PDB ID 8JHL     CHAIN A
Protein name GTPase KRas, N-terminally processed
Uniprot Accession P01116
The number of similar proteins 794
The number of binding states 40
The number of binding partners 29

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MTEYKLVVVG   ADGVGKSALT   IQLIQNHFVD   EYDPTIEDSY   RKQVVIDGET   50
51   CLLDILDTAG   QEEYSAMRDQ   YMRTGEGFLC   VFAINNTKSF   EDIHHYREQI   100
101   KRVKDSEDVP   MVLVGNKCDL   PSRTVDTKQA   QDLARSYGIP   FIETSAKTRQ   150
151   RVEDAFYTLV   REIRQYRLK         200

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
5_LYS ASN VAR_064849
rs104894361
LP/P - 0.992 Gastric cancer (GASC) [MIM:613659]
5_LYS GLU VAR_065144
rs193929331
LP/P - 0.9889 Noonan syndrome 3 (NS3) [MIM:609942]
13_GLY ASP VAR_016029
rs112445441
LP/P - 0.998 Gastric cancer (GASC) [MIM:613659]
13_GLY ARG VAR_065145
rs121913535
LB/B - 0.9972 -
14_VAL ILE VAR_026109
rs104894365
LP/P - 0.8548 Noonan syndrome 3 (NS3) [MIM:609942]
19_LEU PHE VAR_083261
rs121913538
LP/P - 0.9811 Oculoectodermal syndrome (OES) [MIM:600268]
22_GLN GLU VAR_064850
rs121913236
LP/P - 0.8995 Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
22_GLN ARG VAR_064851
rs727503110
LP/P - 0.9015 Noonan syndrome 3 (NS3) [MIM:609942]
34_PRO ARG VAR_026110
rs104894366
LP/P - 0.9972 Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
34_PRO LEU VAR_064852
rs104894366
LP/P - 0.9976 Noonan syndrome 3 (NS3) [MIM:609942]
34_PRO GLN VAR_064853
rs104894366
LP/P - 0.9993 Noonan syndrome 3 (NS3) [MIM:609942]
36_ILE MET VAR_064854
rs727503109
LP/P - 0.9755 Noonan syndrome 3 (NS3) [MIM:609942]
58_THR ILE VAR_026111
rs104894364
LP/P - 0.9994 Noonan syndrome 3 (NS3) [MIM:609942]
59_ALA THR VAR_016030
rs121913528
LP/P - 0.9964 Gastric cancer (GASC) [MIM:613659]
60_GLY ARG VAR_026112
rs104894359
LP/P - 0.9998 Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
60_GLY SER VAR_065146
rs104894359
LP/P - 0.9985 Noonan syndrome 3 (NS3) [MIM:609942]
61_GLN HIS VAR_006841
rs17851045
US - 0.9977 Lung carcinoma
61_GLN ARG VAR_036306
rs121913240
US - 0.9866 A colorectal cancer sample
71_TYR HIS VAR_069784
rs387907205
LP/P - 0.9986 Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
117_LYS ASN VAR_036307
rs770248150
US - 0.9996 Colorectal cancer samples
146_ALA THR VAR_036308
rs121913527
LP/P - 0.9895 Oculoectodermal syndrome (OES) [MIM:600268]
146_ALA VAL VAR_083262
rs1057519725
LP/P - 0.993 Oculoectodermal syndrome (OES) [MIM:600268]
147_LYS GLU VAR_069785
rs387907206
LP/P - 0.9892 Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.