PDB ID 1AOI     CHAIN B
Protein name HISTONE H4
Uniprot Accession P62799
The number of similar proteins 457
The number of binding states 30
The number of binding partners 26

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   KRHRKVLRDN   IQGITKPAIR   RLARRGGVKR   ISGLIYEETR   GVLKVFLENV   50
51   IRDAVTYTEH   AKRKTVTAMD   VVYALKRQGR   TLYGFGG     100

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
20_LYS GLN 8.3kJPN
chr6:26247145
rs1354706295
- 0.0001 - -
23_ARG TER 8.3kJPN
chr6:26204942
rs372764747
- 0.0002 - -
23_ARG CYS 8.3kJPN
chr6:27841219
-
- 0.0001 - -
26_ILE SER gnomAD
chr6:26189225
rs750884941
- 0.000111404 - -
31_LYS THR ClinVar
chr6:26204967
-
Pathogenic - - Tessadori-Van Haaften neurodevelopmental syndrome 3 [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950]
31_LYS GLN 8.3kJPN
chr6:26027387
-
- 0.0001 - -
32_PRO LEU ClinVar
chr6:26204970
-
Likely pathogenic - - not provided|Inborn genetic diseases [MedGen:C3661900|MeSH:D030342,MedGen:C0950123]
32_PRO LEU ClinVar
chr6:26104273
-
Pathogenic - - not provided [MedGen:CN517202]
32_PRO ARG ClinVar
chr6:26104273
-
Likely pathogenic - - not provided [MedGen:CN517202]
32_PRO ARG ClinVar
chr6:26204970
-
Pathogenic - - Tessadori-Van Haaften neurodevelopmental syndrome 3 [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950]
33_ALA VAL 8.3kJPN
chr6:26022007
rs776166186
- 0.0001 - -
33_ALA THR 8.3kJPN
chr6:26027381
-
- 0.0001 - -
34_ILE LEU 8.3kJPN
chr6:26189202
rs1011647555
- 0.0001 - -
34_ILE THR 8.3kJPN
chr6:26204976
rs768482468
- 0.0001 - -
35_ARG TRP ClinVar
chr6:26204978
-
Pathogenic - - Tessadori-Van Haaften neurodevelopmental syndrome 3 [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950]
35_ARG TRP ClinVar
chr6:27792008
-
Likely pathogenic - - Tessadori-van Haaften neurodevelopmental syndrome 2 [MONDO:MONDO:0030730,MedGen:C5676923,OMIM:619759]
36_ARG PRO ClinVar
chr6:26204982
-
Likely pathogenic - - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
37_LEU PHE 8.3kJPN
chr6:27107199
-
- 0.0001 - -
40_ARG LEU ClinVar
chr6:27107209
-
Pathogenic - - Tessadori-Van Haaften neurodevelopmental syndrome 4 [MONDO:MONDO:0031000,MedGen:C5677016,OMIM:619951]
45_ARG SER ClinVar
chr6:26104311
-
Likely pathogenic - - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
45_ARG TER 8.3kJPN
chr6:26027345
rs767025164
- 0.0001 - -
47_SER TER 8.3kJPN
chr6:26240796
-
- 0.0001 - -
50_ILE VAL gnomAD
chr6:26247055
rs370289402
- 0.000115357 - -
50_ILE LEU 8.3kJPN
chr6:26205023
rs756223901
- 0.0001 - -
50_ILE VAL 8.3kJPN
chr6:26240804
rs1367180593
- 0.0001 - -
51_TYR PHE 8.3kJPN
chr6:27799151
-
- 0.0001 - -
52_GLU ALA 8.3kJPN
chr6:26027323
-
- 0.0001 - -
52_GLU GLY 8.3kJPN
chr6:26240811
rs773141004
- 0.0001 - -
54_THR ILE gnomAD
chr6:26247042
rs573072581
- 0.000167058 - -
54_THR SER 8.3kJPN
chr6:26240817
rs1046492095
- 0.0001 - -
55_ARG HIS 8.3kJPN
chr6:26027314
rs1195708639
- 0.0002 - -
55_ARG GLN 8.3kJPN
chr12:14923852
rs534031465
- 0.0001 - -
55_ARG TRP 8.3kJPN
chr12:14923853
rs762150713
- 0.0001 - -
57_VAL GLY 8.3kJPN
chr6:26027308
rs1031808362
- 0.0001 - -
57_VAL LEU 8.3kJPN
chr6:26189133
-
- 0.0001 - -
57_VAL ILE 8.3kJPN
chr6:26205044
-
- 0.0001 - -
57_VAL LEU 8.3kJPN
chr6:26247034
rs200377159
- 0.0082 - -
57_VAL MET 8.3kJPN
chr6:27107259
rs1013949364
- 0.0001 - -
60_VAL ALA 8.3kJPN
chr6:26027299
rs780045847
- 0.0001 - -
61_PHE LEU 8.3kJPN
chr6:27799120
rs746877857
- 0.0002 - -
64_ASN ASP 8.3kJPN
chr6:26240846
-
- 0.0001 - -
65_VAL ILE 8.3kJPN
chr6:26104371
-
- 0.0001 - -
66_ILE VAL gnomAD
chr6:26027282
rs777598662
- 0.000131219 - -
67_ARG TRP 8.3kJPN
chr6:27107289
rs1291040170
- 0.0005 - -
67_ARG HIS 8.3kJPN
chr12:14923816
-
- 0.0001 - -
68_ASP GLY 8.3kJPN
chr6:26027275
-
- 0.0001 - -
70_VAL MET 8.3kJPN
chr6:26246995
rs140916075
- 0.0001 - -
73_THR PRO 8.3kJPN
chr12:14923799
rs1171400276
- 0.0002 - -
74_GLU ASP 8.3kJPN
chr6:27107312
-
- 0.0001 - -
75_HIS ARG ClinVar
chr6:27107314
-
Pathogenic - - Tessadori-Van Haaften neurodevelopmental syndrome 4 [MONDO:MONDO:0031000,MedGen:C5677016,OMIM:619951]
77_LYS GLN ClinVar
chr6:26205104
-
Likely pathogenic - - H4C5-related condition [-]
77_LYS ASN 8.3kJPN
chr6:26240887
-
- 0.0001 - -
78_ARG PRO gnomAD
chr6:26022142
rs143300286
- 0.000374421 - -
78_ARG CYS gnomAD
chr6:26027246
rs777473620
- 0.000151114 - -
78_ARG PRO gnomAD
chr6:26240889
rs747684677
- 0.000132062 - -
80_THR ALA 8.3kJPN
chr12:14923778
rs760388462
- 0.0001 - -
81_VAL ALA gnomAD
chr6:26022151
rs199857326
- 0.000227104 - -
82_THR ILE gnomAD
chr6:26022154
rs776076104
- 0.000299053 - -
82_THR ILE 8.3kJPN
chr6:26027233
rs150504596
- 0.0001 - -
82_THR ILE 8.3kJPN
chr6:26189057
rs144742137
- 0.005 - -
82_THR SER 8.3kJPN
chr6:26246958
-
- 0.0001 - -
82_THR ILE 8.3kJPN
chr6:27799058
rs372460457
- 0.0001 - -
83_ALA VAL gnomAD
chr6:26022157
rs147105535
- 0.00173549 - -
83_ALA SER 8.3kJPN
chr6:26240903
-
- 0.0001 - -
84_MET ILE 8.3kJPN
chr6:26027226
-
- 0.0001 - -
84_MET ILE 8.3kJPN
chr6:27792157
-
- - - -
85_ASP GLY gnomAD
chr6:27841032
rs201833445
- 0.000127245 - -
85_ASP GLU 8.3kJPN
chr6:26022164
-
- 0.0001 - -
85_ASP ASN 8.3kJPN
chr6:26240909
-
- 0.0004 - -
86_VAL LEU 8.3kJPN
chr6:26027222
-
- 0.0001 - -
87_VAL ILE 8.3kJPN
chr6:26104437
-
- 0.0001 - -
88_TYR HIS 8.3kJPN
chr12:14923754
-
- 0.0001 - -
89_ALA SER gnomAD
chr6:26104443
rs144469714
- 0.000318441 - -
89_ALA THR 8.3kJPN
chr6:26104443
rs144469714
- 0.0001 - -
89_ALA VAL 8.3kJPN
chr6:26104444
-
- 0.0001 - -
89_ALA THR 8.3kJPN
chr12:14923751
rs776707867
- 0.0001 - -
90_LEU PRO 8.3kJPN
chr6:26205144
-
- 0.0001 - -
91_LYS GLN ClinVar
chr6:26104449
rs1763200003
Pathogenic - - HIST1H4C-associated disorder [-]
91_LYS GLU ClinVar
chr6:27792176
rs2113887393
Pathogenic - - Tessadori-van Haaften neurodevelopmental syndrome 2 [MONDO:MONDO:0030730,MedGen:C5676923,OMIM:619759]
91_LYS GLN ClinVar
chr6:27792176
rs2113887393
Pathogenic - - Tessadori-van Haaften neurodevelopmental syndrome 1 [MONDO:MONDO:0030729,MedGen:C5676922,OMIM:619758]
91_LYS ARG ClinVar
chr6:26104450
rs2113784630
Likely pathogenic - - Tessadori-van Haaften neurodevelopmental syndrome 1 [MONDO:MONDO:0030729,MedGen:C5676922,OMIM:619758]
91_LYS GLU ClinVar
chr6:26104449
rs1763200003
Pathogenic - - Tessadori-van Haaften neurodevelopmental syndrome 1 [MONDO:MONDO:0030729,MedGen:C5676922,OMIM:619758]
92_ARG CYS 8.3kJPN
chr6:26104452
-
- 0.0001 - -
95_ARG GLY 8.3kJPN
chr6:27792188
-
- 0.0001 - -
98_TYR HIS ClinVar
chr6:26205167
-
Likely pathogenic - - Tessadori-Van Haaften neurodevelopmental syndrome 3|Inborn genetic diseases [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950|MeSH:D030342,MedGen:C0950123]
99_GLY VAL 8.3kJPN
chr6:26027182
-
- 0.0001 - -
99_GLY ASP 8.3kJPN
chr6:27840990
-
- 0.0001 - -
102_GLY SER gnomAD
chr6:27840982
rs45526033
- 0.00601938 - -
102_GLY ASP 8.3kJPN
chr6:26240961
rs151068394
- 0.0075 - -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.