PDB ID 1AOI     CHAIN D
Protein name HISTONE H2B
Uniprot Accession P02281
The number of similar proteins 79
The number of binding states 16
The number of binding partners 17

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   KKRRKTRKES   YAIYVYKVLK   QVHPDTGISS   KAMSIMNSFV   NDVFERIAGE   50
51   ASRLAHYNKR   STITSREIQT   AVRLLLPGEL   AKHAVSEGTK   AVTKYTSAK   100

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
24_LYS ARG 8.3kJPN
chr1:149858108
-
- 0.0001 - -
25_LYS ARG 8.3kJPN
chr6:27114492
-
- 0.0001 - -
26_ARG CYS 8.3kJPN
chr6:27100442
rs1239817177
- 0.0001 - -
26_ARG HIS 8.3kJPN
chr6:27861329
-
- 0.0005 - -
28_ARG CYS 8.3kJPN
chr6:26199880
rs764523762
- 0.0001 - -
28_ARG CYS 8.3kJPN
chr6:27100436
rs769130601
- 0.0001 - -
29_THR ILE 8.3kJPN
chr6:25727237
rs147766950
- 0.0001 - -
29_SER ARG 8.3kJPN
chr6:26184120
-
- 0.0001 - -
31_LYS ARG gnomAD
chr1:149783775
rs143086420
- 0.00139572 - -
32_GLU TER 8.3kJPN
chr6:25727245
-
- 0.0001 - -
34_TYR TER 8.3kJPN
chr6:26251992
-
- 0.0001 - -
34_TYR CYS 8.3kJPN
chr6:27100417
rs1305868682
- 0.0001 - -
35_SER CYS gnomAD
chr6:25727255
rs199691595
- 0.000107405 - -
35_SER CYS 8.3kJPN
chr6:26216756
-
- 0.0001 - -
35_SER CYS 8.3kJPN
chr6:26251994
-
- 0.0003 - -
36_VAL ALA 8.3kJPN
chr1:149783760
-
- 0.0001 - -
36_VAL LEU 8.3kJPN
chr6:27775567
rs780283212
- 0.0001 - -
38_VAL LEU 8.3kJPN
chr1:149783755
rs782143987
- 0.0001 - -
40_LYS GLU 8.3kJPN
chr1:228645960
rs1192514228
- 0.0001 - -
41_VAL LEU 8.3kJPN
chr6:26252011
rs774570728
- 0.0003 - -
47_PRO LEU 8.3kJPN
chr6:25727291
rs143128181
- 0.0001 - -
47_PRO SER 8.3kJPN
chr6:26199937
rs1023705388
- 0.0001 - -
47_PRO THR 8.3kJPN
chr6:27100379
rs774667736
- 0.0002 - -
48_ASP ASN 8.3kJPN
chr6:26252032
-
- 0.0001 - -
48_ASP GLY 8.3kJPN
chr6:27782976
-
- 0.0001 - -
49_THR SER 8.3kJPN
chr6:26199944
-
- 0.0001 - -
49_THR ALA 8.3kJPN
chr6:26273360
rs1458054891
- 0.0001 - -
50_GLY ALA 8.3kJPN
chr6:26043725
-
- 0.0001 - -
50_GLY SER 8.3kJPN
chr6:26199946
-
- 0.0001 - -
50_GLY SER 8.3kJPN
chr6:27775525
-
- 0.0001 - -
51_ILE VAL 8.3kJPN
chr6:26216709
-
- 0.0001 - -
52_SER LEU 8.3kJPN
chr1:228645997
rs1353478558
- 0.0001 - -
52_SER PHE 8.3kJPN
chr6:26252045
rs750512885
- 0.0001 - -
53_SER PHE 8.3kJPN
chr6:26043716
-
- 0.0001 - -
53_SER PHE 8.3kJPN
chr6:26252048
rs1391696815
- 0.0001 - -
54_LYS MET 8.3kJPN
chr1:149783706
-
- 0.0001 - -
55_ALA VAL 8.3kJPN
chr6:26043710
-
- 0.0001 - -
56_MET ILE 8.3kJPN
chr1:228646010
rs1440295879
- 0.0001 - -
56_MET LEU 8.3kJPN
chr6:26252056
-
- 0.0001 - -
57_GLY SER 8.3kJPN
chr6:27861421
rs1410298024
- 0.0001 - -
59_MET ILE 8.3kJPN
chr6:27100341
rs1402019530
- 0.0001 - -
60_ASN SER 8.3kJPN
chr6:25727330
rs1237711095
- 0.0001 - -
63_VAL ILE gnomAD
chr6:26043687
rs566958517
- 0.000147129 - -
63_VAL ILE 8.3kJPN
chr1:149783680
rs1438376476
- 0.0001 - -
64_ASN SER 8.3kJPN
chr1:228646033
-
- 0.0001 - -
66_ILE THR gnomAD
chr6:25727348
rs761537792
- 0.000186952 - -
66_ILE VAL gnomAD
chr6:26043678
rs144272993
- 0.000111342 - -
66_ILE VAL 8.3kJPN
chr1:228646038
rs779849447
- 0.0001 - -
66_ILE VAL 8.3kJPN
chr6:25727347
rs774096146
- 0.0001 - -
67_PHE SER 8.3kJPN
chr6:25727351
rs1431133085
- 0.0001 - -
69_ARG CYS 8.3kJPN
chr6:26273420
rs757772183
- 0.0001 - -
69_ARG CYS 8.3kJPN
chr6:27861457
-
- 0.0001 - -
70_ILE LEU 8.3kJPN
chr6:25727359
-
- 0.0001 - -
71_ALA PRO 8.3kJPN
chr6:27775462
-
- 0.0001 - -
72_SER ASN gnomAD
chr6:25727366
rs753295081
- 0.000107417 - -
72_SER ASN 8.3kJPN
chr6:25727366
rs753295081
- 0.0002 - -
72_GLY ASP 8.3kJPN
chr6:26273430
-
- 0.0001 - -
74_ALA VAL gnomAD
chr6:26252111
rs199520662
- 0.000139168 - -
74_ALA SER 8.3kJPN
chr1:149857959
-
- 0.0003 - -
74_ALA VAL 8.3kJPN
chr1:228646063
rs759631368
- 0.0002 - -
75_SER PRO 8.3kJPN
chr1:228646065
-
- 0.0001 - -
76_ARG LEU 8.3kJPN
chr1:228646069
rs1244127669
- 0.0001 - -
76_ARG HIS 8.3kJPN
chr6:26158636
-
- 0.0001 - -
78_ALA SER gnomAD
chr6:25727383
rs150616838
- 0.000143293 - -
78_ALA GLU 8.3kJPN
chr6:26123888
rs752759673
- 0.0001 - -
78_ALA THR 8.3kJPN
chr6:26216628
-
- 0.0001 - -
78_ALA THR 8.3kJPN
chr6:26252122
rs745564288
- 0.0019 - -
79_HIS GLN 8.3kJPN
chr6:26216623
-
- 0.0001 - -
79_HIS TYR 8.3kJPN
chr6:26252125
rs755796999
- 0.0001 - -
81_ASN SER 8.3kJPN
chr6:26252132
rs542798893
- 0.0003 - -
82_LYS ARG gnomAD
chr6:26200043
rs151100683
- 0.000421481 - -
84_SER TER 8.3kJPN
chr6:26184286
rs191131837
- 0.0033 - -
86_ILE THR gnomAD
chr6:27861509
rs148188690
- 0.000206855 - -
86_ILE VAL 8.3kJPN
chr6:27861508
-
- 0.0001 - -
89_ARG LYS gnomAD
chr6:27100252
rs116395770
- 0.000170985 - -
89_ARG GLY 8.3kJPN
chr6:26184300
-
- 0.0001 - -
89_ARG LYS 8.3kJPN
chr6:26273481
-
- 0.0001 - -
90_GLU TER 8.3kJPN
chr6:26158677
-
- 0.0001 - -
91_ILE VAL gnomAD
chr1:149857908
rs373633210
- 0.000231162 - -
91_ILE PHE 8.3kJPN
chr6:27806722
-
- 0.0001 - -
92_GLN TER 8.3kJPN
chr6:26043600
-
- 0.0001 - -
92_GLN LEU 8.3kJPN
chr6:26158684
-
- 0.0001 - -
92_GLN LEU 8.3kJPN
chr6:26184310
rs768613673
- 0.0001 - -
94_ALA THR 8.3kJPN
chr6:26043594
-
- 0.0001 - -
98_LEU MET 8.3kJPN
chr6:26043582
-
- 0.0001 - -
98_LEU VAL 8.3kJPN
chr6:26158701
-
- 0.0001 - -
104_ALA SER 8.3kJPN
chr6:27114256
-
- 0.0001 - -
104_ALA THR 8.3kJPN
chr6:27775363
-
- 0.0001 - -
107_ALA THR 8.3kJPN
chr6:27775354
-
- 0.0001 - -
116_THR SER 8.3kJPN
chr6:26200144
-
- 0.0001 - -
117_LYS ARG 8.3kJPN
chr6:26252240
rs752163332
- 0.0001 - -
119_THR SER 8.3kJPN
chr6:26043518
rs1266161609
- 0.0001 - -
120_SER ASN 8.3kJPN
chr6:26043515
rs769308092
- 0.0001 - -
121_SER PHE 8.3kJPN
chr6:25727513
rs201800096
- 0.0004 - -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.