| PDB ID | 4GDK
|
CHAIN | B |
|---|---|---|---|
| Protein name | Autophagy protein 5 | ||
| Uniprot Accession | Q9H1Y0 | ||
| The number of similar proteins | 11 | ||
| The number of binding states | 7 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 4GDK (CHAIN: B) | |
| 1 |
Q676U5
Q676U5
O94817
|
| 2 | Monomeric state |
| 3 |
Q676U5
|
| 4 |
Q7Z6L1
|
| 5 |
Q676U5
|
| 6 |
Q676U5
O94817
|
| 7 |
Q676U5
Q676U5
|
Downdload
Molecule viewer
|
Only interaction residues |
|
||||||||||||
|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 58_LYS | MET |
VAR_036243
- |
US | - | 0.7761 | A colorectal cancer sample | |
| 65_ILE | VAL |
gnomAD chr6:106756282 rs77859116 |
- | 0.00342157 | 0.0516 | - | |
| 65_ILE | VAL |
8.3kJPN chr6:106756282 rs77859116 |
- | 0.0459 | 0.0516 | - | |
| 83_ILE | VAL |
8.3kJPN chr6:106740971 rs992870714 |
- | 0.0001 | 0.0563 | - | |
| 93_SER | ARG |
8.3kJPN chr6:106740939 - |
- | 0.0001 | 0.3198 | - | |
| 122_GLU | ASP |
VAR_079274
rs1131692265 |
LP/P | - | 0.92 | Spinocerebellar ataxia, autosomal recessive, 25 (SCAR25) [MIM:617584] | |
| 122_GLU | ASP |
ClinVar chr6:106727648 rs1131692265 |
Pathogenic | - | 0.92 | Spinocerebellar ataxia, autosomal recessive 25 [MONDO:MONDO:0033115,MedGen:C4539808,OMIM:617584] | |
| 129_MET | VAL |
gnomAD chr6:106727629 rs34793250 |
- | 0.000751668 | 0.0479 | - | |
| 141_VAL | ILE |
8.3kJPN chr6:106727593 rs765419687 |
- | 0.0007 | 0.0899 | - | |
| 167_ALA | SER |
8.3kJPN chr6:106696099 rs376999465 |
- | 0.0001 | 0.146 | - |