PiSITE

PDB ID	6TB2	CHAIN	C
Protein name	Haptoglobin
Uniprot Accession	P00738
The number of similar proteins	6
The number of binding states	5
The number of binding partners	5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	6TB2 (CHAIN: C)
1	A0A0E8IWL6 P68871 P69905
2	P00738
3	P68871 P69905
4	P68871 P69905 I7B1A7
5	P00738 P69905 P68871 I7BA80

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Only interaction residues

#binding
partners

	2
	1
	0

Sequence information

HHHHHHHHVC

GKPKNPANPV

QRILGGHLDA

KGSFPWQAKM

VSHHSLTTGA

TLINEQWLLT

TAKNLFLSHS

ESATAKDIAP

TLTLYVGKKQ

LVEIEKVVLH

100

101

PSYSQVDIGL

IKLKQKVSVN

ERVMPICLPS

KDYAEVGRVG

YVSGWGRNAN

150

151

FKFTDHLKYV

MLPVADQDQC

IRHYEGSTVP

EKKTPKSPVG

VQPILNEHTF

200

201

CAGMSKYQED

TCYGDAGSAF

AVHDLEEDTW

YATGILSFDK

SCAVAEYGVY

250

251

VKVTSIQDWV

QKTIAEN

300

Variants

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
151_LYS	MET	8.3kJPN chr16:72110211 -	-	0.0001	0.2827	-
153_LYS	GLU	8.3kJPN chr16:72110216 -	-	0.0001	0.0957	-
155_PRO	ARG	gnomAD chr16:72094032 rs562787662	-	0.000145127	0.1598	-
155_PRO	LEU	8.3kJPN chr16:72094032 rs562787662	-	0.0001	0.1656	-
158_PRO	ALA	gnomAD chr16:72110231 rs560060008	-	0.000312207	0.0646	-
166_HIS	GLN	gnomAD chr16:72110257 rs201615147	-	0.000375309	0.1119	-
166_HIS	GLN	8.3kJPN chr16:72110257 rs201615147	-	0.0198	0.1119	-
175_TRP	TER	8.3kJPN chr16:72110283 rs531532112	-	0.0008	-	-
180_VAL	PHE	8.3kJPN chr16:72094106 -	-	0.0001	0.1681	-
214_ALA	VAL	gnomAD chr16:72110400 rs1049933	-	0.00854869	0.1259	-
217_ILE	THR	gnomAD chr16:72110409 rs200632830	-	0.00050146	0.4556	-
217_ILE	THR	8.3kJPN chr16:72110409 rs200632830	-	0.0001	0.4556	-
236_VAL	ALA	gnomAD chr16:72094275 rs375993947	-	0.00011226	0.3887	-
240_PRO	LEU	8.3kJPN chr16:72110478 rs757811087	-	0.0001	0.3914	-
243_HIS	TYR	gnomAD chr16:72110486 rs574707341	-	0.000168384	-	-
243_HIS	PRO	gnomAD chr16:72110487 rs675948	-	0.000172383	-	-
243_HIS	TYR	8.3kJPN chr16:72110486 rs574707341	-	0.0147	-	-
243_HIS	PRO	8.3kJPN chr16:72110487 rs675948	-	0.0147	-	-
246_ASP	GLY	8.3kJPN chr16:72110496 -	-	0.0001	0.927	-
247_ILE	THR	VAR_066214 rs104894517	LP/P	-	0.356	Anhaptoglobinemia (AHP) [MIM:614081]
247_ILE	THR	gnomAD chr16:72110499 rs199591333	-	0.000132315	0.356	-
249_LEU	PRO	8.3kJPN chr16:72110505 -	-	0.001	0.9967	-
257_LEU	PHE	gnomAD chr16:72110528 rs200495504	-	0.000637361	-	-
257_LEU	PRO	gnomAD chr16:72110529 rs201896057	-	0.000637336	-	-
257_LEU	PHE	8.3kJPN chr16:72110528 rs200495504	-	0.0049	-	-
257_LEU	PRO	8.3kJPN chr16:72110529 rs201896057	-	0.0049	-	-
261_ARG	LYS	gnomAD chr16:72110541 rs2021171	-	0.0411582	0.0694	-
261_ARG	LYS	8.3kJPN chr16:72110541 rs2021171	-	0.0482	0.0694	-
263_MET	LYS	8.3kJPN chr16:72110547 -	-	0.0001	0.5121	-
268_PRO	THR	8.3kJPN chr16:72110561 -	-	0.0001	0.3347	-
271_ASN	ASP	gnomAD chr16:72110570 rs375115348	-	0.000124254	-	-
271_ASP	ASN	8.3kJPN chr16:72094379 rs189039907	-	0.0001	0.0959	-
277_ARG	HIS	gnomAD chr16:72094398 rs200200966	-	0.000152339	0.1389	-
277_ARG	HIS	gnomAD chr16:72110589 rs144648182	-	0.00123846	0.1389	-
277_ARG	CYS	8.3kJPN chr16:72094397 rs760921268	-	0.0001	0.476	-
277_ARG	HIS	8.3kJPN chr16:72094398 rs200200966	-	0.0001	0.1389	-
277_ARG	CYS	8.3kJPN chr16:72110588 rs762990031	-	0.0001	0.476	-
277_ARG	HIS	8.3kJPN chr16:72110589 rs144648182	-	0.0092	0.1389	-
286_ARG	GLN	gnomAD chr16:72094425 rs201130844	-	0.00026073	0.2175	-
286_ARG	PRO	8.3kJPN chr16:72094425 rs201130844	-	0.0007	0.979	-
292_PHE	LEU	8.3kJPN chr16:72094442 rs769601309	-	0.0011	0.8901	-
293_THR	ASN	gnomAD chr16:72110637 rs147899609	-	0.00603709	0.2666	-
304_ALA	ASP	8.3kJPN chr16:72110670 -	-	0.0001	0.7682	-
308_GLN	HIS	8.3kJPN chr16:72094492 rs538293575	-	0.0001	0.1139	-
311_THR	MET	8.3kJPN chr16:72110691 rs764873631	-	0.0001	-	-
312_HIS	ARG	gnomAD chr16:72110694 rs763626797	-	0.000328752	0.2227	-
312_HIS	GLN	gnomAD chr16:72110695 rs201323582	-	0.000140318	0.4227	-
315_GLY	ASP	8.3kJPN chr16:72110703 rs201744401	-	0.0001	0.1166	-
317_THR	PRO	8.3kJPN chr16:72110708 -	-	0.0001	0.118	-
320_GLU	LYS	8.3kJPN chr16:72094526 rs779931784	-	0.0001	0.1251	-
320_LYS	ASN	8.3kJPN chr16:72110719 -	-	0.0001	-	-
334_LEU	PRO	8.3kJPN chr16:72110760 -	-	0.0001	0.8737	-
341_VAL	ALA	gnomAD chr16:72110781 rs1065360	-	0.0414842	-	-
341_VAL	ALA	8.3kJPN chr16:72110781 rs1065360	-	0.0483	-	-
342_GLY	SER	gnomAD chr16:72110783 rs201688913	-	0.000240487	0.4556	-
344_SER	CYS	8.3kJPN chr16:72110790 rs746207251	-	0.0026	0.7126	-
355_ALA	VAL	gnomAD chr16:72110823 rs368733337	-	0.000104193	0.6773	-
355_ALA	VAL	8.3kJPN chr16:72110823 rs368733337	-	0.0006	0.6773	-
356_GLY	ASP	gnomAD chr16:72110826 rs374535436	-	0.000144259	0.989	-
372_THR	ALA	gnomAD chr16:72094682 rs470428	-	0.000276586	0.0438	-
372_ALA	THR	gnomAD chr16:72110873 rs149194838	-	0.000120212	-	-
372_THR	ALA	8.3kJPN chr16:72094682 rs470428	-	0.0004	0.0438	-
372_THR	ILE	8.3kJPN chr16:72094683 -	-	0.0001	0.2606	-
388_VAL	GLU	8.3kJPN chr16:72110922 rs1257568574	-	0.0001	0.9635	-
396_GLN	ARG	8.3kJPN chr16:72110946 rs151331078	-	0.0007	0.0628	-
397_ASP	HIS	VAR_017114 rs189115161	LB/B	-	0.1592	-
397_ASP	HIS	gnomAD chr16:72094757 rs189115161	-	0.00121485	0.1592	-
397_HIS	ASP	gnomAD chr16:72110948 rs12646	-	0.355901	-	-
397_ASP	HIS	8.3kJPN chr16:72094757 rs189115161	-	0.0003	0.1592	-
397_HIS	ASP	8.3kJPN chr16:72110948 rs12646	-	0.39	-	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

Coloring

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Sequence information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Variants

Reference

	A0A0E8IWL6	Cell wall surface anchor family protein
	P68871	Hemoglobin subunit beta
	P69905	Hemoglobin subunit alpha