PiSITE

PDB ID	7TV4	CHAIN	B
Protein name	NF-kappa-B essential modulator
Uniprot Accession	Q9Y6K9
The number of similar proteins	20
The number of binding states	8
The number of binding partners	4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	7TV4 (CHAIN: B)
1	Q9Y6K9 Q96EP0 P0CG48 P0CG48
2	Q9Y6K9
3	Q9Y6K9 Q9Y6K9
4	O88522 P62988
5	O88522 Q96EP0
6	Q9Y6K9 P0CG47 P0CG47
7	O88522 Q96C32 Q96C32
8	Q9Y6K9 Q9Y6K9 P0CG47 P0CG47

Downdload

Molecule viewer

Only interaction residues

#binding
partners

	4
	3
	2
	1
	0

Sequence information

1

GPLGSPEFGM

QLEDLKQQLQ

QAEEALVAKQ

EVIDKLKEEA

EQHKIVMETV

50

51

PVLKAQADIY

KADFQAERQA

REKLAEKKEL

LQEQLEQLQR

EYSKLKAS

100

Variants

	Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
	288_ALA	GLY	VAR_011322 rs137853330	LP/P	-	0.293	Ectodermal dysplasia and immunodeficiency 1 (EDAID1) [MIM:300291]
	311_ASP	ASN	VAR_011323 rs179363867	LP/P	-	0.9818	Ectodermal dysplasia and immunodeficiency 1 (EDAID1) [MIM:300291]
	314_ALA	PRO	VAR_072606 -	LP/P	-	0.9969	Incontinentia pigmenti (IP) [MIM:308300]
	315_GLU	ALA	VAR_031959 rs137853331	LP/P	-	0.9527	Immunodeficiency 33 (IMD33) [MIM:300636]
	319_ARG	GLN	VAR_031960 rs137853332	LP/P	-	0.7398	Immunodeficiency 33 (IMD33) [MIM:300636]
	322_LEU	PRO	VAR_072607 -	LP/P	-	0.9914	Incontinentia pigmenti (IP) [MIM:308300]
	323_ALA	PRO	VAR_042666 rs179363865	LP/P	-	0.9631	Incontinentia pigmenti (IP) [MIM:308300]

(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364