| PDB ID | 1GZR
|
CHAIN | B |
|---|---|---|---|
| Protein name | INSULIN-LIKE GROWTH FACTOR I | ||
| Uniprot Accession | P01343 | ||
| The number of similar proteins | 19 | ||
| The number of binding states | 6 | ||
| The number of binding partners | 5 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1GZR (CHAIN: B) | |
| 1 | Monomeric state |
| 2 |
P24593
|
| 3 |
P06213
|
| 4 |
P08069
|
| 5 |
Q09024
|
| 6 |
P08833
P22692
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 19_GLY | GLU |
8.3kJPN chr12:102869441 - |
- | 0.0001 | - | - | |
| 28_PRO | HIS |
8.3kJPN chr12:102813462 - |
- | 0.0001 | - | - | |
| 47_CYS | TER |
ClinVar chr12:102813404 rs3730193 |
Likely pathogenic | - | - | Growth delay due to insulin-like growth factor type 1 deficiency [MONDO:MONDO:0012110,MedGen:C1837475,OMIM:608747,Orphanet:73272] | |
| 61_CYS | TER |
ClinVar chr12:102813362 - |
Pathogenic | - | - | Monogenic short statue [-] | |
| 63_PRO | THR |
8.3kJPN chr12:102813358 - |
- | 0.0001 | - | - |