PDB ID 8JHL     CHAIN A
Protein name GTPase KRas, N-terminally processed
Uniprot Accession P01116
The number of similar proteins 634
The number of binding states 33
The number of binding partners 25

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
8JHL (CHAIN: A)
1 Monomeric state
2 P04049  
3 Q9BPZ7  
4 P01116  
5 P62937  
6 5UFQ  
7 P40337  
8 P21359  
9 8BE3  
10 7NY8  
11 O43924  
12 5MLB  
13 8F0M  
14 Q07889  
15 Q9BPZ7  
16 Q9NZL6  
17 Q9BPZ7  
18 Q9QZQ1  
19 Q8TDF6  
20 P48736  
21 P28829  
22 Q14449  
23 2C5L  
24 P01116   P01116  
25 P10398   P02647  
26 7YV1   7YV1  
27 8BE4   Q07889  
28 7MDP   7MDP  
29 5WPM   5WPM  
30 2UZI   2UZI  
31 8BE5   8BE5   Q07889  
32 P01116-2   O15211   O15211  
33 P01116-2   P01116-2   P01116-2   P01116-2  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MTEYKLVVVG   ADGVGKSALT   IQLIQNHFVD   EYDPTIEDSY   RKQVVIDGET   50
51   CLLDILDTAG   QEEYSAMRDQ   YMRTGEGFLC   VFAINNTKSF   EDIHHYREQI   100
101   KRVKDSEDVP   MVLVGNKCDL   PSRTVDTKQA   QDLARSYGIP   FIETSAKTRQ   150
151   RVEDAFYTLV   REIRQYRLK         200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
5_LYS ASN VAR_064849 rs104894361
LP/P - Gastric cancer (GASC) [MIM:613659]
5_LYS GLU VAR_065144 rs193929331
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
13_GLY ASP VAR_016029 rs112445441
LP/P - Gastric cancer (GASC) [MIM:613659]
13_GLY ARG VAR_065145 rs121913535
LB/B - -
14_VAL ILE VAR_026109 rs104894365
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
19_LEU PHE VAR_083261 rs121913538
LP/P - Oculoectodermal syndrome (OES) [MIM:600268]
22_GLN GLU VAR_064850 rs121913236
LP/P - Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
22_GLN ARG VAR_064851 rs727503110
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
34_PRO ARG VAR_026110 rs104894366
LP/P - Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
34_PRO LEU VAR_064852 rs104894366
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
34_PRO GLN VAR_064853 -
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
36_ILE MET VAR_064854 rs727503109
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
58_THR ILE VAR_026111 rs104894364
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
59_ALA THR VAR_016030 rs121913528
LP/P - Gastric cancer (GASC) [MIM:613659]
60_GLY ARG VAR_026112 rs104894359
LP/P - Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
60_GLY SER VAR_065146 rs104894359
LP/P - Noonan syndrome 3 (NS3) [MIM:609942]
61_GLN HIS VAR_006841 rs17851045
US - Lung carcinoma
61_GLN ARG VAR_036306 rs121913240
US - A colorectal cancer sample
71_TYR HIS VAR_069784 rs387907205
LP/P - Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
117_LYS ASN VAR_036307 rs770248150
US - Colorectal cancer samples
146_ALA THR VAR_036308 rs121913527
LP/P - Oculoectodermal syndrome (OES) [MIM:600268]
146_ALA VAL VAR_083262 rs1057519725
LP/P - Oculoectodermal syndrome (OES) [MIM:600268]
147_LYS GLU VAR_069785 rs387907206
LP/P - Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.