| PDB ID | 8JHL
|
CHAIN | A |
|---|---|---|---|
| Protein name | GTPase KRas, N-terminally processed | ||
| Uniprot Accession | P01116 | ||
| The number of similar proteins | 634 | ||
| The number of binding states | 33 | ||
| The number of binding partners | 25 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 8JHL (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
P04049
|
| 3 |
Q9BPZ7
|
| 4 |
P01116
|
| 5 |
P62937
|
| 6 |
5UFQ
|
| 7 |
P40337
|
| 8 |
P21359
|
| 9 |
8BE3
|
| 10 |
7NY8
|
| 11 |
O43924
|
| 12 |
5MLB
|
| 13 |
8F0M
|
| 14 |
Q07889
|
| 15 |
Q9BPZ7
|
| 16 |
Q9NZL6
|
| 17 |
Q9BPZ7
|
| 18 |
Q9QZQ1
|
| 19 |
Q8TDF6
|
| 20 |
P48736
|
| 21 |
P28829
|
| 22 |
Q14449
|
| 23 |
2C5L
|
| 24 |
P01116
P01116
|
| 25 |
P10398
P02647
|
| 26 |
7YV1
7YV1
|
| 27 |
8BE4
Q07889
|
| 28 |
7MDP
7MDP
|
| 29 |
5WPM
5WPM
|
| 30 |
2UZI
2UZI
|
| 31 |
8BE5
8BE5
Q07889
|
| 32 |
P01116-2
O15211
O15211
|
| 33 |
P01116-2
P01116-2
P01116-2
P01116-2
|
Downdload
Molecule viewer
|
Only interaction residues |
|
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|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 5_LYS | ASN |
VAR_064849
rs104894361 |
LP/P | - | 0.992 | Gastric cancer (GASC) [MIM:613659] | |
| 5_LYS | GLU |
VAR_065144
rs193929331 |
LP/P | - | 0.9889 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 13_GLY | ASP |
VAR_016029
rs112445441 |
LP/P | - | 0.998 | Gastric cancer (GASC) [MIM:613659] | |
| 13_GLY | ARG |
VAR_065145
rs121913535 |
LB/B | - | 0.9972 | - | |
| 14_VAL | ILE |
VAR_026109
rs104894365 |
LP/P | - | 0.8548 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 19_LEU | PHE |
VAR_083261
rs121913538 |
LP/P | - | 0.9811 | Oculoectodermal syndrome (OES) [MIM:600268] | |
| 22_GLN | GLU |
VAR_064850
rs121913236 |
LP/P | - | 0.8995 | Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278] | |
| 22_GLN | ARG |
VAR_064851
rs727503110 |
LP/P | - | 0.9015 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 34_PRO | ARG |
VAR_026110
rs104894366 |
LP/P | - | 0.9972 | Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278] | |
| 34_PRO | LEU |
VAR_064852
rs104894366 |
LP/P | - | 0.9976 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 34_PRO | GLN |
VAR_064853
- |
LP/P | - | 0.9993 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 36_ILE | MET |
VAR_064854
rs727503109 |
LP/P | - | 0.9755 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 58_THR | ILE |
VAR_026111
rs104894364 |
LP/P | - | 0.9994 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 59_ALA | THR |
VAR_016030
rs121913528 |
LP/P | - | 0.9964 | Gastric cancer (GASC) [MIM:613659] | |
| 60_GLY | ARG |
VAR_026112
rs104894359 |
LP/P | - | 0.9998 | Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278] | |
| 60_GLY | SER |
VAR_065146
rs104894359 |
LP/P | - | 0.9985 | Noonan syndrome 3 (NS3) [MIM:609942] | |
| 61_GLN | HIS |
VAR_006841
rs17851045 |
US | - | 0.9977 | Lung carcinoma | |
| 61_GLN | ARG |
VAR_036306
rs121913240 |
US | - | 0.9866 | A colorectal cancer sample | |
| 71_TYR | HIS |
VAR_069784
rs387907205 |
LP/P | - | 0.9986 | Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278] | |
| 117_LYS | ASN |
VAR_036307
rs770248150 |
US | - | 0.9996 | Colorectal cancer samples | |
| 146_ALA | THR |
VAR_036308
rs121913527 |
LP/P | - | 0.9895 | Oculoectodermal syndrome (OES) [MIM:600268] | |
| 146_ALA | VAL |
VAR_083262
rs1057519725 |
LP/P | - | 0.993 | Oculoectodermal syndrome (OES) [MIM:600268] | |
| 147_LYS | GLU |
VAR_069785
rs387907206 |
LP/P | - | 0.9892 | Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278] |