| PDB ID | 3KWQ
|
CHAIN | C |
|---|---|---|---|
| Protein name | Histone H2A | ||
| Uniprot Accession | Q6AZJ8 | ||
| The number of similar proteins | 389 | ||
| The number of binding states | 23 | ||
| The number of binding partners | 13 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 3KWQ (CHAIN: C) | |
| 1 |
Q6AZJ8
P62799
P84233
P02281
P02281
|
| 2 | Monomeric state |
| 3 |
P02281
|
| 4 |
P02281
Q96P70
|
| 5 |
P06899
Q9Y5B9
|
| 6 |
Q16778
P38326
|
| 7 |
P62799
P84233
P02281
|
| 8 |
P06897
P62799
P84233
P02281
|
| 9 |
Q6AZJ8
P62799
P84233
P02281
P54784
|
| 10 |
Q6AZJ8
P62799
P84233
P02281
P25171
|
| 11 |
Q6AZJ8
P62799
P84233
P02281
Q99496
|
| 12 |
Q6AZJ8
P62799
P84233
P84233
P02281
|
| 13 |
Q6AZJ8
P62799
P84233
P84233
P02281
P02281
|
| 14 |
Q6AZJ8
P62799
P84233
P84233
P02281
P06701
|
| 15 |
Q6AZJ8
P62799
P84233
P02281
P02281
P06701
|
| 16 |
Q6AZJ8
P62799
P84233
P84233
P02281
P25171
|
| 17 |
Q6AZJ8
P62799
P84233
P02281
P02281
Q99496
|
| 18 |
P04908
P62805
P68431
P06899
P06899
P06899
|
| 19 |
P04908
P62805
P62805
P68431
P68431
P06899
|
| 20 |
Q6AZJ8
Q8IW19
P62799
A0A310TTQ1
A0A1L8FQA5
A0A1L8FQA5
|
| 21 |
P06897
P62799
P84233
P84233
P02281
P02281
A6ZWK1
|
| 22 |
P04908
P62805
P68431
P68431
P06899
P06899
P07305
|
| 23 |
P04908
P04908
P62805
P68431
P68431
P06899
P06899
P06899
|
Downdload
Molecule viewer
|
Only interaction residues |
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|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 14_ALA | GLY |
ClinVar chr6:27833176 rs890521687 |
Likely pathogenic | - | - | Multiple myeloma [Human Phenotype Ontology:HP:0006775,MONDO:MONDO:0009693,MeSH:D009101,MedGen:C0026764,OMIM:254500,Orphanet:29073,Orphanet:85443] | |
| 14_ALA | VAL |
gnomAD chr1:228645475 rs942855 |
- | 0.000198165 | - | - | |
| 14_ALA | VAL |
8.3kJPN chr1:228645475 rs942855 |
- | 0.0001 | - | - | |
| 14_ALA | VAL |
8.3kJPN chr6:26199428 rs773531178 |
- | 0.0001 | - | - | |
| 14_ALA | THR |
8.3kJPN chr6:27100893 rs200399044 |
- | 0.0005 | - | - | |
| 14_ALA | THR |
8.3kJPN chr6:27806075 rs1006888623 |
- | 0.001 | - | - | |
| 15_LYS | ARG |
8.3kJPN chr1:149859420 rs1553760178 |
- | 0.0004 | - | - | |
| 15_LYS | ARG |
8.3kJPN chr6:27806071 - |
- | 0.0004 | - | - | |
| 16_THR | PRO |
8.3kJPN chr6:26217251 - |
- | 0.0001 | - | - | |
| 18_SER | TER |
8.3kJPN chr1:228645463 rs754510222 |
- | 0.0001 | - | - | |
| 19_SER | PHE |
gnomAD chr6:27114966 rs770606777 |
- | 0.000107462 | - | - | |
| 19_SER | PHE |
gnomAD chr6:27776046 rs143049396 |
- | 0.000582671 | - | - | |
| 19_SER | ALA |
8.3kJPN chr6:25726698 rs761780090 |
- | 0.0001 | - | - | |
| 19_SER | PRO |
8.3kJPN chr6:27100908 - |
- | 0.0001 | - | - | |
| 19_SER | PHE |
8.3kJPN chr6:27833191 rs184589037 |
- | 0.0017 | - | - | |
| 20_ARG | TRP |
8.3kJPN chr6:26199411 rs763562699 |
- | 0.0001 | - | - | |
| 20_ARG | GLN |
8.3kJPN chr6:27114969 rs769300562 |
- | 0.0001 | - | - | |
| 24_GLN | TER |
8.3kJPN chr6:26199399 rs140533379 |
- | 0.0001 | - | - | |
| 25_PHE | TYR |
gnomAD chr6:26033720 rs145310776 |
- | 0.000218744 | - | - | |
| 25_PHE | LEU |
8.3kJPN chr6:26033721 - |
- | 0.0001 | - | - | |
| 25_PHE | LEU |
8.3kJPN chr6:26217278 - |
- | 0.0001 | - | - | |
| 25_PHE | LEU |
8.3kJPN chr6:27114985 - |
- | 0.0001 | - | - | |
| 26_PRO | SER |
8.3kJPN chr6:25726677 rs1014929277 |
- | 0.0001 | - | - | |
| 26_PRO | SER |
8.3kJPN chr6:26033718 rs767532920 |
- | 0.0001 | - | - | |
| 31_HIS | GLN |
8.3kJPN chr11:118966009 - |
- | 0.0001 | - | - | |
| 32_ARG | TER |
8.3kJPN chr6:27806021 - |
- | 0.0001 | - | - | |
| 32_ARG | LEU |
8.3kJPN chr6:27833230 - |
- | 0.0001 | - | - | |
| 33_LEU | VAL |
8.3kJPN chr6:27860828 - |
- | 0.0001 | - | - | |
| 35_ARG | CYS |
gnomAD chr6:27833238 rs576189710 |
- | 0.000171343 | - | - | |
| 35_ARG | HIS |
8.3kJPN chr6:25726649 rs371440858 |
- | 0.0001 | - | - | |
| 35_ARG | CYS |
8.3kJPN chr6:27100956 rs772693242 |
- | 0.0001 | - | - | |
| 35_ARG | PRO |
8.3kJPN chr6:27833239 - |
- | 0.0002 | - | - | |
| 36_LYS | MET |
8.3kJPN chr6:27833242 - |
- | 0.0001 | - | - | |
| 37_GLY | SER |
gnomAD chr6:26033685 rs369599740 |
- | 0.000139223 | - | - | |
| 37_GLY | SER |
8.3kJPN chr1:149858636 rs782788423 |
- | 0.0001 | - | - | |
| 37_GLY | ARG |
8.3kJPN chr6:25726644 rs189327307 |
- | 0.0001 | - | - | |
| 37_GLY | SER |
8.3kJPN chr6:27860816 rs201009000 |
- | 0.0001 | - | - | |
| 38_ASN | SER |
8.3kJPN chr6:27115023 rs988081913 |
- | 0.0001 | - | - | |
| 39_TYR | CYS |
gnomAD chr6:27115026 rs765177021 |
- | 0.000242689 | - | - | |
| 39_TYR | CYS |
8.3kJPN chr6:27776106 rs754867249 |
- | 0.0001 | - | - | |
| 40_ALA | VAL |
8.3kJPN chr1:149858646 rs974659430 |
- | 0.0001 | - | - | |
| 40_ALA | SER |
8.3kJPN chr1:149859346 - |
- | 0.0001 | - | - | |
| 41_GLU | LYS |
8.3kJPN chr6:27100974 - |
- | 0.0001 | - | - | |
| 42_ARG | LEU |
gnomAD chr6:26199344 rs201200903 |
- | 0.000741591 | - | - | |
| 42_ARG | LEU |
gnomAD chr6:27782391 rs774407719 |
- | 0.000148075 | - | - | |
| 42_ARG | GLN |
8.3kJPN chr6:25726628 rs762868475 |
- | 0.0001 | - | - | |
| 43_VAL | LEU |
8.3kJPN chr6:27860798 rs549660103 |
- | 0.0001 | - | - | |
| 45_ALA | SER |
gnomAD chr6:26033661 rs201159814 |
- | 0.000171139 | - | - | |
| 47_ALA | GLU |
gnomAD chr6:27805975 rs149494377 |
- | 0.0124443 | - | - | |
| 47_ALA | VAL |
8.3kJPN chr6:27782376 rs200522974 |
- | 0.0001 | - | - | |
| 47_ALA | SER |
8.3kJPN chr6:27782377 rs1250781403 |
- | 0.0001 | - | - | |
| 47_ALA | GLU |
8.3kJPN chr6:27805975 rs149494377 |
- | 0.0599 | - | - | |
| 48_PRO | ARG |
gnomAD chr1:228645373 rs143327597 |
- | 0.000233117 | - | - | |
| 48_PRO | LEU |
8.3kJPN chr6:25726610 rs1417126640 |
- | 0.0001 | - | - | |
| 48_PRO | SER |
8.3kJPN chr6:27776132 - |
- | 0.0001 | - | - | |
| 49_VAL | LEU |
gnomAD chr6:26199324 rs142347437 |
- | 0.000570476 | - | - | |
| 49_VAL | LEU |
8.3kJPN chr1:149859319 rs782428337 |
- | 0.0002 | - | - | |
| 50_TYR | CYS |
8.3kJPN chr6:26199320 rs776773287 |
- | 0.0001 | - | - | |
| 50_TYR | PHE |
8.3kJPN chr6:27115059 - |
- | 0.0001 | - | - | |
| 50_TYR | CYS |
8.3kJPN chr6:27805966 rs544484889 |
- | 0.0001 | - | - | |
| 51_LEU | ARG |
gnomAD chr6:26199317 rs147678711 |
- | 0.000298938 | - | - | |
| 51_MET | VAL |
8.3kJPN chr1:149858678 rs201477575 |
- | 0.0002 | - | - | |
| 52_ALA | GLY |
8.3kJPN chr6:25726598 rs375336327 |
- | 0.0001 | - | - | |
| 53_ALA | VAL |
gnomAD chr6:27805957 rs139301244 |
- | 0.000401977 | - | - | |
| 53_ALA | VAL |
gnomAD chr6:27833293 rs141399242 |
- | 0.000131374 | - | - | |
| 53_ALA | VAL |
8.3kJPN chr1:228645358 rs564487637 |
- | 0.0001 | - | - | |
| 53_ALA | GLY |
8.3kJPN chr6:26199311 - |
- | 0.0008 | - | - | |
| 53_ALA | GLY |
8.3kJPN chr6:27782358 - |
- | 0.0001 | - | - | |
| 55_LEU | PHE |
8.3kJPN chr6:26199304 - |
- | 0.0001 | - | - | |
| 55_LEU | VAL |
8.3kJPN chr6:26199306 rs755825653 |
- | 0.0028 | - | - | |
| 57_TYR | SER |
8.3kJPN chr6:26033624 - |
- | 0.0005 | - | - | |
| 57_TYR | SER |
8.3kJPN chr6:26124633 - |
- | 0.0002 | - | - | |
| 59_THR | ILE |
8.3kJPN chr6:26033618 rs545768553 |
- | 0.0001 | - | - | |
| 59_THR | ALA |
8.3kJPN chr6:27805940 - |
- | 0.0003 | - | - | |
| 60_ALA | PRO |
gnomAD chr6:27833313 rs368720914 |
- | 0.000326184 | - | - | |
| 61_GLU | TER |
8.3kJPN chr1:149859283 - |
- | 0.0001 | - | - | |
| 61_GLU | ASP |
8.3kJPN chr6:27833318 - |
- | 0.0001 | - | - | |
| 62_ILE | VAL |
8.3kJPN chr1:149859280 rs1559775930 |
- | 0.0001 | - | - | |
| 66_ALA | VAL |
8.3kJPN chr6:26033597 - |
- | 0.0001 | - | - | |
| 66_ALA | THR |
8.3kJPN chr6:26033598 rs1459697118 |
- | 0.0001 | - | - | |
| 66_ALA | VAL |
8.3kJPN chr6:27115107 rs770769479 |
- | 0.0001 | - | - | |
| 66_ALA | THR |
8.3kJPN chr6:27776186 - |
- | 0.0001 | - | - | |
| 67_GLY | CYS |
8.3kJPN chr6:27782317 - |
- | 0.0001 | - | - | |
| 68_ASN | SER |
gnomAD chr12:14927610 rs201674611 |
- | 0.000159125 | - | - | |
| 70_ALA | THR |
gnomAD chr6:27805907 rs146210589 |
- | 0.00011134 | - | - | |
| 71_ARG | HIS |
8.3kJPN chr6:25726541 rs771578160 |
- | 0.0001 | - | - | |
| 71_ARG | HIS |
8.3kJPN chr6:26033582 - |
- | 0.0001 | - | - | |
| 73_ASN | LYS |
gnomAD chr6:27805896 rs371861857 |
- | 0.000405586 | - | - | |
| 73_ASN | LYS |
8.3kJPN chr1:228645297 rs201001912 |
- | 0.0001 | - | - | |
| 73_ASN | LYS |
8.3kJPN chr6:27805896 rs371861857 |
- | 0.0029 | - | - | |
| 73_ASN | LYS |
8.3kJPN chr11:118965883 rs780380122 |
- | 0.0001 | - | - | |
| 76_THR | ILE |
8.3kJPN chr6:27115137 - |
- | 0.0001 | - | - | |
| 77_ARG | CYS |
8.3kJPN chr6:26199240 - |
- | 0.0001 | - | - | |
| 77_ARG | HIS |
8.3kJPN chr6:27805885 rs746824735 |
- | 0.0001 | - | - | |
| 80_PRO | SER |
8.3kJPN chr1:228645278 - |
- | 0.0002 | - | - | |
| 80_PRO | THR |
8.3kJPN chr12:14927645 - |
- | 0.0001 | - | - | |
| 82_HIS | TYR |
8.3kJPN chr12:14927651 - |
- | 0.0001 | - | - | |
| 83_LEU | PHE |
8.3kJPN chr6:27782269 rs1391700905 |
- | 0.0001 | - | - | |
| 84_GLN | GLU |
8.3kJPN chr6:25726503 - |
- | 0.0001 | - | - | |
| 84_GLN | TER |
8.3kJPN chr6:26199219 rs770480882 |
- | 0.0001 | - | - | |
| 84_GLN | TER |
8.3kJPN chr6:27115160 rs143700242 |
- | 0.0001 | - | - | |
| 86_ALA | SER |
8.3kJPN chr1:149858783 - |
- | 0.0001 | - | - | |
| 87_ILE | VAL |
gnomAD chr6:25726494 rs146789964 |
- | 0.000182956 | - | - | |
| 87_ILE | THR |
8.3kJPN chr6:27860665 - |
- | 0.0001 | - | - | |
| 88_ARG | LEU |
8.3kJPN chr1:228645253 - |
- | 0.0001 | - | - | |
| 88_ARG | HIS |
8.3kJPN chr6:27805852 - |
- | 0.0001 | - | - | |
| 89_ASN | THR |
8.3kJPN chr12:14927673 - |
- | 0.0001 | - | - | |
| 93_LEU | VAL |
gnomAD chr6:26199192 rs139406782 |
- | 0.000111336 | - | - | |
| 94_ASN | HIS |
8.3kJPN chr6:27776270 - |
- | 0.0001 | - | - | |
| 96_LEU | PHE |
8.3kJPN chr6:25726467 rs1219098411 |
- | 0.0001 | - | - | |
| 97_LEU | VAL |
8.3kJPN chr6:27805826 - |
- | 0.0001 | - | - | |
| 97_LEU | PRO |
8.3kJPN chr6:27860635 - |
- | 0.0001 | - | - | |
| 99_LYS | ARG |
8.3kJPN chr6:27101149 rs753284856 |
- | 0.0001 | - | - | |
| 100_VAL | ALA |
8.3kJPN chr6:25726454 - |
- | 0.0001 | - | - | |
| 100_VAL | ILE |
8.3kJPN chr6:27782218 rs1431545616 |
- | 0.0001 | - | - | |
| 109_PRO | SER |
8.3kJPN chr6:27805790 rs768172784 |
- | 0.0001 | - | - | |
| 110_ASN | SER |
gnomAD chr6:27833464 rs144728921 |
- | 0.00281915 | - | - | |
| 110_ASN | LYS |
gnomAD chr12:14927737 rs1823 |
- | 0.000875058 | - | - | |
| 112_GLN | GLU |
8.3kJPN chr6:27805781 - |
- | 0.0004 | - | - | |
| 113_ALA | VAL |
8.3kJPN chr12:14927745 - |
- | 0.0001 | - | - | |
| 114_VAL | MET |
8.3kJPN chr6:27115250 rs768852602 |
- | 0.0007 | - | - | |
| 920_THR | MET |
8.3kJPN chr1:228645157 rs764047633 |
- | 0.0001 | - | - | |
| 920_THR | ALA |
8.3kJPN chr6:26124821 - |
- | 0.0001 | - | - | |
| 920_THR | ASN |
8.3kJPN chr6:27860566 - |
- | 0.0001 | - | - |