PiSITE

PDB ID	1X79	CHAIN	B
Protein name	Rab GTPase binding effector protein 1
Uniprot Accession	Q15276
The number of similar proteins	10
The number of binding states	5
The number of binding partners	4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1X79 (CHAIN: B)
1	Q15276 Q9UJY5
2	Q15276 Q9UJ41
3	Q15276 Q9UJ41
4	Q15276 Q15276 Q15276 Q9UJ41
5	Q15276 Q15276 Q15276 Q9UJ41 Q9UJ41

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Molecule viewer

Only interaction residues

#binding
partners

	3
	2
	1
	0

Sequence information

1

MAETRDQVKK

LQLMLRQAND

QLEKTMKDKQ

ELEDFIKQSS

EDSSHQISAL

50

51

VLRAQASEIL

LEELQQGLSQ

AKRDVQEQMA

VLMQSREQVS

EELVRLQKDN

100

101

DSLQGKHSLH

VS

150

Variants

	Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
	553_THR	MET	gnomAD chr17:5266301 rs374594228	-	0.00142677	0.0979	-
	588_SER	ASN	8.3kJPN chr17:5268511 -	-	0.0001	0.0876	-
	628_MET	ILE	8.3kJPN chr17:5271763 rs61735455	-	0.0001	0.6287	-
	640_GLU	GLY	VAR_028106 rs3026099	LB/B	-	0.1195	-
	640_GLU	GLY	gnomAD chr17:5276643 rs3026099	-	0.0002969	0.1195	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364