| PDB ID | 7MZW
|
CHAIN | A |
|---|---|---|---|
| Protein name | ALK tyrosine kinase receptor | ||
| Uniprot Accession | Q9UM73 | ||
| The number of similar proteins | 8 | ||
| The number of binding states | 4 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 7MZW (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q9UM73
|
| 3 |
7NX3
7NX3
|
| 4 |
Q9UM73
Q6UX46
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 680_THR | ILE |
VAR_041482
rs35228363 |
LB/B | - | 0.1984 | - | |
| 685_PHE | VAL |
gnomAD chr2:29474122 rs761545025 |
- | 0.00020653 | 0.7613 | - | |
| 704_ALA | THR |
VAR_041483
rs34829159 |
LB/B | - | 0.0963 | - | |
| 709_ASN | LYS |
gnomAD chr2:29474048 rs376175333 |
- | 0.00105992 | 0.2759 | - | |
| 717_GLU | LYS |
gnomAD chr2:29474026 rs147858673 |
- | 0.000231192 | 0.0663 | - | |
| 737_SER | LEU |
gnomAD chr2:29462691 rs368581969 |
- | 0.000119797 | 0.2808 | - | |
| 859_GLU | ASP |
gnomAD chr2:29455225 rs61754865 |
- | 0.00026244 | 0.7618 | - | |
| 868_LEU | GLN |
VAR_061288
rs55941323 |
LB/B | - | 0.0667 | - | |
| 877_ALA | SER |
VAR_041484
rs746442213 |
US | - | 0.1891 | An ovarian serous carcinoma sample | |
| 1012_THR | MET |
VAR_041485
rs35073634 |
LB/B | - | 0.0636 | - | |
| 1012_THR | MET |
gnomAD chr2:29449820 rs35073634 |
- | 0.000699957 | 0.0636 | - |