PiSITE

PDB ID	1GFW	CHAIN	B
Protein name	CASPASE-3 (APOPAIN, P10)
Uniprot Accession	P42574
The number of similar proteins	96
The number of binding states	4
The number of binding partners	4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1GFW (CHAIN: B)
1	P42574
2	P42574 2XZT
3	P42574 P42574 P42574
4	P42574 P42574 P42574 P98170 P98170

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Molecule viewer

Only interaction residues

#binding
partners

	3
	2
	1
	0

Sequence information

1

DMACHKIPVD

ADFLYAYSTA

PGYYSWRNSK

DGSWFIQSLC

AMLKQYADKL

50

51

EFMHILTRVN

RKVATEFESF

SFDATFHAKK

QIPCIVSMLT

KELYFYH

100

Variants

	Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
	186_LYS	ASN	8.3kJPN chr4:185552237 -	-	0.0001	0.8164	-
	217_GLN	HIS	8.3kJPN chr4:185550609 rs754910045	-	0.0001	0.943	-
	218_SER	LEU	gnomAD chr4:185550607 rs371145290	-	0.000123411	0.7949	-
	222_MET	ILE	8.3kJPN chr4:185550594 -	-	0.0001	0.5465	-
	254_ALA	THR	8.3kJPN chr4:185550500 rs1393598499	-	0.0001	0.0861	-
	270_THR	ARG	8.3kJPN chr4:185550451 -	-	0.0001	0.6328	-
	277_HIS	TYR	gnomAD chr4:185550431 rs147767351	-	0.000344055	0.1053	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364