| PDB ID | 1D5X
|
CHAIN | B |
|---|---|---|---|
| Protein name | HLA CLASS II HISTOCOMPATIBILITY ANTIGEN | ||
| Uniprot Accession | P13760 | ||
| The number of similar proteins | 129 | ||
| The number of binding states | 20 | ||
| The number of binding partners | 11 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1D5X (CHAIN: B) | |
| 1 |
P01903
|
| 2 |
P01903
|
| 3 |
P01903
8EUQ
|
| 4 |
P01903
4Y19
|
| 5 |
P01903
P01730
|
| 6 |
P01903
P28068
|
| 7 |
6R0E
P01903
|
| 8 |
P01903
Q48898
|
| 9 |
P01903
O85383
|
| 10 |
P01903
P03205
|
| 11 |
P01903
RWHUAC
S18894
|
| 12 |
P01903
3O6F
3O6F
|
| 13 |
A2BFX2
P01903
P01903
|
| 14 |
P04229
P01903
P01903
|
| 15 |
RWHUAC
P01850
P01903
|
| 16 |
29293741
P01850
P01903
|
| 17 |
6CQL
6CQL
P01903
|
| 18 |
4E41
4E41
P01903
|
| 19 |
4H1L
P01903
4H1L
|
| 20 |
P01903
3T0E
3T0E
P01730
|
Downdload
Molecule viewer
|
Only interaction residues |
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|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 1_GLY | ARG |
gnomAD chr6:32497914 rs76748970 |
- | 0.239628 | - | - | |
| 1_GLY | VAL |
8.3kJPN chr6:32497913 rs146966122 |
- | 0.0927 | - | - | |
| 1_GLY | ARG |
8.3kJPN chr6:32497914 rs76748970 |
- | 0.3082 | - | - | |
| 1_GLY | VAL |
8.3kJPN chr6:32557431 rs761074986 |
- | 0.0696 | - | - | |
| 2_ASP | ASN |
gnomAD chr6:32557429 rs372634318 |
- | 0.000413715 | - | - | |
| 2_ASP | GLY |
8.3kJPN chr6:32497910 rs139583918 |
- | 0.1119 | - | - | |
| 2_ASP | GLU |
8.3kJPN chr6:32557427 - |
- | 0.0001 | - | - | |
| 2_ASP | GLY |
8.3kJPN chr6:32557428 rs201700261 |
- | 0.1078 | - | - | |
| 3_THR | PRO |
8.3kJPN chr6:32497908 rs796754225 |
- | 0.0031 | - | - | |
| 3_THR | PRO |
8.3kJPN chr6:32557426 rs749376442 |
- | 0.0011 | - | - | |
| 4_ARG | GLY |
gnomAD chr6:32557423 rs9256943 |
- | 0.0522666 | - | - | |
| 4_ARG | GLN |
8.3kJPN chr6:32497904 rs1141741 |
- | 0.1696 | - | - | |
| 4_ARG | TER |
8.3kJPN chr6:32497905 rs71549219 |
- | - | - | - | |
| 4_ARG | GLN |
8.3kJPN chr6:32557422 rs17879746 |
- | 0.274 | - | - | |
| 5_PRO | SER |
8.3kJPN chr6:32557420 rs761045049 |
- | 0.0001 | - | - | |
| 6_ARG | CYS |
8.3kJPN chr6:32489949 rs1136744 |
- | 0.0124 | - | - | |
| 9_GLN | ARG |
gnomAD chr6:32489939 rs17433849 |
- | 0.000101551 | - | - | |
| 9_GLN | GLU |
gnomAD chr6:32489940 rs1071747 |
- | 0.0301896 | - | - | |
| 9_GLN | LYS |
gnomAD chr6:32489940 rs1071747 |
- | 0.0801815 | - | - | |
| 9_TRP | GLY |
gnomAD chr6:32552144 rs9269959 |
- | 0.0278498 | - | - | |
| 9_GLN | ARG |
8.3kJPN chr6:32489939 rs17433849 |
- | 0.0033 | - | - | |
| 9_GLN | TER |
8.3kJPN chr6:32489940 rs1071747 |
- | - | - | - | |
| 9_TRP | TER |
8.3kJPN chr6:32552143 rs9269958 |
- | 0.5107 | - | - | |
| 9_TRP | GLY |
8.3kJPN chr6:32552144 rs9269959 |
- | 0.4539 | - | - | |
| 10_GLN | LEU |
gnomAD chr6:32489936 rs201948867 |
- | 0.00139793 | - | - | |
| 10_GLN | LEU |
gnomAD chr6:32552140 rs17882663 |
- | 0.0184337 | - | - | |
| 10_GLN | LEU |
8.3kJPN chr6:32489936 rs201948867 |
- | 0.0661 | - | - | |
| 10_GLN | GLU |
8.3kJPN chr6:32489937 rs200071340 |
- | 0.0083 | - | - | |
| 10_GLN | LEU |
8.3kJPN chr6:32552140 rs17882663 |
- | 0.1363 | - | - | |
| 11_ASP | VAL |
gnomAD chr6:32489933 rs1071748 |
- | 0.00220524 | - | - | |
| 11_ASP | GLY |
gnomAD chr6:32489933 rs1071748 |
- | 0.000232851 | - | - | |
| 11_ASP | HIS |
gnomAD chr6:32489934 rs1136752 |
- | 0.00218949 | - | - | |
| 11_PRO | LEU |
gnomAD chr6:32552137 rs17878703 |
- | 0.0263411 | - | - | |
| 11_PRO | ARG |
gnomAD chr6:32552137 rs17878703 |
- | 0.000573792 | - | - | |
| 11_PRO | ALA |
gnomAD chr6:32552138 rs9269955 |
- | 0.00589531 | - | - | |
| 11_ASP | VAL |
8.3kJPN chr6:32489933 rs1071748 |
- | - | - | - | |
| 11_ASP | HIS |
8.3kJPN chr6:32489934 rs1136752 |
- | 0.0698 | - | - | |
| 11_PRO | LEU |
8.3kJPN chr6:32552137 rs17878703 |
- | - | - | - | |
| 11_PRO | SER |
8.3kJPN chr6:32552138 rs9269955 |
- | - | - | - | |
| 12_LYS | THR |
gnomAD chr6:32489930 rs200581589 |
- | 0.0371716 | - | - | |
| 12_LYS | THR |
gnomAD chr6:32552134 rs1136756 |
- | 0.186264 | - | - | |
| 12_LYS | THR |
8.3kJPN chr6:32489930 rs200581589 |
- | 0.0239 | - | - | |
| 12_LYS | THR |
8.3kJPN chr6:32552134 rs1136756 |
- | 0.293 | - | - | |
| 12_LYS | TER |
8.3kJPN chr6:32552135 rs766505678 |
- | 0.0011 | - | - | |
| 13_TYR | PHE |
gnomAD chr6:32489927 rs1136760 |
- | 0.0732127 | - | - | |
| 13_TYR | SER |
gnomAD chr6:32489927 rs1136760 |
- | 0.0473745 | - | - | |
| 13_TYR | HIS |
gnomAD chr6:32489928 rs1136757 |
- | 0.000154771 | - | - | |
| 13_ARG | SER |
gnomAD chr6:32552130 rs9269951 |
- | 0.293707 | - | - | |
| 13_ARG | MET |
gnomAD chr6:32552131 rs1136759 |
- | 0.00891459 | - | - | |
| 13_ARG | THR |
gnomAD chr6:32552131 rs1136759 |
- | 0.229957 | - | - | |
| 13_ARG | LYS |
gnomAD chr6:32552131 rs1136759 |
- | 0.000120467 | - | - | |
| 13_ARG | TRP |
gnomAD chr6:32552132 rs1136758 |
- | 0.247761 | - | - | |
| 13_ARG | GLY |
gnomAD chr6:32552132 rs1136758 |
- | 0.0272216 | - | - | |
| 13_TYR | PHE |
8.3kJPN chr6:32489927 rs1136760 |
- | - | - | - | |
| 13_TYR | HIS |
8.3kJPN chr6:32489928 rs1136757 |
- | 0.2337 | - | - | |
| 13_ARG | SER |
8.3kJPN chr6:32552130 rs9269951 |
- | 0.7669 | - | - | |
| 13_ARG | MET |
8.3kJPN chr6:32552131 rs1136759 |
- | - | - | - | |
| 13_ARG | TRP |
8.3kJPN chr6:32552132 rs1136758 |
- | - | - | - | |
| 14_GLU | LYS |
8.3kJPN chr6:32489925 rs17405212 |
- | 0.0027 | - | - | |
| 16_HIS | TYR |
gnomAD chr6:32489919 rs199680107 |
- | 0.0125183 | - | - | |
| 16_HIS | GLN |
gnomAD chr6:32552121 rs17879981 |
- | 0.000590411 | - | - | |
| 16_HIS | TYR |
gnomAD chr6:32552123 rs17879702 |
- | 0.031714 | - | - | |
| 16_HIS | TYR |
8.3kJPN chr6:32489919 rs199680107 |
- | 0.0061 | - | - | |
| 16_HIS | GLN |
8.3kJPN chr6:32552121 rs17879981 |
- | 0.0187 | - | - | |
| 16_HIS | TYR |
8.3kJPN chr6:32552123 rs17879702 |
- | 0.1645 | - | - | |
| 18_PHE | LEU |
gnomAD chr6:32552117 rs114435757 |
- | 0.00153931 | - | - | |
| 18_PHE | LEU |
8.3kJPN chr6:32489913 rs201628145 |
- | 0.0676 | - | - | |
| 18_PHE | TYR |
8.3kJPN chr6:32552116 - |
- | 0.0001 | - | - | |
| 18_PHE | LEU |
8.3kJPN chr6:32552117 rs114435757 |
- | 0.2573 | - | - | |
| 22_GLU | GLN |
8.3kJPN chr6:32552105 - |
- | 0.0001 | - | - | |
| 23_ARG | LEU |
8.3kJPN chr6:32552101 - |
- | 0.0001 | - | - | |
| 24_VAL | GLU |
8.3kJPN chr6:32552098 rs1335931724 |
- | 0.0008 | - | - | |
| 25_ARG | GLN |
gnomAD chr6:32552095 rs17885382 |
- | 0.000191237 | - | - | |
| 25_ARG | GLN |
8.3kJPN chr6:32489891 rs112906420 |
- | 0.0012 | - | - | |
| 25_ARG | TRP |
8.3kJPN chr6:32489892 rs184278615 |
- | 0.0838 | - | - | |
| 25_ARG | GLN |
8.3kJPN chr6:32552095 rs17885382 |
- | 0.0014 | - | - | |
| 25_ARG | TRP |
8.3kJPN chr6:32552096 rs188617679 |
- | 0.2577 | - | - | |
| 26_PHE | LEU |
gnomAD chr6:32489887 rs202197820 |
- | 0.000648374 | - | - | |
| 26_PHE | LEU |
gnomAD chr6:32489887 rs202197820 |
- | 0.00119301 | - | - | |
| 26_PHE | TYR |
gnomAD chr6:32489888 rs147440497 |
- | 0.0457758 | - | - | |
| 26_PHE | LEU |
gnomAD chr6:32552091 rs1059572 |
- | 0.0106895 | - | - | |
| 26_PHE | TYR |
gnomAD chr6:32552092 rs1059569 |
- | 0.131883 | - | - | |
| 26_PHE | ILE |
gnomAD chr6:32552093 rs201128876 |
- | 0.00153433 | - | - | |
| 26_PHE | TYR |
8.3kJPN chr6:32489888 rs147440497 |
- | 0.3205 | - | - | |
| 26_PHE | ILE |
8.3kJPN chr6:32489889 rs201469165 |
- | 0.0856 | - | - | |
| 26_PHE | LEU |
8.3kJPN chr6:32552091 rs1059572 |
- | - | - | - | |
| 26_PHE | TYR |
8.3kJPN chr6:32552092 rs1059569 |
- | 0.3616 | - | - | |
| 26_PHE | ILE |
8.3kJPN chr6:32552093 rs201128876 |
- | 0.2045 | - | - | |
| 28_HIS | GLN |
gnomAD chr6:32489881 rs202185589 |
- | 0.000211982 | - | - | |
| 28_HIS | GLN |
gnomAD chr6:32489881 rs202185589 |
- | 0.00071544 | - | - | |
| 28_HIS | ASP |
gnomAD chr6:32489883 rs142793258 |
- | 0.0371285 | - | - | |
| 28_ASP | GLU |
gnomAD chr6:32552085 rs1059575 |
- | 0.0502833 | - | - | |
| 28_ASP | GLU |
gnomAD chr6:32552085 rs1059575 |
- | 0.0718385 | - | - | |
| 28_ASP | VAL |
gnomAD chr6:32552086 rs200532329 |
- | 0.00159896 | - | - | |
| 28_ASP | TYR |
gnomAD chr6:32552087 rs17878947 |
- | 0.0505099 | - | - | |
| 28_ASP | ASN |
gnomAD chr6:32552087 rs17878947 |
- | 0.00163787 | - | - | |
| 28_HIS | GLN |
8.3kJPN chr6:32489881 rs202185589 |
- | - | - | - | |
| 28_HIS | LEU |
8.3kJPN chr6:32489882 rs200298678 |
- | 0.0902 | - | - | |
| 28_HIS | TYR |
8.3kJPN chr6:32489883 rs142793258 |
- | - | - | - | |
| 28_ASP | GLU |
8.3kJPN chr6:32552085 rs1059575 |
- | - | - | - | |
| 28_ASP | VAL |
8.3kJPN chr6:32552086 rs200532329 |
- | 0.2569 | - | - | |
| 28_ASP | TYR |
8.3kJPN chr6:32552087 rs17878947 |
- | - | - | - | |
| 30_ASP | GLY |
gnomAD chr6:32489876 rs41546317 |
- | 0.273379 | - | - | |
| 30_ASP | TYR |
gnomAD chr6:32489877 rs138849995 |
- | 0.0248491 | - | - | |
| 30_ASP | HIS |
gnomAD chr6:32489877 rs138849995 |
- | 0.000192949 | - | - | |
| 30_TYR | PHE |
gnomAD chr6:32552080 rs3175105 |
- | 0.000143563 | - | - | |
| 30_TYR | CYS |
gnomAD chr6:32552080 rs3175105 |
- | 0.0114161 | - | - | |
| 30_TYR | HIS |
gnomAD chr6:32552081 rs11554462 |
- | 0.0164392 | - | - | |
| 30_ASP | VAL |
8.3kJPN chr6:32489876 rs41546317 |
- | - | - | - | |
| 30_ASP | TYR |
8.3kJPN chr6:32489877 rs138849995 |
- | - | - | - | |
| 30_TYR | PHE |
8.3kJPN chr6:32552080 rs3175105 |
- | - | - | - | |
| 30_TYR | HIS |
8.3kJPN chr6:32552081 rs11554462 |
- | 0.1285 | - | - | |
| 31_ILE | PHE |
gnomAD chr6:32489874 rs140781802 |
- | 0.0253416 | - | - | |
| 31_ILE | VAL |
gnomAD chr6:32489874 rs140781802 |
- | 0.000165271 | - | - | |
| 31_PHE | ILE |
gnomAD chr6:32552078 rs17882300 |
- | 0.0234445 | - | - | |
| 31_ILE | PHE |
8.3kJPN chr6:32489874 rs140781802 |
- | - | - | - | |
| 31_PHE | ILE |
8.3kJPN chr6:32552078 rs17882300 |
- | - | - | - | |
| 32_TYR | HIS |
gnomAD chr6:32489871 rs137863146 |
- | 0.0159466 | - | - | |
| 32_TYR | HIS |
gnomAD chr6:32552075 rs1064664 |
- | 0.256396 | - | - | |
| 32_TYR | HIS |
8.3kJPN chr6:32489871 rs137863146 |
- | 0.0664 | - | - | |
| 32_TYR | HIS |
8.3kJPN chr6:32552075 rs1064664 |
- | 0.2465 | - | - | |
| 33_ASN | HIS |
gnomAD chr6:32489868 rs1059576 |
- | 0.000671158 | - | - | |
| 33_ASN | HIS |
gnomAD chr6:32552072 rs17879995 |
- | 0.115207 | - | - | |
| 33_ASN | HIS |
8.3kJPN chr6:32489868 rs1059576 |
- | 0.1914 | - | - | |
| 33_ASN | THR |
8.3kJPN chr6:32552071 - |
- | 0.0001 | - | - | |
| 33_ASN | HIS |
8.3kJPN chr6:32552072 rs17879995 |
- | 0.1318 | - | - | |
| 37_ASP | VAL |
gnomAD chr6:32489855 rs200042906 |
- | 0.00121985 | - | - | |
| 37_ASP | ALA |
gnomAD chr6:32489855 rs200042906 |
- | 0.00592497 | - | - | |
| 37_ASP | TYR |
gnomAD chr6:32489856 rs707956 |
- | 0.086144 | - | - | |
| 37_ASP | ASN |
gnomAD chr6:32489856 rs707956 |
- | 0.262709 | - | - | |
| 37_SER | PHE |
gnomAD chr6:32552059 rs707957 |
- | 0.0795254 | - | - | |
| 37_SER | TYR |
gnomAD chr6:32552059 rs707957 |
- | 0.568406 | - | - | |
| 37_SER | THR |
gnomAD chr6:32552060 rs16822820 |
- | 0.194034 | - | - | |
| 37_ASP | GLU |
8.3kJPN chr6:32489854 rs770407170 |
- | 0.0007 | - | - | |
| 37_ASP | VAL |
8.3kJPN chr6:32489855 rs200042906 |
- | - | - | - | |
| 37_ASP | TYR |
8.3kJPN chr6:32489856 rs707956 |
- | - | - | - | |
| 37_SER | PHE |
8.3kJPN chr6:32552059 rs707957 |
- | - | - | - | |
| 37_SER | THR |
8.3kJPN chr6:32552060 rs16822820 |
- | 0.0921 | - | - | |
| 38_LEU | SER |
gnomAD chr6:32489852 rs192498095 |
- | 0.010882 | - | - | |
| 38_LEU | VAL |
gnomAD chr6:32489853 rs1059580 |
- | 0.379601 | - | - | |
| 38_VAL | ALA |
gnomAD chr6:32552056 rs17878951 |
- | 0.00251768 | - | - | |
| 38_VAL | LEU |
gnomAD chr6:32552057 rs17878614 |
- | 0.00358455 | - | - | |
| 38_LEU | SER |
8.3kJPN chr6:32489852 rs192498095 |
- | 0.1272 | - | - | |
| 38_VAL | ALA |
8.3kJPN chr6:32552056 rs17878951 |
- | 0.3105 | - | - | |
| 38_VAL | LEU |
8.3kJPN chr6:32552057 rs17878614 |
- | 0.057 | - | - | |
| 39_ARG | GLY |
8.3kJPN chr6:32552054 rs754953589 |
- | 0.0001 | - | - | |
| 40_PHE | TYR |
gnomAD chr6:32489846 rs150479833 |
- | 0.00188581 | - | - | |
| 40_PHE | TYR |
8.3kJPN chr6:32489846 rs150479833 |
- | 0.0976 | - | - | |
| 40_PHE | TYR |
8.3kJPN chr6:32552050 rs17882455 |
- | 0.255 | - | - | |
| 40_PHE | VAL |
8.3kJPN chr6:32552051 - |
- | 0.0001 | - | - | |
| 41_ASP | ASN |
gnomAD chr6:32489844 rs140580884 |
- | 0.000470975 | - | - | |
| 41_ASP | ASN |
8.3kJPN chr6:32489844 rs140580884 |
- | 0.0939 | - | - | |
| 41_ASP | ASN |
8.3kJPN chr6:32552048 rs56158521 |
- | 0.3257 | - | - | |
| 42_SER | GLY |
8.3kJPN chr6:32489841 - |
- | 0.0001 | - | - | |
| 44_VAL | LEU |
gnomAD chr6:32489835 rs118111025 |
- | 0.0275528 | - | - | |
| 44_VAL | LEU |
gnomAD chr6:32552039 rs150747106 |
- | 0.00175038 | - | - | |
| 44_VAL | MET |
gnomAD chr6:32552039 rs150747106 |
- | 0.147503 | - | - | |
| 44_VAL | MET |
8.3kJPN chr6:32489835 rs118111025 |
- | - | - | - | |
| 44_VAL | MET |
8.3kJPN chr6:32552039 rs150747106 |
- | - | - | - | |
| 45_GLY | ARG |
8.3kJPN chr6:32552036 rs17885437 |
- | 0.0001 | - | - | |
| 47_TYR | PHE |
gnomAD chr6:32489825 rs148834340 |
- | 0.0977658 | - | - | |
| 47_PHE | TYR |
gnomAD chr6:32552029 rs17884945 |
- | 0.314464 | - | - | |
| 47_TYR | PHE |
8.3kJPN chr6:32489825 rs148834340 |
- | 0.0443 | - | - | |
| 47_PHE | TYR |
8.3kJPN chr6:32552029 rs17884945 |
- | 0.5244 | - | - | |
| 48_ARG | GLN |
gnomAD chr6:32489822 rs115417906 |
- | 0.0289843 | - | - | |
| 48_ARG | GLN |
8.3kJPN chr6:32489822 rs115417906 |
- | 0.0773 | - | - | |
| 48_ARG | GLN |
8.3kJPN chr6:32552026 rs17886436 |
- | 0.2556 | - | - | |
| 50_VAL | ALA |
gnomAD chr6:32552020 rs17885908 |
- | 0.00264425 | - | - | |
| 51_THR | ARG |
gnomAD chr6:32489813 rs79606458 |
- | 0.0176113 | - | - | |
| 51_THR | ARG |
gnomAD chr6:32552017 rs1059582 |
- | 0.000126062 | - | - | |
| 51_THR | ARG |
8.3kJPN chr6:32489813 rs79606458 |
- | 0.0196 | - | - | |
| 51_THR | ARG |
8.3kJPN chr6:32552017 rs1059582 |
- | 0.0609 | - | - | |
| 52_GLU | VAL |
ClinVar chr6:32552014 - |
Pathogenic | - | - | Pulmonary artery atresia [Human Phenotype Ontology:HP:0004935,MedGen:C0265908] | |
| 57_ASP | VAL |
gnomAD chr6:32489795 rs144532965 |
- | 0.0113368 | - | - | |
| 57_ASP | GLY |
gnomAD chr6:32489795 rs144532965 |
- | 0.0395773 | - | - | |
| 57_ASP | ALA |
gnomAD chr6:32489795 rs144532965 |
- | 0.000118267 | - | - | |
| 57_ASP | ASN |
gnomAD chr6:32489796 rs145586726 |
- | 0.0350737 | - | - | |
| 57_ASP | VAL |
gnomAD chr6:32551999 rs17885129 |
- | 0.00835667 | - | - | |
| 57_ASP | GLY |
gnomAD chr6:32551999 rs17885129 |
- | 0.00650247 | - | - | |
| 57_ASP | ALA |
gnomAD chr6:32551999 rs17885129 |
- | 0.00835028 | - | - | |
| 57_ASP | ASN |
gnomAD chr6:32552000 rs17880292 |
- | 0.00566168 | - | - | |
| 57_ASP | VAL |
8.3kJPN chr6:32489795 rs144532965 |
- | - | - | - | |
| 57_ASP | ASN |
8.3kJPN chr6:32489796 rs145586726 |
- | 0.1956 | - | - | |
| 57_ASP | VAL |
8.3kJPN chr6:32551999 rs17885129 |
- | - | - | - | |
| 57_ASP | ASN |
8.3kJPN chr6:32552000 rs17880292 |
- | 0.123 | - | - | |
| 58_ALA | ASP |
gnomAD chr6:32489792 rs41562816 |
- | 0.113137 | - | - | |
| 58_ALA | ASP |
gnomAD chr6:32551996 rs1059584 |
- | 0.0098369 | - | - | |
| 58_ALA | ASP |
8.3kJPN chr6:32489792 rs41562816 |
- | 0.0246 | - | - | |
| 58_ALA | ASP |
8.3kJPN chr6:32551996 rs1059584 |
- | 0.0026 | - | - | |
| 60_TYR | SER |
gnomAD chr6:32489786 rs41541218 |
- | 0.012153 | - | - | |
| 60_TYR | SER |
gnomAD chr6:32551990 rs1059586 |
- | 0.00564727 | - | - | |
| 60_TYR | HIS |
gnomAD chr6:32551991 rs17882583 |
- | 0.007458 | - | - | |
| 60_TYR | SER |
8.3kJPN chr6:32489786 rs41541218 |
- | 0.1506 | - | - | |
| 60_TYR | HIS |
8.3kJPN chr6:32489787 rs746070999 |
- | - | - | - | |
| 60_TYR | SER |
8.3kJPN chr6:32551990 rs1059586 |
- | 0.1099 | - | - | |
| 60_TYR | HIS |
8.3kJPN chr6:32551991 rs17882583 |
- | 0.0417 | - | - | |
| 61_TRP | ARG |
8.3kJPN chr6:32551988 - |
- | 0.0001 | - | - | |
| 67_PHE | LEU |
gnomAD chr6:32489766 rs696318 |
- | 0.0565996 | - | - | |
| 67_PHE | ILE |
gnomAD chr6:32489766 rs696318 |
- | 0.0461624 | - | - | |
| 67_ILE | PHE |
gnomAD chr6:32551970 rs17886918 |
- | 0.00867543 | - | - | |
| 67_ILE | LEU |
gnomAD chr6:32551970 rs17886918 |
- | 0.201872 | - | - | |
| 67_PHE | ILE |
8.3kJPN chr6:32489766 rs696318 |
- | - | - | - | |
| 67_ILE | PHE |
8.3kJPN chr6:32551970 rs17886918 |
- | - | - | - | |
| 69_GLU | ALA |
8.3kJPN chr6:32489759 rs764618537 |
- | 0.0004 | - | - | |
| 69_GLU | TER |
8.3kJPN chr6:32551964 - |
- | 0.0001 | - | - | |
| 70_ASP | GLU |
gnomAD chr6:32489755 rs41559913 |
- | 0.00041613 | - | - | |
| 70_ASP | GLU |
8.3kJPN chr6:32489755 rs41559913 |
- | 0.0013 | - | - | |
| 71_ARG | THR |
gnomAD chr6:32489753 rs41544215 |
- | 0.00199454 | - | - | |
| 71_ARG | LYS |
gnomAD chr6:32489753 rs41544215 |
- | 0.0548634 | - | - | |
| 71_ARG | GLY |
gnomAD chr6:32489754 rs41551116 |
- | 0.0377136 | - | - | |
| 71_ALA | GLY |
gnomAD chr6:32551957 rs9269942 |
- | 0.191881 | - | - | |
| 71_ALA | GLU |
gnomAD chr6:32551957 rs9269942 |
- | 0.0233567 | - | - | |
| 71_ALA | THR |
gnomAD chr6:32551958 rs1064592 |
- | 0.352483 | - | - | |
| 71_ARG | SER |
8.3kJPN chr6:32489752 rs143737208 |
- | 0.0003 | - | - | |
| 71_ARG | LYS |
8.3kJPN chr6:32489753 rs41544215 |
- | 0.0291 | - | - | |
| 71_ARG | GLY |
8.3kJPN chr6:32489754 rs41551116 |
- | 0.0588 | - | - | |
| 71_ALA | GLU |
8.3kJPN chr6:32551957 rs9269942 |
- | - | - | - | |
| 71_ALA | THR |
8.3kJPN chr6:32551958 rs1064592 |
- | 0.3453 | - | - | |
| 72_ARG | GLY |
8.3kJPN chr6:32489751 rs149410716 |
- | 0.0003 | - | - | |
| 72_ARG | TRP |
8.3kJPN chr6:32551955 rs17885222 |
- | 0.0016 | - | - | |
| 74_ALA | VAL |
gnomAD chr6:32489744 rs1059598 |
- | 0.0855483 | - | - | |
| 74_ALA | GLU |
gnomAD chr6:32489744 rs1059598 |
- | 0.00996973 | - | - | |
| 74_ALA | PRO |
gnomAD chr6:32489745 rs41548618 |
- | 0.0829852 | - | - | |
| 74_ALA | VAL |
gnomAD chr6:32551948 rs17886882 |
- | 0.000898266 | - | - | |
| 74_ALA | GLU |
gnomAD chr6:32551948 rs17886882 |
- | 0.118064 | - | - | |
| 74_ALA | PRO |
gnomAD chr6:32551949 rs16822805 |
- | 0.000608804 | - | - | |
| 74_ALA | THR |
gnomAD chr6:32551949 rs16822805 |
- | 0.00761005 | - | - | |
| 74_ALA | VAL |
8.3kJPN chr6:32489744 rs1059598 |
- | - | - | - | |
| 74_ALA | THR |
8.3kJPN chr6:32489745 rs41548618 |
- | - | - | - | |
| 74_ALA | VAL |
8.3kJPN chr6:32551948 rs17886882 |
- | - | - | - | |
| 74_ALA | THR |
8.3kJPN chr6:32551949 rs16822805 |
- | - | - | - | |
| 76_ASP | GLY |
8.3kJPN chr6:32489738 rs776845219 |
- | 0.0005 | - | - | |
| 76_ASP | GLY |
8.3kJPN chr6:32551942 rs767943289 |
- | 0.0107 | - | - | |
| 77_THR | ASN |
gnomAD chr6:32489735 rs115817940 |
- | 0.00716526 | - | - | |
| 77_THR | ASN |
gnomAD chr6:32551939 rs9269941 |
- | 0.0159839 | - | - | |
| 77_THR | ASN |
8.3kJPN chr6:32489735 rs115817940 |
- | 0.1034 | - | - | |
| 77_THR | ASN |
8.3kJPN chr6:32551939 rs9269941 |
- | 0.1856 | - | - | |
| 78_TYR | PHE |
gnomAD chr6:32489732 rs1064677 |
- | 0.00221315 | - | - | |
| 78_TYR | ASP |
gnomAD chr6:32489733 rs1064595 |
- | 0.00223623 | - | - | |
| 78_TYR | PHE |
8.3kJPN chr6:32489732 rs1064677 |
- | 0.0872 | - | - | |
| 78_TYR | ASP |
8.3kJPN chr6:32489733 rs1064595 |
- | 0.0873 | - | - | |
| 78_TYR | PHE |
8.3kJPN chr6:32551936 rs17879620 |
- | - | - | - | |
| 78_TYR | ASP |
8.3kJPN chr6:32551937 rs17884043 |
- | 0.0002 | - | - | |
| 80_ARG | LYS |
8.3kJPN chr6:32489726 - |
- | 0.0001 | - | - | |
| 81_HIS | TYR |
gnomAD chr6:32489724 rs142908883 |
- | 0.00047137 | - | - | |
| 81_HIS | TYR |
gnomAD chr6:32551928 rs29029549 |
- | 0.0450279 | - | - | |
| 81_HIS | TYR |
8.3kJPN chr6:32489724 rs142908883 |
- | 0.0154 | - | - | |
| 81_HIS | ARG |
8.3kJPN chr6:32551927 - |
- | 0.0001 | - | - | |
| 81_HIS | TYR |
8.3kJPN chr6:32551928 rs29029549 |
- | - | - | - | |
| 85_VAL | ALA |
gnomAD chr6:32551915 rs17424145 |
- | 0.0203139 | - | - | |
| 85_VAL | ALA |
8.3kJPN chr6:32489711 rs1136778 |
- | 0.0108 | - | - | |
| 85_VAL | ALA |
8.3kJPN chr6:32551915 rs17424145 |
- | 0.0444 | - | - | |
| 86_VAL | GLY |
gnomAD chr6:32551912 rs17885482 |
- | 0.0854845 | - | - | |
| 86_GLY | VAL |
8.3kJPN chr6:32489708 rs41556512 |
- | 0.0228 | - | - | |
| 86_VAL | GLY |
8.3kJPN chr6:32551912 rs17885482 |
- | 0.2507 | - | - | |
| 89_PHE | LEU |
8.3kJPN chr6:32489700 - |
- | 0.0001 | - | - | |
| 96_GLU | ASP |
gnomAD chr6:32487424 rs141474277 |
- | 0.00907456 | - | - | |
| 96_GLN | HIS |
gnomAD chr6:32549611 rs1071752 |
- | 0.501137 | - | - | |
| 96_GLU | ASP |
8.3kJPN chr6:32487424 rs141474277 |
- | - | - | - | |
| 96_GLU | TER |
8.3kJPN chr6:32487426 rs1071751 |
- | - | - | - | |
| 96_GLN | HIS |
8.3kJPN chr6:32549611 rs1071752 |
- | - | - | - | |
| 96_GLN | TER |
8.3kJPN chr6:32549613 rs17882084 |
- | - | - | - | |
| 98_LYS | GLU |
gnomAD chr6:32487420 rs138786370 |
- | 0.0369287 | - | - | |
| 98_LYS | GLN |
gnomAD chr6:32487420 rs138786370 |
- | 0.014728 | - | - | |
| 98_LYS | GLU |
gnomAD chr6:32549607 rs17405219 |
- | 0.00318656 | - | - | |
| 98_LYS | GLN |
gnomAD chr6:32549607 rs17405219 |
- | 0.0903753 | - | - | |
| 98_LYS | GLN |
8.3kJPN chr6:32487420 rs138786370 |
- | - | - | - | |
| 98_LYS | GLN |
8.3kJPN chr6:32549607 rs17405219 |
- | - | - | - | |
| 102_TYR | CYS |
8.3kJPN chr6:32549594 rs1195941088 |
- | 0.0001 | - | - | |
| 104_ALA | VAL |
gnomAD chr6:32487401 rs758743151 |
- | 0.000169048 | - | - | |
| 104_ALA | SER |
gnomAD chr6:32487402 rs114131132 |
- | 0.144843 | - | - | |
| 104_ALA | VAL |
8.3kJPN chr6:32487401 rs758743151 |
- | 0.014 | - | - | |
| 104_ALA | SER |
8.3kJPN chr6:32487402 rs114131132 |
- | 0.0271 | - | - | |
| 104_SER | LEU |
8.3kJPN chr6:32549588 rs201929247 |
- | 0.2775 | - | - | |
| 104_SER | ALA |
8.3kJPN chr6:32549589 rs2308760 |
- | 0.3891 | - | - | |
| 105_ARG | LYS |
gnomAD chr6:32487398 rs115198947 |
- | 0.378218 | - | - | |
| 105_ARG | LYS |
8.3kJPN chr6:32487398 rs115198947 |
- | 0.5764 | - | - | |
| 120_ASN | SER |
gnomAD chr6:32487353 rs114293611 |
- | 0.126415 | - | - | |
| 120_ASN | SER |
8.3kJPN chr6:32487353 rs114293611 |
- | 0.3118 | - | - | |
| 120_SER | ASN |
8.3kJPN chr6:32549540 rs1059351 |
- | 0.2977 | - | - | |
| 123_TYR | CYS |
8.3kJPN chr6:32487344 rs201863832 |
- | 0.1009 | - | - | |
| 123_TYR | CYS |
8.3kJPN chr6:32549531 rs112796209 |
- | 0.2949 | - | - | |
| 125_GLY | ALA |
gnomAD chr6:32549525 rs16822698 |
- | 0.113657 | - | - | |
| 125_GLY | ALA |
8.3kJPN chr6:32487338 rs113395425 |
- | 0.1018 | - | - | |
| 125_GLY | ALA |
8.3kJPN chr6:32549525 rs16822698 |
- | 0.2962 | - | - | |
| 127_ILE | VAL |
gnomAD chr6:32549520 rs202047044 |
- | 0.00606299 | - | - | |
| 127_ILE | VAL |
8.3kJPN chr6:32487333 rs199986849 |
- | 0.1025 | - | - | |
| 127_ILE | VAL |
8.3kJPN chr6:32549520 rs202047044 |
- | 0.2104 | - | - | |
| 133_LEU | ARG |
gnomAD chr6:32549501 rs707954 |
- | 0.655748 | - | - | |
| 133_LEU | GLN |
gnomAD chr6:32549501 rs707954 |
- | 0.198249 | - | - | |
| 133_ARG | GLN |
8.3kJPN chr6:32487314 rs201882312 |
- | 0.1743 | - | - | |
| 133_LEU | GLN |
8.3kJPN chr6:32549501 rs707954 |
- | - | - | - | |
| 135_SER | GLY |
gnomAD chr6:32487309 rs1059633 |
- | 0.773043 | - | - | |
| 135_GLY | SER |
gnomAD chr6:32549496 rs757966595 |
- | 0.00286634 | - | - | |
| 135_SER | GLY |
8.3kJPN chr6:32487309 rs1059633 |
- | 0.7151 | - | - | |
| 138_GLU | LYS |
gnomAD chr6:32487300 rs141514736 |
- | 0.000149782 | - | - | |
| 140_ALA | THR |
gnomAD chr6:32487294 rs75709987 |
- | 0.28998 | - | - | |
| 140_ALA | THR |
8.3kJPN chr6:32487294 rs75709987 |
- | 0.2776 | - | - | |
| 140_ALA | THR |
8.3kJPN chr6:32549481 rs78916069 |
- | 0.3391 | - | - | |
| 141_GLY | VAL |
8.3kJPN chr6:32549477 - |
- | 0.0001 | - | - | |
| 142_MET | VAL |
gnomAD chr6:32549475 rs701829 |
- | 0.863959 | - | - | |
| 142_MET | VAL |
8.3kJPN chr6:32549475 rs701829 |
- | 0.8131 | - | - | |
| 149_GLN | HIS |
gnomAD chr6:32487265 rs139485758 |
- | 0.00403901 | - | - | |
| 149_GLN | HIS |
gnomAD chr6:32487265 rs139485758 |
- | 0.0667887 | - | - | |
| 149_GLN | HIS |
8.3kJPN chr6:32487265 rs139485758 |
- | - | - | - | |
| 149_GLN | HIS |
8.3kJPN chr6:32549452 rs77637983 |
- | - | - | - | |
| 153_TRP | TER |
8.3kJPN chr6:32549441 - |
- | 0.0001 | - | - | |
| 157_THR | ILE |
gnomAD chr6:32487242 rs41559420 |
- | 0.0298228 | - | - | |
| 157_THR | ILE |
8.3kJPN chr6:32487242 rs41559420 |
- | 0.0111 | - | - | |
| 159_VAL | MET |
gnomAD chr6:32549424 rs112116022 |
- | 0.0380135 | - | - | |
| 159_VAL | MET |
8.3kJPN chr6:32487237 rs192264100 |
- | 0.1504 | - | - | |
| 159_VAL | MET |
8.3kJPN chr6:32549424 rs112116022 |
- | 0.2358 | - | - | |
| 166_ARG | GLN |
gnomAD chr6:32487215 rs148933006 |
- | 0.0158838 | - | - | |
| 166_ARG | GLN |
gnomAD chr6:32549402 rs3205588 |
- | 0.0738165 | - | - | |
| 166_ARG | GLN |
8.3kJPN chr6:32487215 rs148933006 |
- | 0.0508 | - | - | |
| 166_ARG | GLN |
8.3kJPN chr6:32549402 rs3205588 |
- | 0.1624 | - | - | |
| 168_GLY | ALA |
8.3kJPN chr6:32487209 rs189435670 |
- | 0.2772 | - | - | |
| 168_GLY | ALA |
8.3kJPN chr6:32549396 rs2308775 |
- | 0.1814 | - | - | |
| 172_THR | SER |
8.3kJPN chr6:32549385 - |
- | 0.0001 | - | - | |
| 175_VAL | LEU |
8.3kJPN chr6:32487189 rs201575183 |
- | 0.2812 | - | - | |
| 175_VAL | LEU |
8.3kJPN chr6:32549376 rs36044702 |
- | 0.1709 | - | - | |
| 176_GLU | LYS |
8.3kJPN chr6:32487186 rs772100213 |
- | 0.0002 | - | - | |
| 180_VAL | LEU |
gnomAD chr6:32487174 rs112872773 |
- | 0.186502 | - | - | |
| 180_VAL | MET |
gnomAD chr6:32487174 rs112872773 |
- | 0.0185597 | - | - | |
| 180_VAL | LEU |
gnomAD chr6:32549361 rs111739605 |
- | 0.000737479 | - | - | |
| 180_VAL | MET |
gnomAD chr6:32549361 rs111739605 |
- | 0.130972 | - | - | |
| 180_VAL | MET |
8.3kJPN chr6:32487174 rs112872773 |
- | - | - | - | |
| 180_VAL | MET |
8.3kJPN chr6:32549361 rs111739605 |
- | - | - | - | |
| 181_THR | MET |
gnomAD chr6:32487170 rs1136633 |
- | 0.170325 | - | - | |
| 181_THR | ILE |
gnomAD chr6:32549357 rs200809587 |
- | 0.147837 | - | - | |
| 181_THR | MET |
8.3kJPN chr6:32487170 rs1136633 |
- | 0.3647 | - | - | |
| 181_THR | ILE |
8.3kJPN chr6:32549357 rs200809587 |
- | 0.3785 | - | - | |
| 182_SER | ARG |
8.3kJPN chr6:32487166 - |
- | 0.0002 | - | - | |
| 182_SER | ARG |
8.3kJPN chr6:32549353 - |
- | 0.0002 | - | - | |
| 183_PRO | ALA |
gnomAD chr6:32487165 rs142204283 |
- | 0.0631835 | - | - | |
| 183_PRO | ALA |
gnomAD chr6:32549352 rs1136846 |
- | 0.00757603 | - | - | |
| 183_PRO | LEU |
8.3kJPN chr6:32487164 rs111541713 |
- | 0.2886 | - | - | |
| 183_PRO | ALA |
8.3kJPN chr6:32487165 rs142204283 |
- | 0.0255 | - | - | |
| 183_PRO | LEU |
8.3kJPN chr6:32549351 rs17885501 |
- | 0.1569 | - | - | |
| 183_PRO | ALA |
8.3kJPN chr6:32549352 rs1136846 |
- | 0.0469 | - | - | |
| 185_THR | ILE |
8.3kJPN chr6:32549345 rs752658977 |
- | 0.0002 | - | - | |
| 187_GLU | GLN |
gnomAD chr6:32549340 rs33936261 |
- | 0.128889 | - | - | |
| 187_GLU | GLN |
8.3kJPN chr6:32487153 rs112024745 |
- | 0.0853 | - | - | |
| 187_GLU | GLN |
8.3kJPN chr6:32549340 rs33936261 |
- | 0.3103 | - | - | |
| 189_ARG | SER |
8.3kJPN chr6:32548632 rs1136881 |
- | 0.2322 | - | - | |
| 189_ARG | GLY |
8.3kJPN chr6:32549334 - |
- | 0.0001 | - | - |