| PDB ID | 4HRL
|
CHAIN | C |
|---|---|---|---|
| Protein name | Receptor tyrosine-protein kinase erbB-2 | ||
| Uniprot Accession | P04626 | ||
| The number of similar proteins | 5 | ||
| The number of binding states | 5 | ||
| The number of binding partners | 5 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
Downdload
Molecule viewer
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Only interaction residues |
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Sequence information
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Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 9_MET | ILE |
gnomAD chr17:37863262 rs546886845 |
- | 0.000344997 | 0.9313 | - | |
| 19_THR | ILE |
8.3kJPN chr17:37863291 - |
- | 0.0001 | 0.261 | - | |
| 25_ARG | HIS |
gnomAD chr17:37863309 rs144019910 |
- | 0.000713635 | 0.0645 | - | |
| 32_GLN | HIS |
8.3kJPN chr17:37863331 - |
- | 0.0001 | 0.2161 | - | |
| 33_VAL | LEU |
8.3kJPN chr17:37863332 - |
- | 0.0001 | 0.4619 | - | |
| 57_GLU | ALA |
gnomAD chr17:37864584 rs61737968 |
- | 0.000832649 | 0.9075 | - | |
| 78_ARG | TRP |
8.3kJPN chr17:37864646 rs749886389 |
- | 0.0001 | 0.2615 | - | |
| 121_ARG | GLN |
gnomAD chr17:37864776 rs185670819 |
- | 0.000498262 | 0.0896 | - | |
| 121_ARG | GLN |
8.3kJPN chr17:37864776 rs185670819 |
- | 0.0146 | 0.0896 | - | |
| 123_LEU | PHE |
gnomAD chr17:37864781 rs527779103 |
- | 0.000542451 | 0.7322 | - | |
| 135_ARG | TRP |
8.3kJPN chr17:37865600 rs781137961 |
- | 0.0001 | 0.1735 | - | |
| 135_ARG | GLN |
8.3kJPN chr17:37865601 rs745921471 |
- | 0.0001 | 0.0706 | - | |
| 175_PRO | LEU |
8.3kJPN chr17:37866081 rs113619125 |
- | 0.0001 | 0.0782 | - | |
| 180_SER | CYS |
8.3kJPN chr17:37866096 - |
- | 0.0001 | 0.2691 | - |