PDB ID | 3KWQ
|
CHAIN | C |
---|---|---|---|
Protein name | Histone H2A | ||
Uniprot Accession | Q6AZJ8 | ||
The number of similar proteins | 389 | ||
The number of binding states | 23 | ||
The number of binding partners | 13 |
Unicolor (beige)
The number of binding partners
Group
Binding state |
Binding partners |
---|---|
3KWQ (CHAIN: C) | |
1 |
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2 | Monomeric state |
3 |
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4 |
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5 |
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6 |
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7 |
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8 |
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9 |
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10 |
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11 |
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12 |
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13 |
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14 |
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15 |
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16 |
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17 |
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18 |
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19 |
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20 |
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21 |
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22 |
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23 |
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Only interaction residues |
|
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|
Residue | AA | Source | dbSNP | Clinical Significance |
Allele Frequency (> 0.0001) |
Disease name | |
---|---|---|---|---|---|---|---|
14_ALA | GLY |
ClinVar chr6:27833176 |
rs890521687
|
Likely pathogenic | - | Multiple myeloma [Human Phenotype Ontology:HP:0006775,MONDO:MONDO:0009693,MeSH:D009101,MedGen:C0026764,OMIM:254500,Orphanet:29073,Orphanet:85443] | |
14_ALA | VAL |
gnomAD chr1:228645475 |
rs942855
|
- | 0.000198165 | - | |
14_ALA | VAL |
8.3kJPN chr1:228645475 |
rs942855
|
- | 0.0001 | - | |
14_ALA | VAL |
8.3kJPN chr6:26199428 |
rs773531178
|
- | 0.0001 | - | |
14_ALA | THR |
8.3kJPN chr6:27100893 |
rs200399044
|
- | 0.0005 | - | |
14_ALA | THR |
8.3kJPN chr6:27806075 |
rs1006888623
|
- | 0.001 | - | |
15_LYS | ARG |
8.3kJPN chr1:149859420 |
rs1553760178
|
- | 0.0004 | - | |
15_LYS | ARG |
8.3kJPN chr6:27806071 |
-
|
- | 0.0004 | - | |
16_THR | PRO |
8.3kJPN chr6:26217251 |
-
|
- | 0.0001 | - | |
18_SER | TER |
8.3kJPN chr1:228645463 |
rs754510222
|
- | 0.0001 | - | |
19_SER | PHE |
gnomAD chr6:27114966 |
rs770606777
|
- | 0.000107462 | - | |
19_SER | PHE |
gnomAD chr6:27776046 |
rs143049396
|
- | 0.000582671 | - | |
19_SER | ALA |
8.3kJPN chr6:25726698 |
rs761780090
|
- | 0.0001 | - | |
19_SER | PRO |
8.3kJPN chr6:27100908 |
-
|
- | 0.0001 | - | |
19_SER | PHE |
8.3kJPN chr6:27833191 |
rs184589037
|
- | 0.0017 | - | |
20_ARG | TRP |
8.3kJPN chr6:26199411 |
rs763562699
|
- | 0.0001 | - | |
20_ARG | GLN |
8.3kJPN chr6:27114969 |
rs769300562
|
- | 0.0001 | - | |
24_GLN | TER |
8.3kJPN chr6:26199399 |
rs140533379
|
- | 0.0001 | - | |
25_PHE | TYR |
gnomAD chr6:26033720 |
rs145310776
|
- | 0.000218744 | - | |
25_PHE | LEU |
8.3kJPN chr6:26033721 |
-
|
- | 0.0001 | - | |
25_PHE | LEU |
8.3kJPN chr6:26217278 |
-
|
- | 0.0001 | - | |
25_PHE | LEU |
8.3kJPN chr6:27114985 |
-
|
- | 0.0001 | - | |
26_PRO | SER |
8.3kJPN chr6:25726677 |
rs1014929277
|
- | 0.0001 | - | |
26_PRO | SER |
8.3kJPN chr6:26033718 |
rs767532920
|
- | 0.0001 | - | |
31_HIS | GLN |
8.3kJPN chr11:118966009 |
-
|
- | 0.0001 | - | |
32_ARG | TER |
8.3kJPN chr6:27806021 |
-
|
- | 0.0001 | - | |
32_ARG | LEU |
8.3kJPN chr6:27833230 |
-
|
- | 0.0001 | - | |
33_LEU | VAL |
8.3kJPN chr6:27860828 |
-
|
- | 0.0001 | - | |
35_ARG | CYS |
gnomAD chr6:27833238 |
rs576189710
|
- | 0.000171343 | - | |
35_ARG | HIS |
8.3kJPN chr6:25726649 |
rs371440858
|
- | 0.0001 | - | |
35_ARG | CYS |
8.3kJPN chr6:27100956 |
rs772693242
|
- | 0.0001 | - | |
35_ARG | PRO |
8.3kJPN chr6:27833239 |
-
|
- | 0.0002 | - | |
36_LYS | MET |
8.3kJPN chr6:27833242 |
-
|
- | 0.0001 | - | |
37_GLY | SER |
gnomAD chr6:26033685 |
rs369599740
|
- | 0.000139223 | - | |
37_GLY | SER |
8.3kJPN chr1:149858636 |
rs782788423
|
- | 0.0001 | - | |
37_GLY | ARG |
8.3kJPN chr6:25726644 |
rs189327307
|
- | 0.0001 | - | |
37_GLY | SER |
8.3kJPN chr6:27860816 |
rs201009000
|
- | 0.0001 | - | |
38_ASN | SER |
8.3kJPN chr6:27115023 |
rs988081913
|
- | 0.0001 | - | |
39_TYR | CYS |
gnomAD chr6:27115026 |
rs765177021
|
- | 0.000242689 | - | |
39_TYR | CYS |
8.3kJPN chr6:27776106 |
rs754867249
|
- | 0.0001 | - | |
40_ALA | VAL |
8.3kJPN chr1:149858646 |
rs974659430
|
- | 0.0001 | - | |
40_ALA | SER |
8.3kJPN chr1:149859346 |
-
|
- | 0.0001 | - | |
41_GLU | LYS |
8.3kJPN chr6:27100974 |
-
|
- | 0.0001 | - | |
42_ARG | LEU |
gnomAD chr6:26199344 |
rs201200903
|
- | 0.000741591 | - | |
42_ARG | LEU |
gnomAD chr6:27782391 |
rs774407719
|
- | 0.000148075 | - | |
42_ARG | GLN |
8.3kJPN chr6:25726628 |
rs762868475
|
- | 0.0001 | - | |
43_VAL | LEU |
8.3kJPN chr6:27860798 |
rs549660103
|
- | 0.0001 | - | |
45_ALA | SER |
gnomAD chr6:26033661 |
rs201159814
|
- | 0.000171139 | - | |
47_ALA | GLU |
gnomAD chr6:27805975 |
rs149494377
|
- | 0.0124443 | - | |
47_ALA | VAL |
8.3kJPN chr6:27782376 |
rs200522974
|
- | 0.0001 | - | |
47_ALA | SER |
8.3kJPN chr6:27782377 |
rs1250781403
|
- | 0.0001 | - | |
47_ALA | GLU |
8.3kJPN chr6:27805975 |
rs149494377
|
- | 0.0599 | - | |
48_PRO | ARG |
gnomAD chr1:228645373 |
rs143327597
|
- | 0.000233117 | - | |
48_PRO | LEU |
8.3kJPN chr6:25726610 |
rs1417126640
|
- | 0.0001 | - | |
48_PRO | SER |
8.3kJPN chr6:27776132 |
-
|
- | 0.0001 | - | |
49_VAL | LEU |
gnomAD chr6:26199324 |
rs142347437
|
- | 0.000570476 | - | |
49_VAL | LEU |
8.3kJPN chr1:149859319 |
rs782428337
|
- | 0.0002 | - | |
50_TYR | CYS |
8.3kJPN chr6:26199320 |
rs776773287
|
- | 0.0001 | - | |
50_TYR | PHE |
8.3kJPN chr6:27115059 |
-
|
- | 0.0001 | - | |
50_TYR | CYS |
8.3kJPN chr6:27805966 |
rs544484889
|
- | 0.0001 | - | |
51_LEU | ARG |
gnomAD chr6:26199317 |
rs147678711
|
- | 0.000298938 | - | |
51_MET | VAL |
8.3kJPN chr1:149858678 |
rs201477575
|
- | 0.0002 | - | |
52_ALA | GLY |
8.3kJPN chr6:25726598 |
rs375336327
|
- | 0.0001 | - | |
53_ALA | VAL |
gnomAD chr6:27805957 |
rs139301244
|
- | 0.000401977 | - | |
53_ALA | VAL |
gnomAD chr6:27833293 |
rs141399242
|
- | 0.000131374 | - | |
53_ALA | VAL |
8.3kJPN chr1:228645358 |
rs564487637
|
- | 0.0001 | - | |
53_ALA | GLY |
8.3kJPN chr6:26199311 |
-
|
- | 0.0008 | - | |
53_ALA | GLY |
8.3kJPN chr6:27782358 |
-
|
- | 0.0001 | - | |
55_LEU | PHE |
8.3kJPN chr6:26199304 |
-
|
- | 0.0001 | - | |
55_LEU | VAL |
8.3kJPN chr6:26199306 |
rs755825653
|
- | 0.0028 | - | |
57_TYR | SER |
8.3kJPN chr6:26033624 |
-
|
- | 0.0005 | - | |
57_TYR | SER |
8.3kJPN chr6:26124633 |
-
|
- | 0.0002 | - | |
59_THR | ILE |
8.3kJPN chr6:26033618 |
rs545768553
|
- | 0.0001 | - | |
59_THR | ALA |
8.3kJPN chr6:27805940 |
-
|
- | 0.0003 | - | |
60_ALA | PRO |
gnomAD chr6:27833313 |
rs368720914
|
- | 0.000326184 | - | |
61_GLU | TER |
8.3kJPN chr1:149859283 |
-
|
- | 0.0001 | - | |
61_GLU | ASP |
8.3kJPN chr6:27833318 |
-
|
- | 0.0001 | - | |
62_ILE | VAL |
8.3kJPN chr1:149859280 |
rs1559775930
|
- | 0.0001 | - | |
66_ALA | VAL |
8.3kJPN chr6:26033597 |
-
|
- | 0.0001 | - | |
66_ALA | THR |
8.3kJPN chr6:26033598 |
rs1459697118
|
- | 0.0001 | - | |
66_ALA | VAL |
8.3kJPN chr6:27115107 |
rs770769479
|
- | 0.0001 | - | |
66_ALA | THR |
8.3kJPN chr6:27776186 |
-
|
- | 0.0001 | - | |
67_GLY | CYS |
8.3kJPN chr6:27782317 |
-
|
- | 0.0001 | - | |
68_ASN | SER |
gnomAD chr12:14927610 |
rs201674611
|
- | 0.000159125 | - | |
70_ALA | THR |
gnomAD chr6:27805907 |
rs146210589
|
- | 0.00011134 | - | |
71_ARG | HIS |
8.3kJPN chr6:25726541 |
rs771578160
|
- | 0.0001 | - | |
71_ARG | HIS |
8.3kJPN chr6:26033582 |
-
|
- | 0.0001 | - | |
73_ASN | LYS |
gnomAD chr6:27805896 |
rs371861857
|
- | 0.000405586 | - | |
73_ASN | LYS |
8.3kJPN chr1:228645297 |
rs201001912
|
- | 0.0001 | - | |
73_ASN | LYS |
8.3kJPN chr6:27805896 |
rs371861857
|
- | 0.0029 | - | |
73_ASN | LYS |
8.3kJPN chr11:118965883 |
rs780380122
|
- | 0.0001 | - | |
76_THR | ILE |
8.3kJPN chr6:27115137 |
-
|
- | 0.0001 | - | |
77_ARG | CYS |
8.3kJPN chr6:26199240 |
-
|
- | 0.0001 | - | |
77_ARG | HIS |
8.3kJPN chr6:27805885 |
rs746824735
|
- | 0.0001 | - | |
80_PRO | SER |
8.3kJPN chr1:228645278 |
-
|
- | 0.0002 | - | |
80_PRO | THR |
8.3kJPN chr12:14927645 |
-
|
- | 0.0001 | - | |
82_HIS | TYR |
8.3kJPN chr12:14927651 |
-
|
- | 0.0001 | - | |
83_LEU | PHE |
8.3kJPN chr6:27782269 |
rs1391700905
|
- | 0.0001 | - | |
84_GLN | GLU |
8.3kJPN chr6:25726503 |
-
|
- | 0.0001 | - | |
84_GLN | TER |
8.3kJPN chr6:26199219 |
rs770480882
|
- | 0.0001 | - | |
84_GLN | TER |
8.3kJPN chr6:27115160 |
rs143700242
|
- | 0.0001 | - | |
86_ALA | SER |
8.3kJPN chr1:149858783 |
-
|
- | 0.0001 | - | |
87_ILE | VAL |
gnomAD chr6:25726494 |
rs146789964
|
- | 0.000182956 | - | |
87_ILE | THR |
8.3kJPN chr6:27860665 |
-
|
- | 0.0001 | - | |
88_ARG | LEU |
8.3kJPN chr1:228645253 |
-
|
- | 0.0001 | - | |
88_ARG | HIS |
8.3kJPN chr6:27805852 |
-
|
- | 0.0001 | - | |
89_ASN | THR |
8.3kJPN chr12:14927673 |
-
|
- | 0.0001 | - | |
93_LEU | VAL |
gnomAD chr6:26199192 |
rs139406782
|
- | 0.000111336 | - | |
94_ASN | HIS |
8.3kJPN chr6:27776270 |
-
|
- | 0.0001 | - | |
96_LEU | PHE |
8.3kJPN chr6:25726467 |
rs1219098411
|
- | 0.0001 | - | |
97_LEU | VAL |
8.3kJPN chr6:27805826 |
-
|
- | 0.0001 | - | |
97_LEU | PRO |
8.3kJPN chr6:27860635 |
-
|
- | 0.0001 | - | |
99_LYS | ARG |
8.3kJPN chr6:27101149 |
rs753284856
|
- | 0.0001 | - | |
100_VAL | ALA |
8.3kJPN chr6:25726454 |
-
|
- | 0.0001 | - | |
100_VAL | ILE |
8.3kJPN chr6:27782218 |
rs1431545616
|
- | 0.0001 | - | |
109_PRO | SER |
8.3kJPN chr6:27805790 |
rs768172784
|
- | 0.0001 | - | |
110_ASN | SER |
gnomAD chr6:27833464 |
rs144728921
|
- | 0.00281915 | - | |
110_ASN | LYS |
gnomAD chr12:14927737 |
rs1823
|
- | 0.000875058 | - | |
112_GLN | GLU |
8.3kJPN chr6:27805781 |
-
|
- | 0.0004 | - | |
113_ALA | VAL |
8.3kJPN chr12:14927745 |
-
|
- | 0.0001 | - | |
114_VAL | MET |
8.3kJPN chr6:27115250 |
rs768852602
|
- | 0.0007 | - | |
920_THR | MET |
8.3kJPN chr1:228645157 |
rs764047633
|
- | 0.0001 | - | |
920_THR | ALA |
8.3kJPN chr6:26124821 |
-
|
- | 0.0001 | - | |
920_THR | ASN |
8.3kJPN chr6:27860566 |
-
|
- | 0.0001 | - |