PDB ID 4Z2M     CHAIN B
Protein name FACT complex subunit SPT16
Uniprot Accession Q9Y5B9
The number of similar proteins 5
The number of binding states 4
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4Z2M (CHAIN: B)
1 P62805   P62805   P68431   P68431  
2 Monomeric state
3 P0C1H3   P62805   P62805   P68431   P68431   P49736  
4 P62805   P62805   P68431   P68431   P49736   P20671   Q16778  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   GIVKQDSLVI   NLNRSNPKLK   DLYIRPNIAQ   KRMQGSLEAH   VNGFRFTSVR   50
51   GDKVDILYNN   IKHALFQPCD   GEMIIVLHFH   LKNAIMFGKK   RHTDVQFYTE   100
101   VGEITTDLGK   HQHMHDRDDL   YAEQMEREMR   HKLKTAFKNF   IEKVEALTKE   150
151   ELEFEVPFRD   LGFNGAPYRS   TCLLQPTSSA   LVNATEWPPF   VVTLDEVELI   200
201   HFERVQFHLK   NFDMVIVYKD   YSKKVTMINA   IPVASLDPIK   EWLNSCDLKY   250
251   TEGVQSLNWT   KIMKTIVDDP   EGFFEQGGWS   FLEPEGE     300

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
654_ASN SER 8.3kJPN
chr14:21829100
rs762249289
- 0.0001 0.1165 -
676_MET VAL 8.3kJPN
chr14:21829035
-
- 0.0001 0.6125 -
693_ARG GLN ClinVar
chr14:21828671
rs1886529007
Pathogenic - 0.9885 not provided [MedGen:C3661900]
693_ARG TER ClinVar
chr14:21828672
rs2503025907
Likely pathogenic - - Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum [MONDO:MONDO:0859179,MedGen:C5551361,OMIM:619480]
704_ILE VAL 8.3kJPN
chr14:21828639
-
- 0.0001 0.1094 -
734_ARG TRP VAR_086188
rs2139399670
US - 0.9721 Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum (NEDDFAC) [MIM:619480]
734_ARG TRP ClinVar
chr14:21827744
rs2139399670
Likely pathogenic - 0.9721 Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum [MONDO:MONDO:0859179,MedGen:C5551361,OMIM:619480]
847_ARG TRP ClinVar
chr14:21825477
rs2139397506
Pathogenic - 0.9991 Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum [MONDO:MONDO:0859179,MedGen:C5551361,OMIM:619480]
859_ILE VAL 8.3kJPN
chr14:21825441
-
- 0.0002 0.1004 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.