PDB ID 5FQD     CHAIN A
Protein name DNA DAMAGE-BINDING PROTEIN 1
Uniprot Accession Q16531
The number of similar proteins 47
The number of binding states 4
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
5FQD (CHAIN: A)
1 Q96SW2  
2 Q9NYV4  
3 Q9BW61   Q66K64  
4 Q9BW61   Q66K64   Q66K64  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MHHHHHHVDE   ENLYFQGGGR   MSYNYVVTAQ   KPTAVNGCVT   GHFTSAEDLN   50
51   LLIAKNTRLE   IYVVTAEGLR   PVKEVGMYGK   IAVMELFRPK   GESKDLLFIL   100
101   TAKYNACILE   YKQSGESIDI   ITRAHGNVQD   RIGRPSETGI   IGIIDPECRM   150
151   IGLRLYDGLF   KVIPLDRDNK   ELKAFNIRLE   ELHVIDVKFL   YGCQAPTICF   200
201   VYQDPQGRHV   KTYEVSLREK   EFNKGPWKQE   NVEAEASMVI   AVPEPFGGAI   250
251   IIGQESITYH   NGDKYLAIAP   PIIKQSTIVC   HNRVDPNGSR   YLLGDMEGRL   300
301   FMLLLEKEEQ   MDGTVTLKDL   RVELLGETSI   AECLTYLDNG   VVFVGSRLGD   350
351   SQLVKLNVDS   NEQGSYVVAM   ETFTNLGPIV   DMCVVDLERQ   GQGQLVTCSG   400
401   AFKEGSLRII   RNGIGGNGNS   GEIQKLHIRT   VPLYESPRKI   CYQEVSQCFG   450
451   VLSSRIEVQD   TSGGTTALRP   SASTQALSSS   VSSSKLFSSS   TAPHETSFGE   500
501   EVEVHNLLII   DQHTFEVLHA   HQFLQNEYAL   SLVSCKLGKD   PNTYFIVGTA   550
551   MVYPEEAEPK   QGRIVVFQYS   DGKLQTVAEK   EVKGAVYSMV   EFNGKLLASI   600
601   NSTVRLYEWT   TEKELRTECN   HYNNIMALYL   KTKGDFILVG   DLMRSVLLLA   650
651   YKPMEGNFEE   IARDFNPNWM   SAVEILDDDN   FLGAENAFNL   FVCQKDSAAT   700
701   TDEERQHLQE   VGLFHLGEFV   NVFCHGSLVM   QNLGETSTPT   QGSVLFGTVN   750
751   GMIGLVTSLS   ESWYNLLLDM   QNRLNKVIKS   VGKIEHSFWR   SFHTERKTEP   800
801   ATGFIDGDLI   ESFLDISRPK   MQEVVANLQY   DDGSGMKREA   TADDLIKVVE   850
851   ELTRIH           900

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
18_CYS GLY 8.3kJPN
chr11:61100389 		-
- 0.0001 -
25_SER LEU gnomAD
chr11:61099151 		rs35597036
- 0.000743592 -
25_SER ALA 8.3kJPN
chr11:61099152 		-
- 0.0001 -
40_GLU ASP 8.3kJPN
chr11:61099105 		-
- 0.0001 -
68_ARG TRP 8.3kJPN
chr11:61099023 		-
- 0.0001 -
102_THR MET 8.3kJPN
chr11:61097452 		rs754320597
- 0.0001 -
114_ARG HIS ClinVar
chr11:61097043 		rs1231861984
Likely pathogenic - Neurodevelopmental delay [Human Phenotype Ontology:HP:0012758,MedGen:C4022738]
157_ILE ASN 8.3kJPN
chr11:61096914 		-
- 0.0001 -
188_ARG GLN VAR_086006 -
LP/P - White-Kernohan syndrome (WHIKERS) [MIM:619426]
188_ARG TRP VAR_086007 -
LP/P - White-Kernohan syndrome (WHIKERS) [MIM:619426]
188_ARG GLN ClinVar
chr11:61094352 		rs2134935097
Pathogenic - White-Kernohan syndrome [MONDO:MONDO:0859169,MedGen:C5543635,OMIM:619426]
213_GLU LYS VAR_086008 -
LP/P - White-Kernohan syndrome (WHIKERS) [MIM:619426]
213_GLU LYS ClinVar
chr11:61094278 		rs2134934938
Likely pathogenic - White-Kernohan syndrome [MONDO:MONDO:0859169,MedGen:C5543635,OMIM:619426]
241_ASN SER 8.3kJPN
chr11:61093123 		rs1169556093
- 0.0001 -
252_ILE VAL 8.3kJPN
chr11:61093091 		rs1200909412
- 0.0002 -
295_VAL ILE 8.3kJPN
chr11:61091489 		rs756108667
- 0.0001 -
314_LEU PHE 8.3kJPN
chr11:61090546 		-
- 0.0001 -
340_SER ILE 8.3kJPN
chr11:61089871 		-
- 0.0001 -
739_ARG HIS 8.3kJPN
chr11:61079317 		rs190054116
- 0.0001 -
790_ASN HIS 8.3kJPN
chr11:61077800 		rs759310673
- 0.0001 -
805_HIS TYR 8.3kJPN
chr11:61077421 		-
- 0.0001 -
859_GLN ARG 8.3kJPN
chr11:61076540 		-
- 0.0001 -
971_ALA GLY 8.3kJPN
chr11:61070548 		-
- 0.0001 -
978_GLN ARG 8.3kJPN
chr11:61070527 		-
- 0.0001 -
1022_THR SER 8.3kJPN
chr11:61070101 		-
- 0.0001 -
1059_ASN SER 8.3kJPN
chr11:61069768 		rs1197372725
- 0.0001 -
1069_GLU LYS 8.3kJPN
chr11:61069739 		-
- 0.0001 -
1071_SER CYS 8.3kJPN
chr11:61069732 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.