PDB ID 4QRS     CHAIN B
Protein name Beta-2-microglobulin
Uniprot Accession P61769
The number of similar proteins 1326
The number of binding states 30
The number of binding partners 15

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MGQRTPKIQV   YSRHPAENGK   SNFLNCYVSG   FHPSDIEVDL   LKNGERIEKV   50
51   EHSDLSFSKD   WSFYLLYYTE   FTPTEKDEYA   CRVNHVTLSQ   PKIVKWDRDM   100

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
33_SER PRO 8.3kJPN
chr15:45007710
-
- 0.0001 0.1026 -
44_GLU ASP 8.3kJPN
chr15:45007745
-
- 0.0001 0.1886 -
76_ASP ASN VAR_076691
rs398122820
LP/P - 0.4906 Amyloidosis, hereditary systemic 6 (AMYLD6) [MIM:620659]
76_ASP ASN ClinVar
chr15:45007839
rs398122820
Pathogenic - 0.4906 Familial visceral amyloidosis, Ostertag type|Non-Hodgkin lymphoma [MONDO:MONDO:0007099,MedGen:C0268389,OMIM:105200,Orphanet:85450|Human Phenotype Ontology:HP:0012539,MONDO:MONDO:0018908,MedGen:C0024305,Orphanet:547]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.