PDB ID 1Z2C     CHAIN B
Protein name Diaphanous protein homolog 1
Uniprot Accession O08808
The number of similar proteins 10
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1Z2C (CHAIN: B)
1 P08134  
2 O08808  
3 O08808  
4 O08808   P60766  
5 O08808   O08808  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   DPTAQSLQDI   SDEQVLVLFE   QMLVDMNLNE   EKQQPLREKD   IVIKREMVSQ   50
51   YLHTSKAGMN   QKESSRSAMM   YIQELRSGLR   DMHLLSCLES   LRVSLNNNPV   100
101   SWVQTFGAEG   LASLLDILKR   LHDEKEETSG   NYDSRNQHEI   IRCLKAFMNN   150
151   KFGIKTMLET   EEGILLLVRA   MDPAVPNMMI   DAAKLLSALC   ILPQPEDMNE   200
201   RVLEAMTERA   EMDEVERFQP   LLDGLKSGTS   IALKVGCLQL   INALITPAEE   250
251   LDFRVHIRSE   LMRLGLHQVL   QELREIENED   MKVQLCVFDE   QGDEDFFDLK   300
301   GRLDDIRMEM   DDFGEVFQII   LNTVKDSKAE   PHFLSILQHL   LLVRNDYEAR   350
351   PQYYKLIEEC   VSQIVLHKNG   TDPDFKCRHL   QID     400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
160_ARG CYS 8.3kJPN
chr5:140963080 		-
- 0.0001 -
291_ASP ALA 8.3kJPN
chr5:140958689 		-
- 0.0001 -
303_VAL ILE 8.3kJPN
chr5:140958192 		-
- 0.0001 -
338_LEU SER 8.3kJPN
chr5:140958086 		-
- 0.0001 -
342_ARG TER ClinVar
chr5:140957904 		-
Pathogenic - Autosomal dominant nonsyndromic hearing loss 1 [MONDO:MONDO:0007424,MedGen:C1852282,OMIM:124900,Orphanet:90635]; Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome [MONDO:MONDO:0014714,MedGen:C5567650,OMIM:616632,Orphanet:477814]
419_PRO HIS 8.3kJPN
chr5:140956436 		rs1339899658
- 0.0001 -
429_ILE VAL 8.3kJPN
chr5:140956407 		-
- 0.0001 -
434_LEU MET 8.3kJPN
chr5:140956392 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.