PDB ID 5HI3     CHAIN A
Protein name Interleukin-17A
Uniprot Accession Q16552
The number of similar proteins 46
The number of binding states 10
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
5HI3 (CHAIN: A)
1 2VXS   2VXS   2VXS   2VXS  
2 Monomeric state
3 Q16552  
4 8B7W  
5 8DY1  
6 6WIR   6WIR  
7 Q96PD4   Q96F46  
8 Q16552   5HHX   5HHX  
9 Q16552   4QHU   4QHU   4QHU  
10 Q16552   5N7W   5N7W   5N7W   5N7W  

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Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GITIPRNPGC   PNSEDKNFPR   TVMVNLNIHN   RNTNTNPKRS   SDYYNRSTSP   50
51   WNLHRNEDPE   RYPSVIWEAK   CRHLGCINAD   GNVDYHMNSV   PIQQEILVLR   100
101   REPPHCPNSF   RLEKILVSVG   CTCVTPIVHH   VA     150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
36_ASN SER 8.3kJPN
chr6:52052549 		rs746361396
- 0.0001 -
37_PRO LEU 8.3kJPN
chr6:52052552 		-
- 0.0001 -
55_ARG CYS 8.3kJPN
chr6:52053854 		rs777451627
- 0.0001 -
55_ARG HIS 8.3kJPN
chr6:52053855 		rs760902102
- 0.0001 -
58_ASP GLY 8.3kJPN
chr6:52053864 		-
- 0.0001 -
68_GLU LYS gnomAD
chr6:52053893 		rs151317528
- 0.000131537 -
69_ALA SER gnomAD
chr6:52053896 		rs763243057
- 0.000139504 -
69_ALA SER 8.3kJPN
chr6:52053896 		rs763243057
- 0.0012 -
72_ARG CYS gnomAD
chr6:52053905 		rs199987410
- 0.00108791 -
72_ARG HIS gnomAD
chr6:52053906 		rs755641354
- 0.000151464 -
79_ALA PRO 8.3kJPN
chr6:52053926 		rs756965539
- 0.0002 -
83_VAL MET 8.3kJPN
chr6:52053938 		rs745674559
- 0.0001 -
111_ARG GLN gnomAD
chr6:52054023 		rs147810050
- 0.000518036 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.