| PDB ID | 1AKJ
|
CHAIN | D |
|---|---|---|---|
| Protein name | T-CELL CORECEPTOR CD8 | ||
| Uniprot Accession | P01732 | ||
| The number of similar proteins | 14 | ||
| The number of binding states | 8 | ||
| The number of binding partners | 5 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1AKJ (CHAIN: D) | |
| 1 |
P01732
P61769
P01892
|
| 2 | Monomeric state |
| 3 |
8EW6
|
| 4 |
2Q3A
|
| 5 |
P01732
P01892
|
| 6 |
P01732
Q95460
|
| 7 |
P01732
7UVF
7UVF
|
| 8 |
P01732
P61769
Q95460
|
Downdload
Molecule viewer
|
Only interaction residues |
|
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Sequence information
|
Variants
| Residue | AA | Source | dbSNP | Clinical Significance |
Allele Frequency (> 0.0001) |
Disease name | |
|---|---|---|---|---|---|---|---|
| 40_ARG | HIS |
8.3kJPN chr2:87017672 |
-
|
- | 0.0001 | - | |
| 42_ALA | GLY |
gnomAD chr2:87017666 |
rs537395900
|
- | 0.000347027 | - | |
| 59_ALA | THR |
8.3kJPN chr2:87017616 |
rs779814071
|
- | 0.0007 | - | |
| 61_GLU | ASP |
8.3kJPN chr2:87017608 |
rs1277197922
|
- | 0.0004 | - | |
| 77_PHE | VAL |
8.3kJPN chr2:87017562 |
-
|
- | 0.0001 | - | |
| 79_LEU | PHE |
gnomAD chr2:87017556 |
rs79392961
|
- | 0.0030113 | - | |
| 90_GLY | SER | VAR_021020 |
rs121918660
|
LP/P | - | CD8 deficiency, familial (CD8 deficiency) [MIM:608957] | |
| 90_GLY | SER |
ClinVar chr2:87017523 |
rs121918660
|
Pathogenic | - | Susceptibility to respiratory infections associated with CD8alpha chain mutation [MONDO:MONDO:0012161,MedGen:C1837065,OMIM:608957,Orphanet:169085] | |
| 109_PRO | ARG |
8.3kJPN chr2:87017465 |
rs368425695
|
- | 0.0001 | - |