PDB ID 1I3Q     CHAIN B
Protein name DNA-DIRECTED RNA POLYMERASE II 140KD POLYPEPTIDE
Uniprot Accession P08518
The number of similar proteins 147
The number of binding states 15
The number of binding partners 13

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1I3Q (CHAIN: B)
1 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P20434  
2 P16370   P04050  
3 P40422   P38902   P22139   P27999   P20435   P16370   P04050  
4 P40422   P38902   P22139   P27999   P16370   P04050   P20436  
5 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P20436  
6 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P29055  
7 A0A6A5PY05   A0A6A5Q7A1   A0A6A5Q7Q6   A0A7I9EWC2   A0A6A5Q0Z3   P04050   A0A6A5Q270   A0A6A5Q456  
8 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P20434   P07273  
9 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P34087   P20433  
10 A0A6A5PY05   A0A6A5Q7A1   A0A6A5Q7Q6   A0A7I9EWC2   P20435   A0A6A5Q0Z3   P04050   A0A6A5Q270   A0A6A5Q456  
11 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P34087   P20434   P20433  
12 A0A6A5PY05   A0A6A5Q7A1   A0A6A5Q7Q6   A0A7I9EWC2   P20435   A0A6A5Q0Z3   P04050   A0A6A5Q8C2   A0A6A5Q270   A0A6A5Q456  
13 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P34087   P20434   P20433   P07273  
14 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P20436   P34087   P20434   P20433  
15 P40422   P38902   P22139   P27999   P20435   P16370   P04050   P34087   P20434   P20433   P29055  

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Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MSDLANSEKY   YDEDPYGFED   ESAPITAEDS   WAVISAFFRE   KGLVSQQLDS   50
51   FNQFVDYTLQ   DIICEDSTLI   LEQLAQHTTE   SDNISRKYEI   SFGKIYVTKP   100
101   MVNESDGVTH   ALYPQEARLR   NLTYSSGLFV   DVKKRTYEAI   DVPGRELKYE   150
151   LIAEESEDDS   ESGKVFIGRL   PIMLRSKNCY   LSEATESDLY   KLKECPFDMG   200
201   GYFIINGSEK   VLIAQERSAG   NIVQVFKKAA   PSPISHVAEI   RSALEKGSRF   250
251   ISTLQVKLYG   REGSSARTIK   ATLPYIKQDI   PIVIIFRALG   IIPDGEILEH   300
301   ICYDVNDWQM   LEMLKPCVED   GFVIQDRETA   LDFIGRRGTA   LGIKKEKRIQ   350
351   YAKDILQKEF   LPHITQLEGF   ESRKAFFLGY   MINRLLLCAL   DRKDQDDRDH   400
401   FGKKRLDLAG   PLLAQLFKTL   FKKLTKDIFR   YMQRTVEEAH   DFNMKLAINA   450
451   KTITSGLKYA   LATGNWGEQK   KAMSSRAGVS   QVLNRYTYSS   TLSHLRRTNT   500
501   PIGRDGKLAK   PRQLHNTHWG   LVCPAETPEG   QACGLVKNLS   LMSCISVGTD   550
551   PMPIITFLSE   WGMEPLEDYV   PHQSPDATRV   FVNGVWHGVH   RNPARLMETL   600
601   RTLRRKGDIN   PEVSMIRDIR   EKELKIFTDA   GRVYRPLFIV   EDDESLGHKE   650
651   LKVRKGHIAK   LMATEYQDIE   GGFEDVEEYT   WSSLLNEGLV   EYIDAEEEES   700
701   ILIAMQPEDL   EPAEANEEND   LDVDPAKRIR   VSHHATTFTH   CEIHPSMILG   750
751   VAASIIPFPD   HNQSPRNTYQ   SAMGKQAMGV   FLTNYNVRMD   TMANILYYPQ   800
801   KPLGTTRAME   YLKFRELPAG   QNAIVAIACY   SGYNQEDSMI   MNQSSIDRGL   850
851   FRSLFFRSYM   DQEKKYGMSI   TETFEKPQRT   NTLRMKHGTY   DKLDDDGLIA   900
901   PGVRVSGEDV   IIGKTTPISP   DEEELGQRTA   YHSKRDASTP   LRSTENGIVD   950
951   QVLVTTNQDG   LKFVKVRVRT   TKIPQIGDKF   ASRHGQKGTI   GITYRREDMP   1000
1001   FTAEGIVPDL   IINPHAIPSR   MTVAHLIECL   LSKVAALSGN   EGDASPFTDI   1050
1051   TVEGISKLLR   EHGYQSRGFE   VMYNGHTGKK   LMAQIFFGPT   YYQRLRHMVD   1100
1101   DKIHARARGP   MQVLTRQPVE   GRSRDGGLRF   GEMERDCMIA   HGAASFLKER   1150
1151   LMEASDAFRV   HICGICGLMT   VIAKLNHNQF   ECKGCDNKID   IYQIHIPYAA   1200
1201   KLLFQELMAM   NITPRLYTDR   SRDF       1250

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

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