| PDB ID | 5MN2
|
CHAIN | A |
|---|---|---|---|
| Protein name | Low affinity immunoglobulin gamma Fc region receptor III-A | ||
| Uniprot Accession | P08637 | ||
| The number of similar proteins | 22 | ||
| The number of binding states | 6 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 5MN2 (CHAIN: A) | |
| 1 |
5MN2
|
| 2 | Monomeric state |
| 3 |
9PRU
9PRU
|
| 4 |
P0DOX5
P0DOX5
|
| 5 |
P01857
P01857
|
| 6 |
P01857
P01857
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 8_ALA | SER |
8.3kJPN chr1:161518454 - |
- | 0.0001 | 0.1846 | - | |
| 12_LEU | MET |
8.3kJPN chr1:161518442 - |
- | 0.0001 | 0.2281 | - | |
| 18_SER | ARG |
gnomAD chr1:161599779 rs200688856 |
- | 0.0114824 | - | - | |
| 18_SER | ARG |
8.3kJPN chr1:161599779 rs200688856 |
- | 0.1079 | - | - | |
| 19_VAL | MET |
gnomAD chr1:161599778 rs375357751 |
- | 0.000332842 | 0.3189 | - | |
| 21_GLU | LYS |
gnomAD chr1:161518415 rs565792189 |
- | 0.000195104 | 0.1902 | - | |
| 21_GLU | ASP |
8.3kJPN chr1:161599770 - |
- | 0.0005 | 0.5802 | - | |
| 22_LYS | GLN |
8.3kJPN chr1:161599769 - |
- | 0.0001 | 0.1517 | - | |
| 28_LYS | ASN |
gnomAD chr1:161518392 rs747338915 |
- | 0.00010352 | 0.4007 | - | |
| 28_LYS | ASN |
8.3kJPN chr1:161518392 rs747338915 |
- | 0.0001 | 0.4007 | - | |
| 32_ALA | SER |
gnomAD chr1:161599739 rs532065559 |
- | 0.000134245 | 0.0759 | - | |
| 33_TYR | SER |
8.3kJPN chr1:161518378 rs781008829 |
- | 0.0002 | 0.0847 | - | |
| 36_GLU | LYS |
8.3kJPN chr1:161518370 rs1417155615 |
- | 0.0001 | 0.0718 | - | |
| 36_GLU | LYS |
8.3kJPN chr1:161599727 rs772985521 |
- | 0.0071 | 0.0718 | - | |
| 41_GLN | ARG |
8.3kJPN chr1:161599711 rs754782443 |
- | 0.0007 | 0.0687 | - | |
| 45_ASN | SER |
8.3kJPN chr1:161599699 rs750461683 |
- | 0.0001 | 0.1509 | - | |
| 47_SER | ASN |
gnomAD chr1:161518336 rs77144485 |
- | 0.096397 | 0.0783 | - | |
| 47_ASN | SER |
gnomAD chr1:161599693 rs448740 |
- | 0.618663 | - | - | |
| 47_SER | ARG |
8.3kJPN chr1:161518335 rs747670473 |
- | 0.0001 | 0.1451 | - | |
| 47_SER | ASN |
8.3kJPN chr1:161518336 rs77144485 |
- | 0.4221 | 0.0783 | - | |
| 47_ASN | SER |
8.3kJPN chr1:161599693 rs448740 |
- | 0.5922 | - | - | |
| 48_LEU | ARG |
VAR_008799
rs10127939 |
LB/B | - | 0.0741 | - | |
| 48_LEU | HIS |
VAR_008800
rs10127939 |
LP/P | - | 0.1205 | Immunodeficiency 20 (IMD20) [MIM:615707] | |
| 48_LEU | ARG |
gnomAD chr1:161518333 rs10127939 |
- | 0.0433121 | 0.0741 | - | |
| 48_LEU | HIS |
gnomAD chr1:161518333 rs10127939 |
- | 0.0554121 | 0.1205 | - | |
| 48_LEU | HIS |
8.3kJPN chr1:161518333 rs10127939 |
- | 0.0001 | 0.1205 | - | |
| 54_SER | LEU |
gnomAD chr1:161518315 rs143870625 |
- | 0.000867945 | 0.1405 | - | |
| 54_SER | LEU |
8.3kJPN chr1:161518315 rs143870625 |
- | 0.0004 | 0.1405 | - | |
| 60_ALA | ASP |
gnomAD chr1:161518297 rs52820103 |
- | 0.000806761 | 0.1047 | - | |
| 60_ALA | PRO |
gnomAD chr1:161518298 rs771557708 |
- | 0.000215013 | 0.3732 | - | |
| 60_ALA | ASP |
gnomAD chr1:161599654 rs5030738 |
- | 0.0378302 | 0.1047 | - | |
| 60_ALA | THR |
gnomAD chr1:161599655 rs201152581 |
- | 0.00063324 | 0.0832 | - | |
| 62_THR | ALA |
gnomAD chr1:161518292 rs142322800 |
- | 0.000147307 | 0.0824 | - | |
| 63_VAL | ILE |
8.3kJPN chr1:161518289 - |
- | 0.0001 | 0.0902 | - | |
| 64_ASN | ASP |
gnomAD chr1:161599643 rs147574249 |
- | 0.101268 | - | - | |
| 64_ASP | ASN |
8.3kJPN chr1:161518286 rs428888 |
- | 0.065 | 0.0646 | - | |
| 64_ASN | ASP |
8.3kJPN chr1:161599643 rs147574249 |
- | 0.2495 | - | - | |
| 65_ASP | GLU |
gnomAD chr1:161599638 rs371151798 |
- | 0.000101188 | 0.5536 | - | |
| 84_LEU | PRO |
8.3kJPN chr1:161518225 rs1317230218 |
- | 0.0004 | 0.9524 | - | |
| 88_ILE | VAL |
gnomAD chr1:161599571 rs2290834 |
- | 0.266628 | 0.0747 | - | |
| 88_ILE | VAL |
8.3kJPN chr1:161518214 rs148181339 |
- | 0.4245 | 0.0747 | - | |
| 88_ILE | VAL |
8.3kJPN chr1:161599571 rs2290834 |
- | 0.2675 | 0.0747 | - | |
| 97_ARG | GLN |
gnomAD chr1:161596168 rs200319084 |
- | 0.000385384 | 0.0776 | - | |
| 97_ARG | GLN |
8.3kJPN chr1:161514724 rs1031388823 |
- | 0.0001 | 0.0776 | - | |
| 97_ARG | TRP |
8.3kJPN chr1:161514725 rs778260076 |
- | 0.0002 | 0.1745 | - | |
| 97_ARG | TRP |
8.3kJPN chr1:161596169 rs776782096 |
- | 0.0001 | 0.1745 | - | |
| 105_PRO | ALA |
8.3kJPN chr1:161596145 - |
- | 0.0002 | 0.0906 | - | |
| 111_HIS | PRO |
8.3kJPN chr1:161514682 - |
- | 0.0001 | 0.8983 | - | |
| 119_HIS | GLN |
8.3kJPN chr1:161514657 - |
- | 0.0001 | 0.1478 | - | |
| 129_GLY | ASP |
VAR_058398
rs443082 |
LB/B | - | 0.683 | - | |
| 140_TYR | HIS |
VAR_058399
rs396716 |
LB/B | - | 0.0655 | - | |
| 140_TYR | HIS |
8.3kJPN chr1:161514596 rs396716 |
- | 0.0001 | 0.0655 | - | |
| 140_HIS | TYR |
8.3kJPN chr1:161596040 rs71632958 |
- | 0.0001 | - | - | |
| 147_LYS | ASN |
gnomAD chr1:161596017 rs376472862 |
- | 0.000123766 | 0.1781 | - | |
| 150_GLY | SER |
gnomAD chr1:161514566 rs200049912 |
- | 0.000386165 | 0.5961 | - | |
| 150_GLY | SER |
gnomAD chr1:161596010 rs188904436 |
- | 0.00017571 | 0.5961 | - | |
| 150_GLY | ARG |
8.3kJPN chr1:161596010 - |
- | 0.0001 | 0.9069 | - | |
| 152_TYR | ASP |
8.3kJPN chr1:161596004 - |
- | 0.0001 | 0.9794 | - | |
| 154_CYS | PHE |
gnomAD chr1:161514553 rs749893099 |
- | 0.000115478 | 0.975 | - | |
| 154_CYS | ARG |
8.3kJPN chr1:161514554 - |
- | 0.0001 | 0.9812 | - | |
| 158_PHE | VAL |
VAR_003960
rs396991 |
LB/B | - | 0.0795 | - | |
| 158_PHE | VAL |
gnomAD chr1:161514542 rs396991 |
- | 0.325003 | 0.0795 | - | |
| 158_VAL | PHE |
gnomAD chr1:161595986 rs200215055 |
- | 0.00147764 | - | - | |
| 158_PHE | VAL |
8.3kJPN chr1:161514542 rs396991 |
- | 0.2783 | 0.0795 | - | |
| 158_VAL | PHE |
8.3kJPN chr1:161595986 rs200215055 |
- | 0.0001 | - | - |