| PDB ID | 1AKJ
|
CHAIN | D |
|---|---|---|---|
| Protein name | T-CELL CORECEPTOR CD8 | ||
| Uniprot Accession | P01732 | ||
| The number of similar proteins | 14 | ||
| The number of binding states | 8 | ||
| The number of binding partners | 5 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1AKJ (CHAIN: D) | |
| 1 |
P01732
P61769
P01892
|
| 2 | Monomeric state |
| 3 |
8EW6
|
| 4 |
2Q3A
|
| 5 |
P01732
P01892
|
| 6 |
P01732
Q95460
|
| 7 |
P01732
7UVF
7UVF
|
| 8 |
P01732
P61769
Q95460
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 40_ARG | HIS |
8.3kJPN chr2:87017672 - |
- | 0.0001 | 0.1318 | - | |
| 42_ALA | GLY |
gnomAD chr2:87017666 rs537395900 |
- | 0.000347027 | 0.1211 | - | |
| 59_ALA | THR |
8.3kJPN chr2:87017616 rs779814071 |
- | 0.0007 | 0.0747 | - | |
| 61_GLU | ASP |
8.3kJPN chr2:87017608 rs1277197922 |
- | 0.0004 | 0.0899 | - | |
| 77_PHE | VAL |
8.3kJPN chr2:87017562 - |
- | 0.0001 | 0.6663 | - | |
| 79_LEU | PHE |
gnomAD chr2:87017556 rs79392961 |
- | 0.0030113 | 0.5055 | - | |
| 90_GLY | SER |
VAR_021020
rs121918660 |
LP/P | - | 0.9602 | CD8 deficiency, familial (CD8 deficiency) [MIM:608957] | |
| 90_GLY | SER |
ClinVar chr2:87017523 rs121918660 |
Pathogenic | - | 0.9602 | Susceptibility to respiratory infections associated with CD8alpha chain mutation [MONDO:MONDO:0012161,MedGen:C1837065,OMIM:608957,Orphanet:169085] | |
| 109_PRO | ARG |
8.3kJPN chr2:87017465 rs368425695 |
- | 0.0001 | 0.2789 | - |