PDB ID 6RV6     CHAIN B
Protein name Properdin
Uniprot Accession P27918
The number of similar proteins 7
The number of binding states 4
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
6RV6 (CHAIN: B)
1 P27918  
2 P27918   7B26  
3 P27918   P01024  
4 7NOZ   P00751   P27918   P01024  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GVAGGWGPWG   PVSPCPVTCG   LGQTMEQRTC   NHPVPQHGGP   FCAGDATRTH   50
51   ICNTAVPCPV   DGEWDSWGEW   SPCIRRNMKS   ISCQEIPGQQ   SRGRTCRGRK   100
101   FDGHRCAGQQ   QDIRHCYSIQ   HCPLKGSWSE   WSTWGLCMPP   CGPNPTRARQ   150
151   RLCTPLLPKY   PPTVSMVEGQ   GEKNVTFWGR   PLPRCEELQG   QKLVVEEKRP   200
201   CLHVPACKDP   EEEELENLYF   Q       250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
297_ALA THR 8.3kJPN
chrX:47486223 		rs1454731911
- 0.0002 -
298_GLY VAL VAR_013139 rs28935480
LP/P - Properdin deficiency (PFD) [MIM:312060]
298_GLY VAL ClinVar
chrX:47486219 		rs28935480
Pathogenic - Properdin deficiency, X-linked [MONDO:MONDO:0010713,MedGen:C1839454,OMIM:312060,Orphanet:2966]
299_ASP ASN gnomAD
chrX:47486217 		rs61737993
- 0.00136078 -
321_TRP GLY ClinVar
chrX:47485898 		rs1603083173
Pathogenic - not provided [MedGen:C3661900]
343_GLN ARG VAR_002003 -
LP/P - Properdin deficiency (PFD) [MIM:312060]
403_ARG HIS 8.3kJPN
chrX:47485493 		rs1445510980
- 0.0001 -
414_TYR ASP VAR_002004 rs132630261
LP/P - Properdin deficiency (PFD) [MIM:312060]
414_TYR ASP ClinVar
chrX:47485461 		rs132630261
Pathogenic - Properdin deficiency, type III [MedGen:C1839456]
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.