PDB ID 5JLZ     CHAIN A
Protein name HLA class II histocompatibility antigen, DR alpha chain
Uniprot Accession P01903
The number of similar proteins 133
The number of binding states 16
The number of binding partners 9

Coloring

Unicolor (beige)

The number of binding partners

Group

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   IKEEHVIIQA   EFYLNPDQSG   EFMFDFDGDE   IFHVDMAKKE   TVWRLEEFGR   50
51   FASFEAQGAL   ANIAVDKANL   EIMTKRSNYT   PITNVPPEVT   VLTNSPVELR   100
101   EPNVLICFID   KFTPPVVNVT   WLRNGKPVTT   GVSETVFLPR   EDHLFRKFHY   150
151   LPFLPSTEDV   YDCRVEHWGL   DEPLLKHWEF   DSSADLVPR     200

Variants

Residue AA Source /
dbSNP
Clinical
Significance
Allele
Frequency
(> 0.0001)
AlphaMissense
pathogenicity
Disease name
5_HIS ARG 8.3kJPN
chr6:32410231
-
- 0.0001 0.6576 -
76_ARG SER gnomAD
chr6:32410443
rs201781094
- 0.000287349 0.7615 -
81_PRO LEU 8.3kJPN
chr6:32410459
rs754838655
- 0.0001 0.2242 -
93_THR ILE 8.3kJPN
chr6:32410986
rs1407197550
- 0.0001 0.2518 -
123_ARG GLN gnomAD
chr6:32411076
rs138462914
- 0.000576168 0.0772 -
160_VAL ILE 8.3kJPN
chr6:32411186
rs200798853
- 0.0001 0.0794 -
168_TRP ARG gnomAD
chr6:32411210
rs199723815
- 0.000150153 0.4727 -
168_TRP ARG 8.3kJPN
chr6:32411210
rs199723815
- 0.0215 0.4727 -
169_GLY SER 8.3kJPN
chr6:32411213
-
- 0.0001 0.4001 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.