PDB ID 1L3E     CHAIN B
Protein name p300 protein
Uniprot Accession Q09472
The number of similar proteins 9
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1L3E (CHAIN: B)
1 Q16665  
2 Monomeric state
3 Q99967  
4 P52630  
5 Q548Y4  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MGSGAHTADP   EKRKLIQQQL   VLLLHAHKCQ   RREQANGEVR   QCNLPHCRTM   50
51   KNVLNHMTHC   QSGKSCQVAH   CASSRQIISH   WKNCTRHDCP   VCLPLKNAGD   100
101   K           150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
117_GLN TER ClinVar
chr16:3843540
rs587783460
Pathogenic - - Rubinstein-Taybi syndrome due to CREBBP mutations [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783]
119_GLN TER ClinVar
chr16:3843534
rs121434625
Pathogenic - - Rubinstein-Taybi syndrome due to CREBBP mutations [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783]
127_HIS PRO ClinVar
chr16:3843509
-
Likely pathogenic - 0.9996 Rubinstein-Taybi syndrome due to CREBBP mutations [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783]
129_CYS PHE ClinVar
chr16:3843503
rs1057518498
Likely pathogenic - 0.9998 not provided [MedGen:CN517202]
132_ARG TER ClinVar
chr16:3843495
rs1384496494
Pathogenic - - Rubinstein-Taybi syndrome due to CREBBP mutations|Corpus callosum, agenesis of [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783|Human Phenotype Ontology:HP:0001274,Human Phenotype Ontology:HP:0006800,MONDO:MONDO:0009022,MedGen:C0175754,OMIM:217990,Orphanet:200]
134_GLN TER ClinVar
chr22:41523650
rs1555907278
Pathogenic - - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
142_CYS TER ClinVar
chr22:41523676
rs786205557
Likely pathogenic - - not provided [MedGen:C3661900]
148_ARG TER ClinVar
chr16:3843447
rs587783461
Pathogenic - - Rubinstein-Taybi syndrome due to CREBBP mutations [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783]
166_CYS TER ClinVar
chr22:41523748
rs1555907286
Likely pathogenic - - not provided [MedGen:C3661900]
169_ALA SER 8.3kJPN
chr22:41525896
-
- 0.0001 0.6601 -
175_ARG TER ClinVar
chr16:3842075
rs1302427305
Pathogenic - - Rubinstein-Taybi syndrome due to CREBBP mutations|not provided [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783|MedGen:CN517202]
181_TRP TER ClinVar
chr16:3842055
rs587783463
Pathogenic - - Rubinstein-Taybi syndrome due to CREBBP mutations [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783]
185_THR ALA 8.3kJPN
chr16:3842045
-
- 0.0001 0.7673 -
186_ARG TER ClinVar
chr16:3842042
rs587783464
Pathogenic - - Rubinstein-Taybi syndrome due to CREBBP mutations|not provided [MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783|MedGen:CN517202]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.