PDB ID 7MZW     CHAIN A
Protein name ALK tyrosine kinase receptor
Uniprot Accession Q9UM73
The number of similar proteins 8
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
7MZW (CHAIN: A)
1 Monomeric state
2 Q9UM73  
3 7NX3   7NX3  
4 Q9UM73   Q6UX46  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   QTPIFDPTVH   WLFTTCGASG   PHGPTQAQCN   NAYQNSNLSV   EVGSEGPLKG   50
51   IQIWKVPATD   TYSISGYGAA   GGKGGKNTMM   RSHGVSVLGI   FNLEKDDMLY   100
101   ILVGQQGEDA   CPSTNQLIQK   VCIGENNVIE   EEIRVNRSVH   EWAGGGGGGG   150
151   GATYVFKMKD   GVPVPLIIAA   GGGGRAYGAK   TDTFHPERLE   NNSSVLGLNG   200
201   NSGAAGGGGG   WNDNTSLLWA   GKSLQEGATG   GHSCPQAMKK   WGWETRGGFG   250
251   GGGGGCSSGG   GGGGYIGGNA   ASNNDPEMDG   EDGVSFISPL   GILYTPALKV   300
301   MEGHGEVNIK   HYLNCSHCEV   DECHMDPESH   KVICFCDHGT   VLAEDGVSCI   350
351   VSP           400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
680_THR ILE VAR_041482 rs35228363
LB/B - -
685_PHE VAL gnomAD
chr2:29474122 		rs761545025
- 0.00020653 -
704_ALA THR VAR_041483 rs34829159
LB/B - -
709_ASN LYS gnomAD
chr2:29474048 		rs376175333
- 0.00105992 -
717_GLU LYS gnomAD
chr2:29474026 		rs147858673
- 0.000231192 -
737_SER LEU gnomAD
chr2:29462691 		rs368581969
- 0.000119797 -
859_GLU ASP gnomAD
chr2:29455225 		rs61754865
- 0.00026244 -
868_LEU GLN VAR_061288 rs55941323
LB/B - -
877_ALA SER VAR_041484 rs746442213
US - An ovarian serous carcinoma sample
1012_THR MET VAR_041485 rs35073634
LB/B - -
1012_THR MET gnomAD
chr2:29449820 		rs35073634
- 0.000699957 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.