PDB ID 4TZ4     CHAIN C
Protein name Protein cereblon
Uniprot Accession Q96SW2
The number of similar proteins 21
The number of binding states 7
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4TZ4 (CHAIN: C)
1 Q16531  
2 Q16531   O60885  
3 Q16531   P15170  
4 6H0F   Q13422  
5 Q16531   Q9BU19  
6 Q16531   P48729  
7 Q9UJQ4   8U15  

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Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   NFDTSLPTSH   TYLGADMEEF   HGRTLHDDDS   CQVIPVLPQV   MMILIPGQTL   50
51   PLQLFHPQEV   SMVRNLIQKD   RTFAVLAYSN   VQEREAQFGT   TAEIYAYREE   100
101   QDFGIEIVKV   KAIGRQRFKV   LELRTQSDGI   QQAKVQILPE   CVLPSTMSAV   150
151   QLESLNKCQI   FPSKPVSRED   QCSYKWWQKY   QKRKFHCANL   TSWPRWLYSL   200
201   YDAETLMDRI   KKQLREWDEN   LKDDSLPSNP   IDFSYRVAAC   LPIDDVLRIQ   250
251   LLKIGSAIQR   LRCELDIMNK   CTSLCCKQCQ   ETEITTKNEI   FSLSLCGPMA   300
301   AYVNPHGYVH   ETLTVYKACN   LNLIGRPSTE   HSWFPGYAWT   VAQCKICASH   350
351   IGWKFTATKK   DMSPQKFWGL   TRSALLPTIP   D     400

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
54_PRO LEU 8.3kJPN
chr3:3216860
-
- 0.0001 0.8819 -
60_LEU VAL 8.3kJPN
chr3:3215942
-
- 0.0001 0.7335 -
79_GLN TER ClinVar
chr3:3215885
rs377356443
Likely pathogenic - - not provided [MedGen:C3661900]
89_MET ILE 8.3kJPN
chr3:3215853
rs760055652
- 0.0005 0.1738 -
111_ARG GLN 8.3kJPN
chr3:3215788
rs151127854
- 0.0001 0.1375 -
145_ARG TER ClinVar
chr3:3214554
rs1302797003
Pathogenic - - Intellectual disability, autosomal recessive 2|not provided [MONDO:MONDO:0011828,MedGen:C1843942,OMIM:607417,Orphanet:88616|MedGen:CN517202]
197_VAL ILE gnomAD
chr3:3209416
rs201974649
- 0.000274679 0.0723 -
203_ASN SER 8.3kJPN
chr3:3209397
rs1021621569
- 0.0001 0.0614 -
242_ARG CYS gnomAD
chr3:3197929
rs541404259
- 0.000266527 0.0823 -
264_TRP TER ClinVar
chr3:3196475
rs1450725934
Likely pathogenic - - not provided [MedGen:C3661900]
301_ILE THR 8.3kJPN
chr3:3195693
rs758001907
- 0.0001 0.3682 -
307_ARG LEU 8.3kJPN
chr3:3195675
rs752048403
- 0.0001 0.9852 -
313_ASP HIS gnomAD
chr3:3195658
rs142337178
- 0.000103478 0.6697 -
316_ASN HIS 8.3kJPN
chr3:3195649
-
- 0.0001 0.1033 -
347_ALA VAL 8.3kJPN
chr3:3194248
-
- 0.0001 0.9043 -
367_ASN ILE ClinVar
chr3:3194188
rs1575079076
Likely pathogenic - 0.8787 Multiple myeloma [Human Phenotype Ontology:HP:0006775,MONDO:MONDO:0009693,MeSH:D009101,MedGen:C0026764,OMIM:254500,Orphanet:29073,Orphanet:85443]
373_ARG GLN 8.3kJPN
chr3:3194170
rs573677293
- 0.0004 0.1208 -
391_CYS ARG VAR_079409
rs797045036
LP/P - 0.9997 Intellectual developmental disorder, autosomal recessive 2 (MRT2) [MIM:607417]
391_CYS ARG ClinVar
chr3:3192707
rs797045036
Likely pathogenic - 0.9997 Intellectual disability, autosomal recessive 2|not provided [MONDO:MONDO:0011828,MedGen:C1843942,OMIM:607417,Orphanet:88616|MedGen:C3661900]
411_PRO HIS 8.3kJPN
chr3:3192646
-
- 0.0001 0.9958 -
411_PRO SER 8.3kJPN
chr3:3192647
-
- 0.0001 0.9956 -
418_THR MET 8.3kJPN
chr3:3192625
rs1367633045
- 0.0001 0.4757 -
425_THR MET gnomAD
chr3:3192604
rs566932471
- 0.000832073 0.0962 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.