| PDB ID | 1IAR
|
CHAIN | B |
|---|---|---|---|
| Protein name | PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN) | ||
| Uniprot Accession | P24394 | ||
| The number of similar proteins | 7 | ||
| The number of binding states | 6 | ||
| The number of binding partners | 6 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1IAR (CHAIN: B) | |
| 1 |
P05112
|
| 2 |
6WGL
6WGL
|
| 3 |
P78552
P35225
|
| 4 |
P05112
P78552
|
| 5 |
P05112
P31785
|
| 6 |
P05112
6OEL
6OEL
P31785
|
Downdload
Molecule viewer
|
Only interaction residues |
|
||||||||||||||
|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 10_VAL | ILE |
8.3kJPN chr16:27353474 rs372988882 |
- | 0.0001 | 0.0823 | - | |
| 18_THR | ALA |
8.3kJPN chr16:27353498 rs749110570 |
- | 0.0005 | 0.1573 | - | |
| 28_ASN | SER |
gnomAD chr16:27353529 rs201852059 |
- | 0.000163047 | 0.1194 | - | |
| 28_ASN | ILE |
8.3kJPN chr16:27353529 rs201852059 |
- | - | 0.5198 | - | |
| 34_ARG | CYS |
8.3kJPN chr16:27353546 rs191774649 |
- | 0.0013 | 0.1764 | - | |
| 40_VAL | PHE |
gnomAD chr16:27353564 rs555743307 |
- | 0.000286353 | 0.1485 | - | |
| 44_SER | PHE |
8.3kJPN chr16:27353577 - |
- | 0.0001 | 0.289 | - | |
| 50_ILE | VAL |
VAR_008034
rs1805010 |
LB/B | - | 0.0687 | - | |
| 50_ILE | PHE |
VAR_059302
rs1805010 |
LB/B | - | 0.1731 | - | |
| 50_ILE | LEU |
VAR_059303
rs1805010 |
LB/B | - | 0.1729 | - | |
| 50_ILE | VAL |
gnomAD chr16:27356203 rs1805010 |
- | 0.447775 | 0.0687 | - | |
| 50_ILE | VAL |
8.3kJPN chr16:27356203 rs1805010 |
- | 0.6196 | 0.0687 | - | |
| 57_ALA | THR |
gnomAD chr16:27356224 rs144651842 |
- | 0.0127006 | 0.0678 | - | |
| 57_ALA | THR |
8.3kJPN chr16:27356224 rs144651842 |
- | 0.0652 | 0.0678 | - | |
| 60_VAL | MET |
gnomAD chr16:27356233 rs141983833 |
- | 0.000202953 | 0.1305 | - | |
| 89_SER | PHE |
gnomAD chr16:27356321 rs543167942 |
- | 0.000171399 | 0.1424 | - | |
| 90_PHE | ILE |
gnomAD chr16:27356323 rs199703000 |
- | 0.000685652 | 0.8888 | - | |
| 91_LYS | ASN |
8.3kJPN chr16:27356328 - |
- | 0.0001 | 0.7717 | - | |
| 94_GLU | LYS |
gnomAD chr16:27356335 rs141903283 |
- | 0.000299578 | 0.1518 | - | |
| 95_HIS | ARG |
8.3kJPN chr16:27356339 - |
- | 0.0001 | 0.1904 | - | |
| 133_THR | SER |
8.3kJPN chr16:27357898 - |
- | 0.0001 | 0.1503 | - | |
| 143_ASP | ASN |
8.3kJPN chr16:27357928 rs568385218 |
- | 0.001 | 0.1205 | - | |
| 143_ASP | GLU |
8.3kJPN chr16:27357930 rs775265328 |
- | 0.0001 | 0.3657 | - | |
| 144_PRO | LEU |
gnomAD chr16:27357932 rs145473866 |
- | 0.000107464 | 0.1486 | - | |
| 160_ARG | HIS |
gnomAD chr16:27363901 rs150955128 |
- | 0.0149458 | 0.1087 | - | |
| 160_ARG | HIS |
8.3kJPN chr16:27363901 rs150955128 |
- | 0.0035 | 0.1087 | - | |
| 175_ARG | TRP |
8.3kJPN chr16:27363945 rs370524692 |
- | 0.0001 | 0.4168 | - | |
| 175_ARG | GLN |
8.3kJPN chr16:27363946 rs147547377 |
- | 0.0047 | 0.1086 | - |