SER |
8.3kJPN chr19:55331419 rs2273731 |
- | 0.1442 | 0.1377 | - | |
| 87_PRO | ARG |
8.3kJPN chr19:55365454 - |
- | 0.0001 | 0.1135 | - | |
| 89_GLN | GLU |
gnomAD chr19:55331425 rs201727627 |
- | 0.000107124 | 0.0607 | - | |
| 90_LEU | VAL |
8.3kJPN chr19:55253686 rs558985279 |
- | 0.0001 | 0.1208 | - | |
| 91_SER | PRO |
8.3kJPN chr19:55285048 - |
- | 0.0005 | 0.6384 | - | |
| 92_ALA | ASP |
gnomAD chr19:55253693 rs758501092 |
- | 0.000293678 | 0.1562 | - | |
| 94_SER | GLY |
8.3kJPN chr19:55285057 rs767881326 |
- | 0.0007 | 0.3165 | - | |
| 99_ILE | VAL |
gnomAD chr19:55285072 rs138345877 |
- | 0.0166649 | 0.1216 | - | |
| 99_ILE | VAL |
8.3kJPN chr19:55285072 rs138345877 |
- | 0.0001 | 0.1216 | - | |
| 99_ILE | MET |
8.3kJPN chr19:55285074 rs757326433 |
- | 0.0002 | 0.1372 | - | |
| 100_VAL | MET |
8.3kJPN chr19:55285075 rs745719124 |
- | 0.0001 | 0.1112 | - | |
| 100_VAL | MET |
8.3kJPN chr19:55331458 rs771673513 |
- | 0.0002 | 0.1112 | - | |
| 114_PRO | LEU |
gnomAD chr19:55255276 rs145271800 |
- | 0.000674338 | 0.1291 | - | |
| 114_LEU | PRO |
gnomAD chr19:55286650 rs11673144 |
- | 0.301991 | - | - | |
| 114_PRO | LEU |
8.3kJPN chr19:55255276 rs145271800 |
- | 0.0001 | 0.1291 | - | |
| 114_LEU | PRO |
8.3kJPN chr19:55286650 rs11673144 |
- | 0.1012 | - | - | |
| 116_PRO | HIS |
8.3kJPN chr19:55255282 rs558508248 |
- | 0.0005 | 0.1741 | - | |
| 119_LEU | GLN |
gnomAD chr19:55286665 rs199644153 |
- | 0.00112087 | 0.0534 | - | |
| 119_LEU | GLN |
8.3kJPN chr19:55286665 rs199644153 |
- | 0.0005 | 0.0534 | - | |
| 120_ALA | THR |
gnomAD chr19:55286667 rs145961423 |
- | 0.00137108 | 0.1043 | - | |
| 123_SER | THR |
8.3kJPN chr19:55255303 rs368954426 |
- | 0.0002 | 0.0842 | - | |
| 123_ASN | SER |
8.3kJPN chr19:55286677 rs574769826 |
- | 0.0004 | - | - | |
| 123_SER | GLY |
8.3kJPN chr19:55333079 - |
- | 0.0001 | 0.0971 | - | |
| 124_VAL | MET |
gnomAD chr19:55367136 rs1007714308 |
- | 0.0003663 | 0.1204 | - | |
| 124_VAL | LEU |
8.3kJPN chr19:55286679 rs1371762955 |
- | 0.0001 | 0.2554 | - | |
| 126_LEU | PHE |
8.3kJPN chr19:55286687 - |
- | 0.0001 | 0.2306 | - | |
| 131_ARG | GLN |
gnomAD chr19:55255327 rs200535552 |
- | 0.00195849 | 0.0701 | - | |
| 131_ARG | GLN |
gnomAD chr19:55333104 rs200594305 |
- | 0.000972221 | 0.0701 | - | |
| 131_TRP | ARG |
gnomAD chr19:55367157 rs748512557 |
- | 0.00132626 | - | - | |
| 131_ARG | TRP |
8.3kJPN chr19:55255326 rs200426472 |
- | 0.0055 | 0.0784 | - | |
| 134_TYR | HIS |
gnomAD chr19:55255335 rs756206596 |
- | 0.000181229 | 0.3323 | - | |
| 136_ILE | MET |
gnomAD chr19:55367174 rs374110425 |
- | 0.00370737 | - | - | |
| 138_HIS | ARG |
gnomAD chr19:55255348 rs574746076 |
- | 0.00072203 | 0.1389 | - | |
| 138_HIS | ARG |
8.3kJPN chr19:55255348 rs574746076 |
- | 0.0073 | 0.1389 | - | |
| 138_HIS | ARG |
8.3kJPN chr19:55367179 rs1313723676 |
- | 0.0007 | 0.1389 | - | |
| 140_SER | PHE |
8.3kJPN chr19:55333131 - |
- | 0.0001 | 0.1353 | - | |
| 141_ARG | THR |
8.3kJPN chr19:55255357 rs201504521 |
- | 0.0066 | 0.1894 | - | |
| 141_ARG | THR |
8.3kJPN chr19:55286731 rs201198863 |
- | 0.0008 | 0.1894 | - | |
| 142_GLU | ASP |
gnomAD chr19:55333138 rs112686751 |
- | 0.000729098 | 0.1181 | - | |
| 142_GLU | GLY |
gnomAD chr19:55367191 rs776217262 |
- | 0.00167504 | 0.134 | - | |
| 142_GLU | LYS |
8.3kJPN chr19:55286733 - |
- | 0.0001 | 0.1229 | - | |
| 143_GLY | ARG |
gnomAD chr19:55333139 rs1049215 |
- | 0.112382 | 0.1854 | - | |
| 143_GLY | ARG |
8.3kJPN chr19:55333139 rs1049215 |
- | 0.0004 | 0.1854 | - | |
| 144_GLU | LYS |
gnomAD chr19:55286739 rs373043299 |
- | 0.000114619 | 0.0897 | - | |
| 147_GLU | LYS |
8.3kJPN chr19:55286748 rs1448428716 |
- | 0.0001 | 0.1138 | - | |
| 148_ARG | PRO |
gnomAD chr19:55255378 rs199625806 |
- | 0.00839528 | - | - | |
| 148_ARG | HIS |
gnomAD chr19:55367209 rs759038729 |
- | 0.000162417 | - | - | |
| 148_ARG | PRO |
8.3kJPN chr19:55255378 rs199625806 |
- | 0.0081 | - | - | |
| 148_ARG | HIS |
8.3kJPN chr19:55286752 rs377404034 |
- | 0.0001 | - | - | |
| 150_LEU | PHE |
8.3kJPN chr19:55286757 rs202205602 |
- | 0.0091 | - | - | |
| 150_LEU | PHE |
8.3kJPN chr19:55367214 - |
- | 0.0003 | - | - | |
| 151_PRO | ARG |
gnomAD chr19:55286761 rs200879366 |
- | 0.00127748 | - | - | |
| 151_PRO | SER |
8.3kJPN chr19:55286760 rs200492424 |
- | 0.0139 | - | - | |
| 152_ALA | SER |
8.3kJPN chr19:55286763 - |
- | 0.0001 | 0.1092 | - | |
| 153_GLY | VAL |
gnomAD chr19:55286767 rs200746024 |
- | 0.00569854 | 0.0676 | - | |
| 153_GLY | GLU |
8.3kJPN chr19:55255393 - |
- | 0.0002 | 0.0857 | - | |
| 153_GLY | VAL |
8.3kJPN chr19:55286767 rs200746024 |
- | 0.0027 | 0.0676 | - | |
| 153_VAL | GLY |
8.3kJPN chr19:55333170 - |
- | 0.0001 | - | - | |
| 154_PRO | ARG |
gnomAD chr19:55286770 rs538559888 |
- | 0.00541775 | 0.0718 | - | |
| 154_ARG | HIS |
gnomAD chr19:55333173 rs193921077 |
- | 0.000123614 | - | - | |
| 154_PRO | SER |
8.3kJPN chr19:55255395 - |
- | 0.0001 | 0.1148 | - | |
| 154_PRO | THR |
8.3kJPN chr19:55286769 rs111799279 |
- | 0.0002 | 0.0854 | - | |
| 154_PRO | ARG |
8.3kJPN chr19:55286770 rs538559888 |
- | 0.0027 | 0.0718 | - | |
| 154_ARG | HIS |
8.3kJPN chr19:55333173 rs193921077 |
- | - | - | - | |
| 155_LYS | GLN |
gnomAD chr19:55286772 rs781738613 |
- | 0.000207369 | 0.1188 | - | |
| 155_LYS | ASN |
8.3kJPN chr19:55286774 rs142432377 |
- | 0.0001 | 0.2071 | - | |
| 158_GLY | ARG |
8.3kJPN chr19:55255407 rs180972107 |
- | 0.0001 | 0.1094 | - | |
| 160_PHE | LEU |
8.3kJPN chr19:55255413 - |
- | 0.0007 | 0.7956 | - | |
| 161_GLN | LYS |
gnomAD chr19:55333193 rs201694260 |
- | 0.0128039 | 0.0982 | - | |
| 161_GLN | LYS |
8.3kJPN chr19:55333193 rs201694260 |
- | 0.0222 | 0.0982 | - | |
| 163_ASP | ASN |
gnomAD chr19:55255422 rs373651140 |
- | 0.00049408 | 0.0818 | - | |
| 163_ASP | VAL |
gnomAD chr19:55286797 rs151330111 |
- | 0.00050698 | 0.1389 | - | |
| 163_ASP | ASN |
8.3kJPN chr19:55255422 rs373651140 |
- | 0.0025 | 0.0818 | - | |
| 163_ASP | ASN |
8.3kJPN chr19:55286796 rs147072532 |
- | 0.0001 | 0.0818 | - | |
| 166_LEU | MET |
gnomAD chr19:55367262 rs1414071721 |
- | 0.000113973 | 0.1556 | - | |
| 171_HIS | GLN |
gnomAD chr19:55286822 rs28465191 |
- | 0.0298204 | 0.161 | - | |
| 171_HIS | GLN |
8.3kJPN chr19:55255448 rs200359536 |
- | 0.0019 | 0.161 | - | |
| 171_HIS | GLN |
8.3kJPN chr19:55286822 rs28465191 |
- | 0.0564 | 0.161 | - | |
| 171_HIS | ASN |
8.3kJPN chr19:55333223 rs1235353592 |
- | 0.0001 | 0.1039 | - | |
| 173_GLY | ARG |
gnomAD chr19:55367283 rs762910477 |
- | 0.000343836 | 0.2189 | - | |
| 174_THR | ASN |
gnomAD chr19:55286830 rs147689136 |
- | 0.00018806 | 0.0902 | - | |
| 179_GLY | SER |
gnomAD chr19:55286844 rs111277046 |
- | 0.00168847 | 0.187 | - | |
| 179_GLY | SER |
8.3kJPN chr19:55367301 rs767773688 |
- | 0.0003 | 0.187 | - | |
| 182_ARG | CYS |
gnomAD chr19:55333256 rs112366565 |
- | 0.00610044 | 0.1413 | - | |
| 182_ARG | HIS |
gnomAD chr19:55333257 rs376811176 |
- | 0.000110101 | 0.0805 | - | |
| 182_ARG | CYS |
gnomAD chr19:55367310 rs200625052 |
- | 0.000303626 | 0.1413 | - | |
| 182_ARG | HIS |
gnomAD chr19:55367311 rs113800142 |
- | 0.0826111 | 0.0805 | - | |
| 182_ARG | CYS |
8.3kJPN chr19:55255479 rs1257079474 |
- | 0.0002 | 0.1413 | - | |
| 182_ARG | HIS |
8.3kJPN chr19:55255480 rs199818198 |
- | 0.0005 | 0.0805 | - | |
| 182_ARG | HIS |
8.3kJPN chr19:55367311 rs113800142 |
- | 0.0613 | 0.0805 | - | |
| 183_HIS | ASP |
gnomAD chr19:55333259 rs548514164 |
- | 0.000300035 | - | - | |
| 183_ALA | ASP |
gnomAD chr19:55367314 rs201687607 |
- | 0.0105367 | - | - | |
| 184_SER | ALA |
gnomAD chr19:55333262 rs561931925 |
- | 0.000274052 | 0.0805 | - | |
| 188_TRP | ARG |
gnomAD chr19:55286871 rs755309028 |
- | 0.000120932 | 0.8152 | - | |
| 188_TRP | LEU |
gnomAD chr19:55333275 rs35974949 |
- | 0.298397 | 0.4414 | - | |
| 188_TRP | ARG |
8.3kJPN chr19:55286871 rs755309028 |
- | 0.0086 | 0.8152 | - | |
| 188_TRP | LEU |
8.3kJPN chr19:55333275 rs35974949 |
- | 0.143 | 0.4414 | - | |
| 190_LYS | ASN |
8.3kJPN chr19:55286879 rs753170536 |
- | 0.0001 | - | - | |
| 191_SER | LEU |
8.3kJPN chr19:55367338 - |
- | 0.0001 | 0.1324 | - | |
| 194_PRO | SER |
8.3kJPN chr19:55255515 rs1174321807 |
- | 0.0001 | 0.1756 | - | |
| 199_VAL | ILE |
8.3kJPN chr19:55286904 - |
- | 0.0001 | 0.0967 | - |