PDB ID 4HSU     CHAIN C
Protein name Histone H3
Uniprot Accession Q92133
The number of similar proteins 13
The number of binding states 6
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4HSU (CHAIN: C)
1 Q49A26   Q8NB78  
2 F7BJB9  
3 Q9GYI0  
4 Q9AXT8  
5 C3SHQ8  
6 P26358   P62979   P62979  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   ARTMQTARKS   TGGKAPRKQL   ATKAARKSAP       50

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
1_ALA VAL 8.3kJPN
chr6:26250829 		rs761937041
- 0.0001 -
2_ARG PRO 8.3kJPN
chr6:26197471 		-
- 0.0001 -
2_ARG LEU 8.3kJPN
chr12:31945093 		rs1312740080
- 0.0001 -
5_GLN TER 8.3kJPN
chr1:149785221 		rs1553755012
- 0.0002 -
5_GLN LYS 8.3kJPN
chr1:228613011 		-
- 0.0001 -
5_GLN TER 8.3kJPN
chr6:26197463 		-
- 0.0001 -
7_ALA THR gnomAD
chr1:228613005 		rs114860054
- 0.00315384 -
8_ARG HIS gnomAD
chr12:31945075 		rs567948186
- 0.000431234 -
8_ARG CYS 8.3kJPN
chr1:228613002 		rs147766330
- 0.0001 -
9_LYS GLU ClinVar
chr17:73775228 		rs2143631415
Likely pathogenic - Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]; Delayed speech and language development [Human Phenotype Ontology:HP:0000750,Human Phenotype Ontology:HP:0002116,Human Phenotype Ontology:HP:0002117,Human Phenotype Ontology:HP:0002336,Human Phenotype Ontology:HP:0002399,Human Phenotype Ontology:HP:0002498,Human Phenotype Ontology:HP:0006936,Human Phenotype Ontology:HP:0007004,Human Phenotype Ontology:HP:0007127,Human Phenotype Ontology:HP:0007170,Human Phenotype Ontology:HP:0007172,MedGen:C0454644]; Short stature [Human Phenotype Ontology:HP:0001509,Human Phenotype Ontology:HP:0003501,Human Phenotype Ontology:HP:0003507,Human Phenotype Ontology:HP:0003512,Human Phenotype Ontology:HP:0003518,Human Phenotype Ontology:HP:0003519,Human Phenotype Ontology:HP:0004322,Human Phenotype Ontology:HP:0008871,Human Phenotype Ontology:HP:0008882,Human Phenotype Ontology:HP:0008888,Human Phenotype Ontology:HP:0008913,MedGen:C0349588]; Brain imaging abnormality [Human Phenotype Ontology:HP:0410263,MedGen:C2711610]; Global developmental delay [Human Phenotype Ontology:HP:0000754,Human Phenotype Ontology:HP:0001255,Human Phenotype Ontology:HP:0001263,Human Phenotype Ontology:HP:0001277,Human Phenotype Ontology:HP:0001292,Human Phenotype Ontology:HP:0002433,Human Phenotype Ontology:HP:0002473,Human Phenotype Ontology:HP:0002532,Human Phenotype Ontology:HP:0006793,Human Phenotype Ontology:HP:0006867,Human Phenotype Ontology:HP:0006885,Human Phenotype Ontology:HP:0006935,Human Phenotype Ontology:HP:0007005,Human Phenotype Ontology:HP:0007094,Human Phenotype Ontology:HP:0007106,Human Phenotype Ontology:HP:0007174,Human Phenotype Ontology:HP:0007224,Human Phenotype Ontology:HP:0007228,Human Phenotype Ontology:HP:0007342,Human Phenotype Ontology:HP:0025356,MedGen:C0557874]
10_SER PRO ClinVar
chr17:73775225 		rs2143631409
Pathogenic - not provided [MedGen:C3661900]
11_THR ILE ClinVar
chr17:73775221 		-
Likely pathogenic - Bryant-Li-Bhoj neurodevelopmental syndrome 2 [MONDO:MONDO:0030607,MedGen:C5676906,OMIM:619721]
11_THR ALA 8.3kJPN
chr6:26045672 		rs750814944
- 0.0001 -
11_THR SER 8.3kJPN
chr6:27777885 		-
- 0.0001 -
11_THR ILE 8.3kJPN
chr6:27777886 		rs1161634758
- 0.0001 -
12_GLY SER ClinVar
chr17:73775219 		rs11547391
Likely pathogenic - not provided [MedGen:C3661900]
12_GLY SER gnomAD
chr12:31945064 		rs61745042
- 0.00828174 -
12_GLY ARG 8.3kJPN
chr1:228612990 		rs1397772335
- 0.0001 -
13_GLY ASP 8.3kJPN
chr6:26271572 		-
- 0.0001 -
15_ALA VAL gnomAD
chr1:228612980 		rs571515258
- 0.00014814 -
17_ARG GLY ClinVar
chr1:226252104 		rs2102735576
Pathogenic - Bryant-Li-Bhoj neurodevelopmental syndrome 1|not provided [MONDO:MONDO:0030606,MedGen:C5676905,OMIM:619720|MedGen:C3661900]
17_ARG CYS ClinVar
chr17:73775204 		-
Likely pathogenic - Bryant-Li-Bhoj neurodevelopmental syndrome 2 [MONDO:MONDO:0030607,MedGen:C5676906,OMIM:619721]
17_ARG HIS gnomAD
chr12:31945048 		rs754427138
- 0.000115508 -
22_THR LYS ClinVar
chr17:73775188 		rs2143631320
Likely pathogenic - Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]; Delayed speech and language development [Human Phenotype Ontology:HP:0000750,Human Phenotype Ontology:HP:0002116,Human Phenotype Ontology:HP:0002117,Human Phenotype Ontology:HP:0002336,Human Phenotype Ontology:HP:0002399,Human Phenotype Ontology:HP:0002498,Human Phenotype Ontology:HP:0006936,Human Phenotype Ontology:HP:0007004,Human Phenotype Ontology:HP:0007127,Human Phenotype Ontology:HP:0007170,Human Phenotype Ontology:HP:0007172,MedGen:C0454644]; Short stature [Human Phenotype Ontology:HP:0001509,Human Phenotype Ontology:HP:0003501,Human Phenotype Ontology:HP:0003507,Human Phenotype Ontology:HP:0003512,Human Phenotype Ontology:HP:0003518,Human Phenotype Ontology:HP:0003519,Human Phenotype Ontology:HP:0004322,Human Phenotype Ontology:HP:0008871,Human Phenotype Ontology:HP:0008882,Human Phenotype Ontology:HP:0008888,Human Phenotype Ontology:HP:0008913,MedGen:C0349588]; Brain imaging abnormality [Human Phenotype Ontology:HP:0410263,MedGen:C2711610]; Global developmental delay [Human Phenotype Ontology:HP:0000754,Human Phenotype Ontology:HP:0001255,Human Phenotype Ontology:HP:0001263,Human Phenotype Ontology:HP:0001277,Human Phenotype Ontology:HP:0001292,Human Phenotype Ontology:HP:0002433,Human Phenotype Ontology:HP:0002473,Human Phenotype Ontology:HP:0002532,Human Phenotype Ontology:HP:0006793,Human Phenotype Ontology:HP:0006867,Human Phenotype Ontology:HP:0006885,Human Phenotype Ontology:HP:0006935,Human Phenotype Ontology:HP:0007005,Human Phenotype Ontology:HP:0007094,Human Phenotype Ontology:HP:0007106,Human Phenotype Ontology:HP:0007174,Human Phenotype Ontology:HP:0007224,Human Phenotype Ontology:HP:0007228,Human Phenotype Ontology:HP:0007342,Human Phenotype Ontology:HP:0025356,MedGen:C0557874]
22_THR ARG ClinVar
chr17:73775188 		rs2143631320
Likely pathogenic - Bryant-Li-Bhoj neurodevelopmental syndrome 2 [MONDO:MONDO:0030607,MedGen:C5676906,OMIM:619721]
22_THR ILE 8.3kJPN
chr1:149785169 		rs1447650068
- 0.0002 -
22_THR ALA 8.3kJPN
chr6:26045705 		rs745690555
- 0.0001 -
22_THR ALA 8.3kJPN
chr6:26225449 		rs200763787
- 0.0041 -
22_THR SER 8.3kJPN
chr6:27777919 		-
- 0.0001 -
26_ARG CYS 8.3kJPN
chr1:228612948 		rs750781461
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.