PDB ID 6XAR     CHAIN A
Protein name E3 ubiquitin-protein ligase CBL
Uniprot Accession P22681
The number of similar proteins 22
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
6XAR (CHAIN: A)
1 Monomeric state
2 P68036  
3 6O02  
4 P22681  
5 P22681   P22681  
6 P22681   P0CG48   P0CG48  

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Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GSLIGLMKDA   FQPHHHHHHH   LSPHPPGTVD   KKMVEKCWKL   MDKVVRLCQN   50
51   PKLALKNSPP   YILDLLPDTY   QHLRTILSRY   EGKMETLGEN   EYFRVFMENL   100
101   MKKTKQTISL   FKEGKERMYE   ENSQPRRNLT   KLSLIFSHML   AELKGIFPSG   150
151   LFQGDTFRIT   KADAAEFWRK   AFGEKTIVPW   KSFRQALHEV   HPISSGLEAM   200
201   ALKSTIDLTC   NDYISVFEFD   IFTRLFQPWS   SLLRNWNSLA   VTHPGYMAFL   250
251   TYDEVKARLQ   KFIHKPGSYI   FRLSCTRLGQ   WAIGYVTADG   NILQTIPHNK   300
301   PLFQALIDGF   REGFYLFPDG   RNQNPDLTGL   CEPTP     350

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
76_GLN LEU gnomAD
chr3:105572480
rs116692800
- 0.000352485 - -
256_ARG GLN gnomAD
chr3:105464863
rs560042700
- 0.000127403 0.5784 -
287_LYS ARG VAR_071040
-
US - 0.2128 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.