| PDB ID | 4WJG
|
CHAIN | C |
|---|---|---|---|
| Protein name | Haptoglobin | ||
| Uniprot Accession | P00738 | ||
| The number of similar proteins | 5 | ||
| The number of binding states | 4 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 4WJG (CHAIN: C) | |
| 1 |
P00738
I7BA80
P69905
P68871
|
| 2 |
P69905
P68871
|
| 3 |
I7B1A7
P69905
P68871
|
| 4 |
P68871
P69905
A0A0E8IWL6
|
Downdload
Molecule viewer
|
Only interaction residues |
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|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 96_PRO | LEU |
gnomAD chr16:72090450 rs371786946 |
- | 0.000256279 | 0.1313 | - | |
| 97_GLU | LYS |
gnomAD chr16:72090452 rs201773535 |
- | 0.00296035 | 0.097 | - | |
| 98_ILE | THR |
gnomAD chr16:72108210 rs201044200 |
- | 0.00016029 | 0.4145 | - | |
| 100_ASN | HIS |
8.3kJPN chr16:72108215 rs152832 |
- | 0.0001 | - | - | |
| 101_GLY | CYS |
gnomAD chr16:72108218 rs763666282 |
- | 0.000112197 | 0.8744 | - | |
| 112_LYS | GLU |
8.3kJPN chr16:72092221 rs1197605628 |
- | 0.0024 | 0.0764 | - | |
| 116_ARG | THR |
gnomAD chr16:72108264 rs152833 |
- | 0.000749337 | - | - | |
| 117_LEU | ARG |
8.3kJPN chr16:72092237 - |
- | 0.0001 | 0.3652 | - | |
| 118_ARG | HIS |
gnomAD chr16:72090516 rs751924863 |
- | 0.000154211 | 0.1001 | - | |
| 118_ARG | CYS |
gnomAD chr16:72108269 rs368767302 |
- | 0.000116206 | 0.2543 | - | |
| 118_ARG | HIS |
8.3kJPN chr16:72092240 rs768960704 |
- | 0.0009 | 0.1001 | - | |
| 118_ARG | CYS |
8.3kJPN chr16:72108269 rs368767302 |
- | 0.0001 | 0.2543 | - | |
| 124_VAL | MET |
8.3kJPN chr16:72093015 - |
- | 0.0001 | 0.144 | - | |
| 129_ASN | ASP |
VAR_005294
rs199926732 |
LB/B | - | 0.0694 | - | |
| 129_ASN | ASP |
gnomAD chr16:72093030 rs199926732 |
- | 0.000264053 | 0.0694 | - | |
| 129_ASN | ASP |
8.3kJPN chr16:72093030 rs199926732 |
- | 0.0001 | 0.0694 | - | |
| 130_GLU | LYS |
VAR_017113
rs200877317 |
LB/B | - | 0.0702 | - | |
| 130_GLU | LYS |
gnomAD chr16:72093033 rs200877317 |
- | 0.000305112 | 0.0702 | - | |
| 130_GLU | LYS |
8.3kJPN chr16:72093033 rs200877317 |
- | 0.0001 | 0.0702 | - | |
| 133_TRP | ARG |
8.3kJPN chr16:72109073 - |
- | 0.0002 | 0.989 | - | |
| 147_ALA | GLY |
8.3kJPN chr16:72109116 - |
- | 0.0001 | 0.1951 | - | |
| 151_LYS | MET |
8.3kJPN chr16:72110211 - |
- | 0.0001 | 0.2827 | - | |
| 153_LYS | GLU |
8.3kJPN chr16:72110216 - |
- | 0.0001 | 0.0957 | - | |
| 155_PRO | ARG |
gnomAD chr16:72094032 rs562787662 |
- | 0.000145127 | 0.1598 | - | |
| 155_PRO | LEU |
8.3kJPN chr16:72094032 rs562787662 |
- | 0.0001 | 0.1656 | - | |
| 162_HIS | GLN |
gnomAD chr16:72110257 rs201615147 |
- | 0.000375309 | 0.1119 | - | |
| 162_HIS | GLN |
8.3kJPN chr16:72110257 rs201615147 |
- | 0.0198 | 0.1119 | - | |
| 171_TRP | TER |
8.3kJPN chr16:72110283 rs531532112 |
- | 0.0008 | - | - | |
| 176_VAL | PHE |
8.3kJPN chr16:72094106 - |
- | 0.0001 | 0.1681 | - | |
| 210_ALA | VAL |
gnomAD chr16:72110400 rs1049933 |
- | 0.00854869 | 0.1259 | - | |
| 213_ILE | THR |
gnomAD chr16:72110409 rs200632830 |
- | 0.00050146 | 0.4556 | - | |
| 213_ILE | THR |
8.3kJPN chr16:72110409 rs200632830 |
- | 0.0001 | 0.4556 | - | |
| 232_VAL | ALA |
gnomAD chr16:72094275 rs375993947 |
- | 0.00011226 | 0.3887 | - | |
| 236_PRO | LEU |
8.3kJPN chr16:72110478 rs757811087 |
- | 0.0001 | 0.3914 | - | |
| 239_HIS | TYR |
gnomAD chr16:72110486 rs574707341 |
- | 0.000168384 | - | - | |
| 239_HIS | PRO |
gnomAD chr16:72110487 rs675948 |
- | 0.000172383 | - | - | |
| 239_HIS | TYR |
8.3kJPN chr16:72110486 rs574707341 |
- | 0.0147 | - | - | |
| 239_HIS | PRO |
8.3kJPN chr16:72110487 rs675948 |
- | 0.0147 | - | - | |
| 242_ASP | GLY |
8.3kJPN chr16:72110496 - |
- | 0.0001 | 0.927 | - | |
| 243_ILE | THR |
VAR_066214
rs104894517 |
LP/P | - | 0.356 | Anhaptoglobinemia (AHP) [MIM:614081] | |
| 243_ILE | THR |
gnomAD chr16:72110499 rs199591333 |
- | 0.000132315 | 0.356 | - | |
| 245_LEU | PRO |
8.3kJPN chr16:72110505 - |
- | 0.001 | 0.9967 | - | |
| 253_LEU | PHE |
gnomAD chr16:72110528 rs200495504 |
- | 0.000637361 | - | - | |
| 253_LEU | PRO |
gnomAD chr16:72110529 rs201896057 |
- | 0.000637336 | - | - | |
| 253_LEU | PHE |
8.3kJPN chr16:72110528 rs200495504 |
- | 0.0049 | - | - | |
| 253_LEU | PRO |
8.3kJPN chr16:72110529 rs201896057 |
- | 0.0049 | - | - | |
| 257_ARG | LYS |
gnomAD chr16:72110541 rs2021171 |
- | 0.0411582 | 0.0694 | - | |
| 257_ARG | LYS |
8.3kJPN chr16:72110541 rs2021171 |
- | 0.0482 | 0.0694 | - | |
| 259_MET | LYS |
8.3kJPN chr16:72110547 - |
- | 0.0001 | 0.5121 | - | |
| 264_PRO | THR |
8.3kJPN chr16:72110561 - |
- | 0.0001 | 0.3347 | - | |
| 267_ASN | ASP |
gnomAD chr16:72110570 rs375115348 |
- | 0.000124254 | - | - | |
| 267_ASP | ASN |
8.3kJPN chr16:72094379 rs189039907 |
- | 0.0001 | 0.0959 | - | |
| 273_ARG | HIS |
gnomAD chr16:72094398 rs200200966 |
- | 0.000152339 | 0.1389 | - | |
| 273_ARG | HIS |
gnomAD chr16:72110589 rs144648182 |
- | 0.00123846 | 0.1389 | - | |
| 273_ARG | CYS |
8.3kJPN chr16:72094397 rs760921268 |
- | 0.0001 | 0.476 | - | |
| 273_ARG | HIS |
8.3kJPN chr16:72094398 rs200200966 |
- | 0.0001 | 0.1389 | - | |
| 273_ARG | CYS |
8.3kJPN chr16:72110588 rs762990031 |
- | 0.0001 | 0.476 | - | |
| 273_ARG | HIS |
8.3kJPN chr16:72110589 rs144648182 |
- | 0.0092 | 0.1389 | - | |
| 282_ARG | GLN |
gnomAD chr16:72094425 rs201130844 |
- | 0.00026073 | 0.2175 | - | |
| 282_ARG | PRO |
8.3kJPN chr16:72094425 rs201130844 |
- | 0.0007 | 0.979 | - | |
| 288_PHE | LEU |
8.3kJPN chr16:72094442 rs769601309 |
- | 0.0011 | 0.8901 | - | |
| 289_THR | ASN |
gnomAD chr16:72110637 rs147899609 |
- | 0.00603709 | 0.2666 | - | |
| 300_ALA | ASP |
8.3kJPN chr16:72110670 - |
- | 0.0001 | 0.7682 | - | |
| 304_GLN | HIS |
8.3kJPN chr16:72094492 rs538293575 |
- | 0.0001 | 0.1139 | - | |
| 307_THR | MET |
8.3kJPN chr16:72110691 rs764873631 |
- | 0.0001 | - | - | |
| 308_HIS | ARG |
gnomAD chr16:72110694 rs763626797 |
- | 0.000328752 | 0.2227 | - | |
| 308_HIS | GLN |
gnomAD chr16:72110695 rs201323582 |
- | 0.000140318 | 0.4227 | - | |
| 311_GLY | ASP |
8.3kJPN chr16:72110703 rs201744401 |
- | 0.0001 | 0.1166 | - | |
| 313_THR | PRO |
8.3kJPN chr16:72110708 - |
- | 0.0001 | 0.118 | - | |
| 316_GLU | LYS |
8.3kJPN chr16:72094526 rs779931784 |
- | 0.0001 | 0.1251 | - | |
| 316_LYS | ASN |
8.3kJPN chr16:72110719 - |
- | 0.0001 | - | - | |
| 330_LEU | PRO |
8.3kJPN chr16:72110760 - |
- | 0.0001 | 0.8737 | - | |
| 337_VAL | ALA |
gnomAD chr16:72110781 rs1065360 |
- | 0.0414842 | - | - | |
| 337_VAL | ALA |
8.3kJPN chr16:72110781 rs1065360 |
- | 0.0483 | - | - | |
| 338_GLY | SER |
gnomAD chr16:72110783 rs201688913 |
- | 0.000240487 | 0.4556 | - | |
| 340_SER | CYS |
8.3kJPN chr16:72110790 rs746207251 |
- | 0.0026 | 0.7126 | - | |
| 351_ALA | VAL |
gnomAD chr16:72110823 rs368733337 |
- | 0.000104193 | 0.6773 | - | |
| 351_ALA | VAL |
8.3kJPN chr16:72110823 rs368733337 |
- | 0.0006 | 0.6773 | - | |
| 352_GLY | ASP |
gnomAD chr16:72110826 rs374535436 |
- | 0.000144259 | 0.989 | - | |
| 368_THR | ALA |
gnomAD chr16:72094682 rs470428 |
- | 0.000276586 | 0.0438 | - | |
| 368_ALA | THR |
gnomAD chr16:72110873 rs149194838 |
- | 0.000120212 | - | - | |
| 368_THR | ALA |
8.3kJPN chr16:72094682 rs470428 |
- | 0.0004 | 0.0438 | - | |
| 368_THR | ILE |
8.3kJPN chr16:72094683 - |
- | 0.0001 | 0.2606 | - | |
| 384_VAL | GLU |
8.3kJPN chr16:72110922 rs1257568574 |
- | 0.0001 | 0.9635 | - | |
| 392_GLN | ARG |
8.3kJPN chr16:72110946 rs151331078 |
- | 0.0007 | 0.0628 | - | |
| 393_ASP | HIS |
VAR_017114
rs189115161 |
LB/B | - | 0.1592 | - | |
| 393_ASP | HIS |
gnomAD chr16:72094757 rs189115161 |
- | 0.00121485 | 0.1592 | - | |
| 393_HIS | ASP |
gnomAD chr16:72110948 rs12646 |
- | 0.355901 | - | - | |
| 393_ASP | HIS |
8.3kJPN chr16:72094757 rs189115161 |
- | 0.0003 | 0.1592 | - | |
| 393_HIS | ASP |
8.3kJPN chr16:72110948 rs12646 |
- | 0.39 | - | - |