PDB ID 2A73     CHAIN B
Protein name Complement C3
Uniprot Accession P01024
The number of similar proteins 25
The number of binding states 12
The number of binding partners 13

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2A73 (CHAIN: B)
1 P01024  
2 P01024   6RU5  
3 P01024   2WII  
4 P01024   Q9Y279  
5 P01024   P00751  
6 P01024   P15529  
7 P01024   3G6J   3G6J  
8 P01024   P00751   P27918  
9 P01024   P08603   P05156   P05156  
10 P01024   P01024   P01024   P11215  
11 P01024   2WIN   2WIN   P00751   P00751  
12 P01024   P01024   P01024   P11215   P11215  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   VQLTEKRMDK   VGKYPKELRK   CCEDGMRENP   MRFSCQRRTR   FISLGEACKK   50
51   VFLDCCNYIT   ELRRQHARAS   HLGLARSNLD   EDIIAEENIV   SRSEFPESWL   100
101   WNVEDLKEPP   KNGISTKLMN   IFLKDSITTW   EILAVSMSDK   KGICVADPFE   150
151   VTVMQDFFID   LRLPYSVVRN   EQVEIRAVLY   NYRQNQELKV   RVELLHNPAF   200
201   CSLATTKRRH   QQTVTIPPKS   SLSVPYVIVP   LKTGLQEVEV   KAAVYHHFIS   250
251   DGVRKSLKVV   PEGIRMNKTV   AVRTLDPERL   GREGVQKEDI   PPADLSDQVP   300
301   DTESETRILL   QGTPVAQMTE   DAVDAERLKH   LIVTPSGCGE   QNMIGMTPTV   350
351   IAVHYLDETE   QWEKFGLEKR   QGALELIKKG   YTQQLAFRQP   SSAFAAFVKR   400
401   APSTWLTAYV   VKVFSLAVNL   IAIDSQVLCG   AVKWLILEKQ   KPDGVFQEDA   450
451   PVIHQEMIGG   LRNNNEKDMA   LTAFVLISLQ   EAKDICEEQV   NSLPGSITKA   500
501   GDFLEANYMN   LQRSYTVAIA   GYALAQMGRL   KGPLLNKFLT   TAKDKNRWED   550
551   PGKQLYNVEA   TSYALLALLQ   LKDFDFVPPV   VRWLNEQRYY   GGGYGSTQAT   600
601   FMVFQALAQY   QKDAPDHQEL   NLDVSLQLPS   RSSKITHRIH   WESASLLRSE   650
651   ETKENEGFTV   TAEGKGQGTL   SVVTMYHAKA   KDQLTCNKFD   LKVTIKPAPE   700
701   TEKRPQDAKN   TMILEICTRY   RGDQDATMSI   LDISMMTGFA   PDTDDLKQLA   750
751   NGVDRYISKY   ELDKAFSDRN   TLIIYLDKVS   HSEDDCLAFK   VHQYFNVELI   800
801   QPGAVKVYAY   YNLEESCTRF   YHPEKEDGKL   NKLCRDELCR   CAEENCFIQK   850
851   SDDKVTLEER   LDKACEPGVD   YVYKTRLVKV   QLSNDFDEYI   MAIEQTIKSG   900
901   SDEVQVGQQR   TFISPIKCRE   ALKLEEKKHY   LMWGLSSDFW   GEKPNLSYII   950
951   GKDTWVEHWP   EEDECQDEEN   QKQCQDLGAF   TESMVVFGCP   N   1000

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
651_VAL MET 8.3kJPN
chr19:6707507 		rs534845907
- 0.0001 -
665_PRO THR 8.3kJPN
chr19:6707273 		-
- 0.0001 -
690_ARG HIS 8.3kJPN
chr19:6707197 		rs773113880
- 0.0005 -
690_ARG CYS 8.3kJPN
chr19:6707198 		rs763061857
- 0.0001 -
713_ARG TRP VAR_063215 rs117793540
LP/P - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
713_ARG TRP gnomAD
chr19:6707129 		rs117793540
- 0.00218304 -
713_ARG TRP 8.3kJPN
chr19:6707129 		rs117793540
- 0.0001 -
714_ARG GLN 8.3kJPN
chr19:6707125 		rs578116271
- 0.0005 -
715_GLN TER ClinVar
chr19:6707123 		-
Pathogenic - not provided [MedGen:C3661900]
718_ARG TRP 8.3kJPN
chr19:6707114 		rs945676974
- 0.0001 -
742_ARG TER ClinVar
chr19:6702546 		-
Pathogenic - not provided [MedGen:C3661900]
743_SER THR 8.3kJPN
chr19:6702542 		-
- 0.0005 -
753_VAL ALA 8.3kJPN
chr19:6702512 		-
- 0.0001 -
793_ILE MET 8.3kJPN
chr19:6697801 		-
- 0.0001 -
800_GLU LYS 8.3kJPN
chr19:6697782 		-
- 0.0001 -
805_GLN TER ClinVar
chr19:6697767 		-
Pathogenic - not provided [MedGen:C3661900]
807_PHE LEU 8.3kJPN
chr19:6697759 		-
- 0.0001 -
822_GLN ARG ClinVar
chr19:6697715 		rs1599510478
Likely pathogenic - Atypical hemolytic-uremic syndrome with C3 anomaly [MONDO:MONDO:0013043,MedGen:C2752037,OMIM:612925,Orphanet:2134]
841_ARG LYS VAR_019206 rs11569472
LB/B - -
849_ALA GLY 8.3kJPN
chr19:6697539 		-
- 0.0001 -
864_VAL ILE 8.3kJPN
chr19:6697495 		rs149395057
- 0.0003 -
868_PRO ARG 8.3kJPN
chr19:6697482 		rs753876258
- 0.0001 -
877_VAL ILE 8.3kJPN
chr19:6697456 		-
- 0.0001 -
878_ILE MET 8.3kJPN
chr19:6697451 		rs763155610
- 0.0021 -
890_VAL LEU 8.3kJPN
chr19:6697417 		-
- 0.0001 -
908_LYS ASN 8.3kJPN
chr19:6697361 		-
- 0.0001 -
967_GLN TER ClinVar
chr19:6694631 		-
Pathogenic - not provided [MedGen:C3661900]
991_GLN HIS 8.3kJPN
chr19:6694557 		-
- 0.0001 -
995_GLY CYS 8.3kJPN
chr19:6694547 		-
- 0.0003 -
1007_ASP ASN ClinVar
chr19:6694511 		rs1599507415
Likely pathogenic - Mesangiocapillary glomerulonephritis [Human Phenotype Ontology:HP:0000793,MONDO:MONDO:0002461,MedGen:C0017662]
1020_ARG LEU VAR_063655 -
LP/P - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1072_ALA VAL VAR_063216 rs121909584
LP/P - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1079_CYS TRP ClinVar
chr19:6693022 		rs1236557685
Likely pathogenic - not provided [MedGen:C3661900]
1093_ASP ASN VAR_063217 rs121909585
LP/P - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1122_THR ALA 8.3kJPN
chr19:6690699 		-
- 0.0001 -
1135_ILE THR ClinVar
chr19:6690659 		rs1918142335
Pathogenic - Atypical hemolytic-uremic syndrome [MONDO:MONDO:0016244,MedGen:C2931788,Orphanet:2134]
1136_CYS TRP VAR_063218 -
LP/P - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1139_GLN LYS VAR_063219 -
LP/P - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1202_GLY ASP VAR_019207 rs11569534
LB/B - -
1202_GLY ASP gnomAD
chr19:6686274 		rs11569534
- 0.00147915 -
1230_VAL ILE gnomAD
chr19:6686191 		rs537300095
- 0.000258453 -
1230_VAL ILE 8.3kJPN
chr19:6686191 		rs537300095
- 0.0001 -
1241_GLY ALA 8.3kJPN
chr19:6686157 		-
- 0.0001 -
1249_ALA SER 8.3kJPN
chr19:6685157 		-
- 0.0001 -
1264_ALA THR 8.3kJPN
chr19:6685112 		rs556995881
- 0.0001 -
1281_ARG HIS ClinVar
chr19:6685060 		rs775015499
Likely pathogenic - Atypical hemolytic-uremic syndrome with C3 anomaly [MONDO:MONDO:0013043,MedGen:C2752037,OMIM:612925,Orphanet:2134]
1281_ARG CYS 8.3kJPN
chr19:6685061 		rs567359713
- 0.0001 -
1286_THR ILE 8.3kJPN
chr19:6685045 		-
- 0.0001 -
1345_ILE THR VAR_019208 rs11569541
LB/B - -
1345_ILE THR gnomAD
chr19:6684591 		rs11569541
- 0.000628241 -
1359_LYS ARG 8.3kJPN
chr19:6684429 		rs1232402436
- 0.0001 -
1361_THR ASN gnomAD
chr19:6684423 		rs139100972
- 0.000151096 -
1371_ARG GLN 8.3kJPN
chr19:6682235 		rs575119407
- 0.0005 -
1371_ARG TRP 8.3kJPN
chr19:6682236 		rs148227405
- 0.0001 -
1372_GLY ARG 8.3kJPN
chr19:6682233 		rs200597513
- 0.0001 -
1378_MET VAL 8.3kJPN
chr19:6682215 		-
- 0.0001 -
1418_ASP ALA gnomAD
chr19:6681983 		rs147116781
- 0.000258453 -
1418_ASP ASN 8.3kJPN
chr19:6681984 		rs772034590
- 0.0001 -
1435_ASP HIS gnomAD
chr19:6680256 		rs113742728
- 0.000278352 -
1442_HIS ASP VAR_063220 -
LP/P - Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1459_ALA THR 8.3kJPN
chr19:6680184 		rs1293706769
- 0.0001 -
1462_ASN SER 8.3kJPN
chr19:6680174 		-
- 0.0001 -
1473_PRO ALA 8.3kJPN
chr19:6679481 		-
- 0.0002 -
1490_ARG CYS ClinVar
chr19:6679430 		rs1408701335
Likely pathogenic - Atypical hemolytic-uremic syndrome with C3 anomaly [MONDO:MONDO:0013043,MedGen:C2752037,OMIM:612925,Orphanet:2134]
1490_ARG HIS gnomAD
chr19:6679429 		rs142868256
- 0.000111343 -
1499_GLN ARG VAR_029792 rs7256789
LB/B - -
1527_LEU MET gnomAD
chr19:6678452 		rs149202905
- 0.000981862 -
1579_HIS ASN VAR_029793 rs1803225
LB/B - -
1582_MET THR 8.3kJPN
chr19:6678202 		rs761512303
- 0.0004 -
1597_SER ARG VAR_029326 rs2230210
LB/B - -
1597_SER ARG gnomAD
chr19:6678030 		rs2230210
- 0.00118499 -
1602_LYS TER ClinVar
chr19:6678015 		-
Likely pathogenic - not provided [MedGen:C3661900]
1604_THR SER 8.3kJPN
chr19:6678008 		rs1386293935
- 0.0001 -
1607_GLU ASP 8.3kJPN
chr19:6677998 		rs200816772
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.