PDB ID 5FUC     CHAIN A
Protein name INTERLEUKIN-6
Uniprot Accession P05231
The number of similar proteins 13
The number of binding states 7
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
5FUC (CHAIN: A)
1 5FUC   D6R9R8  
2 Monomeric state
3 P05231  
4 A4L9V2  
5 4CNI   4CNI  
6 4ZS7   4ZS7  
7 P08887   P40189  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GSSSERIDKQ   IRYILDGISA   LRKETCNKSN   MCESSKEALA   ENNLNLPKMA   50
51   EKDGCFQSGF   NEETCLVKII   TGLLEFEVYL   EYLQNRFESS   EEQARAVQMS   100
101   TKVLIQFLQK   KAKNLDAITT   PDPTTNASLL   TKLQAQNQWL   QDMTTHLILR   150
151   SFKEFLQSSL   RALRQM         200

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
49_MET THR 8.3kJPN
chr7:22768331
rs775325818
- 0.0001 0.1288 -
130_ALA SER 8.3kJPN
chr7:22771025
-
- 0.0001 0.1097 -
134_ASP VAL VAR_013076
rs2069860
LB/B - 0.1374 -
134_ASP GLU VAR_029266
rs13306435
LB/B - 0.121 -
134_ASP VAL gnomAD
chr7:22771038
rs2069860
- 0.00596655 0.1374 -
134_ASP GLU gnomAD
chr7:22771039
rs13306435
- 0.0286538 0.121 -
134_ASP GLU 8.3kJPN
chr7:22771039
rs13306435
- 0.0315 0.121 -
143_THR ALA 8.3kJPN
chr7:22771064
-
- 0.0001 0.0654 -
154_GLN GLU 8.3kJPN
chr7:22771097
-
- 0.0001 0.1007 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.